GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **951 - 975** of **2090** in total

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Pathway Name	Protein Name	UniProt ID ▲	Gene Symbol	Organism	GlyTouCan ID
Multifunctional anion exchangers	Anion exchange transporter Chloride anion exchanger Pendrin Sodium-coupled monocarboxylate transporter 2 Sodium-independent sulfate anion transporter Solute carrier family 26 member 6 Solute carrier family 26 member 9 Sulfate anion transporter 1 Sulfate transporter	O43511 P40879 P50443 Q1EHB4 Q7LBE3 Q86WA9 Q8TE54 Q9BXS9 Q9H2B4	DRA DTD DTDST PDS SAT1 SLC26A1 SLC26A11 SLC26A2 SLC26A3 SLC26A4 SLC26A6 SLC26A7 SLC26A9 SLC5A12 SMCT2 SUT2	Homo sapiens (human)
Defective SLC26A4 causes Pendred syndrome (PDS)	Pendrin	O43511	PDS SLC26A4	Homo sapiens (human)
FLT3 Signaling	Bcl-2-like protein 11 Cyclin-dependent kinase inhibitor 1B Fms-related tyrosine kinase 3 ligand Forkhead box protein O3 GRB2-associated-binding protein 2 GRB2-related adapter protein 2 GTPase HRas GTPase NRas Growth factor receptor-bound protein 10 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Receptor-type tyrosine-protein kinase FLT3 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	O43521 O43524 O75791 P01111 P01112 P27986 P31749 P31751 P36888 P42336 P46527 P49771 Q06124 Q07889 Q13322 Q9UQC2 Q9Y243	AKT1 AKT2 AKT3 BCL2L11 BIM CD135 CDKN1B FKHRL1 FLK2 FLT3 FLT3LG FOXO3 FOXO3A GAB2 GADS GRAP2 GRB1 GRB10 GRB2L GRBIR GRID HRAS HRAS1 KIAA0207 KIAA0571 KIP1 NRAS PIK3CA PIK3R1 PKB PKBG PTP2C PTPN11 RAC SHPTP2 SOS1 STK1 p27	Homo sapiens (human)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	14-3-3 protein epsilon Amyloid-beta precursor protein Bcl-2-like protein 11 Calpain small subunit 1 Calpain small subunit 2 Calpain-1 catalytic subunit Calpain-2 catalytic subunit Calpastatin Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 Forkhead box protein O3 Golgin subfamily A member 2 Lamin-B1 M-phase inducer phosphatase 1 M-phase inducer phosphatase 2 M-phase inducer phosphatase 3 Peroxiredoxin-1 Peroxiredoxin-2 Superoxide dismutase [Mn], mitochondrial Transcription factor Jun Tumor necrosis factor ligand superfamily member 6	O43521 O43524 P04179 P04632 P05067 P05412 P07384 P17655 P20700 P20810 P30304 P30305 P30307 P32119 P48023 P62258 Q00535 Q06830 Q08379 Q15078 Q96L46	A4 AD1 APP APT1LG1 BCL2L11 BIM CANPL1 CANPL2 CAPN1 CAPN2 CAPN4 CAPNS CAPNS1 CAPNS2 CAST CD95L CDC25A CDC25B CDC25C CDC25HU2 CDK5 CDK5R CDK5R1 CDKN5 FASL FASLG FKHRL1 FOXO3 FOXO3A GOLGA2 JUN LMN2 LMNB LMNB1 NCK5A NKEFB PAGA PAGB PRDX1 PRDX2 PSSALRE SOD2 TDPX1 TDPX2 TNFSF6 YWHAE	Homo sapiens (human)
FOXO-mediated transcription of cell death genes	B-cell lymphoma 6 protein Bcl-2-binding component 3, isoforms 1/2 Bcl-2-like protein 11 CREB-binding protein Cbp/p300-interacting transactivator 2 DNA damage-inducible transcript 3 protein Forkhead box protein O1 Forkhead box protein O3 Forkhead box protein O4 Histone acetyltransferase p300 Nuclear transcription factor Y subunit alpha Nuclear transcription factor Y subunit beta Nuclear transcription factor Y subunit gamma Serine/threonine-protein kinase PINK1, mitochondrial Serine/threonine-protein kinase STK11 Tumor necrosis factor ligand superfamily member 6	O43521 O43524 P23511 P25208 P35638 P41182 P48023 P98177 Q09472 Q12778 Q13952 Q15831 Q92793 Q99967 Q9BXH1 Q9BXM7	AFX AFX1 APT1LG1 BBC3 BCL2L11 BCL5 BCL6 BIM CBP CD95L CHOP CHOP10 CITED2 CREBBP DDIT3 EP300 FASL FASLG FKHR FKHRL1 FOXO1 FOXO1A FOXO3 FOXO3A FOXO4 GADD153 HAP3 LAZ3 LKB1 MLLT7 MRG1 NFYA NFYB NFYC P300 PINK1 PJS PUMA STK11 TNFSF6 ZBTB27 ZNF51	Homo sapiens (human)
RUNX3 regulates BCL2L11 (BIM) transcription	Bcl-2-like protein 11 Forkhead box protein O3 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Runt-related transcription factor 3	O43521 O43524 P84022 Q13485 Q13761	AML2 BCL2L11 BIM CBFA3 DPC4 FKHRL1 FOXO3 FOXO3A MADH3 MADH4 PEBP2A3 RUNX3 SMAD3 SMAD4	Homo sapiens (human)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	Apoptosis regulator Bcl-2 BH3-interacting domain death agonist Bcl-2-binding component 3, isoforms 1/2 Bcl-2-like protein 11 Bcl-2-like protein 1 Bcl-2-modifying factor Bcl2-associated agonist of cell death Phorbol-12-myristate-13-acetate-induced protein 1 Signal transducer and activator of transcription 3	O43521 P10415 P40763 P55957 Q07817 Q13794 Q92934 Q96LC9 Q9BXH1	APRF BAD BBC3 BBC6 BCL2 BCL2L BCL2L1 BCL2L11 BCL2L8 BCLX BID BIM BMF NOXA PMAIP1 PUMA STAT3	Homo sapiens (human)
Activation of BIM and translocation to mitochondria	Bcl-2-like protein 11 Dynein light chain 1, cytoplasmic Mitogen-activated protein kinase 8	O43521 P45983 P63167	BCL2L11 BIM DLC1 DNCL1 DNCLC1 DYNLL1 HDLC1 JNK1 MAPK8 PRKM8 SAPK1 SAPK1C	Homo sapiens (human)
Regulation of FOXO transcriptional activity by acetylation	CREB-binding protein Forkhead box protein O1 Forkhead box protein O3 Forkhead box protein O4 Histone acetyltransferase KAT2B Histone acetyltransferase p300 NAD-dependent protein deacetylase sirtuin-1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial Thioredoxin-interacting protein Thioredoxin	O43524 P10599 P98177 Q09472 Q12778 Q92793 Q92831 Q96EB6 Q9H3M7 Q9NTG7	AFX AFX1 CBP CREBBP EP300 FKHR FKHRL1 FOXO1 FOXO1A FOXO3 FOXO3A FOXO4 KAT2B MLLT7 P300 PCAF SIR2L1 SIR2L3 SIRT1 SIRT3 TRDX TRX TRX1 TXN TXNIP VDUP1	Homo sapiens (human)
Reactions specific to the complex N-glycan synthesis pathway	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 Alpha-(1,6)-fucosyltransferase Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Alpha-mannosidase 2 Alpha-mannosidase 2x Carbohydrate sulfotransferase 10 Carbohydrate sulfotransferase 8 Glycoprotein hormones alpha chain Lutropin subunit beta Tissue alpha-L-fucosidase	O43529 P01215 P01229 P04066 P21217 P49641 Q10469 Q16706 Q9BYC5 Q9H2A9	CGA CHST10 CHST8 FT3B FUCA1 FUT3 FUT8 LE LHB MAN2A1 MAN2A2 MANA2 MANA2X MGAT2	Homo sapiens (human)	G70323CJ G82576YO
RUNX2 regulates bone development	Core-binding factor subunit beta Mothers against decapentaplegic homolog 1 Mothers against decapentaplegic homolog 4 Mothers against decapentaplegic homolog 6 RNA-binding protein 14	O43541 Q13485 Q13951 Q15797 Q96PK6	BSP1 CBFB DPC4 MADH1 MADH4 MADH6 MADR1 RBM14 SIP SMAD1 SMAD4 SMAD6	Homo sapiens (human)
Hormone ligand-binding receptors	Follicle-stimulating hormone receptor Follitropin subunit beta Glycoprotein hormone alpha-2 Glycoprotein hormone beta-5 Glycoprotein hormones alpha chain Gonadotropin-releasing hormone receptor Lutropin subunit beta Lutropin-choriogonadotropic hormone receptor Progonadoliberin-1 Progonadoliberin-2 Putative gonadotropin-releasing hormone II receptor Thyrotropin receptor Thyrotropin subunit beta	O43555 P01148 P01215 P01222 P01225 P01229 P16473 P22888 P23945 P30968 Q86YW7 Q96P88 Q96T91	CGA FSHB FSHR GNRH GNRH1 GNRH2 GNRHR GNRHR2 GPA2 GPB5 GPHA2 GPHB5 GRH GRHR LCGR LGR1 LGR2 LGR3 LHB LHCGR LHRH LHRHR TSHB TSHR ZLUT1 ZSIG51	Homo sapiens (human)
Activated NTRK2 signals through FRS2 and FRS3	BDNF/NT-3 growth factors receptor Brain-derived neurotrophic factor Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 GTPase HRas GTPase NRas Neurotrophin-4 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	O43559 P01111 P01112 P23560 P34130 Q06124 Q07889 Q16620 Q8WU20	BDNF FRS2 FRS3 HRAS HRAS1 NRAS NTF4 NTF5 NTRK2 PTP2C PTPN11 SHPTP2 SOS1 TRKB	Homo sapiens (human)
Reversible hydration of carbon dioxide	Carbonic anhydrase 12 Carbonic anhydrase 13 Carbonic anhydrase 14 Carbonic anhydrase 1 Carbonic anhydrase 2 Carbonic anhydrase 3 Carbonic anhydrase 4 Carbonic anhydrase 5A, mitochondrial Carbonic anhydrase 5B, mitochondrial Carbonic anhydrase 6 Carbonic anhydrase 7 Carbonic anhydrase 9	O43570 P00915 P00918 P07451 P22748 P23280 P35218 P43166 Q16790 Q8N1Q1 Q9ULX7 Q9Y2D0	CA1 CA12 CA13 CA14 CA2 CA3 CA4 CA5 CA5A CA5B CA6 CA7 CA9 G250 MN	Homo sapiens (human)
Spry regulation of FGF signaling	E3 ubiquitin-protein ligase CBL MAP kinase-interacting serine/threonine-protein kinase 1 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Polyubiquitin-B Polyubiquitin-C Protein sprouty homolog 2 Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Tyrosine-protein phosphatase non-receptor type 11 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O43597 P0CG47 P0CG48 P15056 P22681 P27361 P28482 P30153 P62714 P62979 P62987 P67775 Q06124 Q9BUB5	BRAF BRAF1 CBL CBL2 ERK1 ERK2 MAPK1 MAPK3 MKNK1 MNK1 PPP2CA PPP2CB PPP2R1A PRKM1 PRKM2 PRKM3 PTP2C PTPN11 RAFB1 RNF55 RPS27A SHPTP2 SPRY2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Purine catabolism	5'(3')-deoxyribonucleotidase, cytosolic type 5'-nucleotidase 5-hydroxymethyl-dUMP N-hydrolase Cytosolic 5'-nucleotidase 1A Cytosolic 5'-nucleotidase 1B Cytosolic purine 5'-nucleotidase Guanine deaminase Inosine triphosphate pyrophosphatase Purine nucleoside phosphorylase Xanthine dehydrogenase/oxidase	O43598 P00491 P21589 P47989 P49902 Q8TCD5 Q96P26 Q9BXI3 Q9BY32 Q9Y2T3	AIRP C20orf37 C6orf108 DNPH1 DNT1 GDA ITPA KIAA1258 NP NT5 NT5B NT5C NT5C1A NT5C1B NT5C2 NT5CP NT5E NTE PNP PNT5 RCL UMPH2 XDH XDHA	Homo sapiens (human)
Pyroptosis	Apoptosis regulator BAX Bcl-2 homologous antagonist/killer Caspase-1 Caspase-3 Caspase-4 Caspase-5 Cellular tumor antigen p53 Charged multivesicular body protein 2a Charged multivesicular body protein 2b Charged multivesicular body protein 3 Charged multivesicular body protein 4a Charged multivesicular body protein 4b Charged multivesicular body protein 4c Charged multivesicular body protein 6 Charged multivesicular body protein 7 Cytochrome c Gasdermin-D Gasdermin-E Granzyme B High mobility group protein B1 Interferon regulatory factor 1 Interferon regulatory factor 2 Interleukin-1 alpha Interleukin-1 beta Interleukin-18 Neutrophil elastase Tumor protein 63	O43633 O60443 P01583 P01584 P04637 P08246 P09429 P10144 P10914 P14316 P29466 P42574 P49662 P51878 P57764 P99999 Q07812 Q14116 Q16611 Q8WUX9 Q96CF2 Q96FZ7 Q9BY43 Q9H3D4 Q9H444 Q9UQN3 Q9Y3E7	BAK BAK1 BAX BC2 BCL2L4 BCL2L7 C14orf123 C20orf178 CASP1 CASP3 CASP4 CASP5 CDN1 CGI149 CGL1 CHMP2 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 CPP32 CSPB CTLA1 CYC CYCS DFNA5 DFNA5L ELA2 ELANE GRB GSDMD GSDMDC1 GSDME GZMB HMG1 HMGB1 ICERE1 ICH2 ICH3 IGIF IL18 IL1A IL1B IL1BC IL1BCE IL1F1 IL1F2 IL1F4 IRF1 IRF2 KET NEDF P53 P63 P73H P73L SHAX1 SHAX2 SHAX3 TP53 TP63 TP73L VPS20 VPS24	Homo sapiens (human)
Translation of Replicase and Assembly of the Replication Transcription Complex	Beclin-1 Charged multivesicular body protein 2a Charged multivesicular body protein 2b Charged multivesicular body protein 3 Charged multivesicular body protein 4a Charged multivesicular body protein 4b Charged multivesicular body protein 4c Charged multivesicular body protein 6 Charged multivesicular body protein 7 Microtubule-associated proteins 1A/1B light chain 3B ORF8b protein ORF9b protein Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 Replicase polyprotein 1a Replicase polyprotein 1ab UV radiation resistance-associated gene protein	O43633 P0C6U8 P0C6X7 P59636 Q14457 Q80H93 Q8NEB9 Q8WUX9 Q96CF2 Q96FZ7 Q99570 Q9BY43 Q9GZQ8 Q9H444 Q9P2Y5 Q9UQN3 Q9Y3E7	1a 8b 9b BC2 BECN1 C14orf123 C20orf178 CGI149 CHMP2 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 GT197 MAP1ALC3 MAP1LC3B NEDF PIK3C3 PIK3R4 SHAX1 SHAX2 SHAX3 UVRAG VPS15 VPS20 VPS24 VPS34 rep	Homo sapiens (human)
Translation of Replicase and Assembly of the Replication Transcription Complex	Beclin-1 Charged multivesicular body protein 2a Charged multivesicular body protein 2b Charged multivesicular body protein 3 Charged multivesicular body protein 4a Charged multivesicular body protein 4b Charged multivesicular body protein 4c Charged multivesicular body protein 6 Charged multivesicular body protein 7 Microtubule-associated proteins 1A/1B light chain 3B Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 Replicase polyprotein 1a Replicase polyprotein 1ab UV radiation resistance-associated gene protein	O43633 P0DTC1 P0DTD1 Q14457 Q8NEB9 Q8WUX9 Q96CF2 Q96FZ7 Q99570 Q9BY43 Q9GZQ8 Q9H444 Q9P2Y5 Q9UQN3 Q9Y3E7	BC2 BECN1 C14orf123 C20orf178 CGI149 CHMP2 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 GT197 MAP1ALC3 MAP1LC3B NEDF PIK3C3 PIK3R4 SHAX1 SHAX2 SHAX3 UVRAG VPS15 VPS20 VPS24 VPS34 rep	Homo sapiens (human)
Regulation of cortical dendrite branching	Cytoplasmic protein NCK2 Roundabout homolog 1 Roundabout homolog 2 Slit homolog 1 protein	O43639 O75093 Q9HCK4 Q9Y6N7	DUTT1 GRB4 KIAA0813 KIAA1568 MEGF4 NCK2 ROBO1 ROBO2 SLIL1 SLIT1	Homo sapiens (human)
Activation of RAC1	Cytoplasmic protein NCK2 Ras-related C3 botulinum toxin substrate 1 Roundabout homolog 1 SH2/SH3 adapter protein NCK1 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein kinase PAK 4 Serine/threonine-protein kinase PAK 5 Serine/threonine-protein kinase PAK 6 Slit homolog 2 protein Son of sevenless homolog 1 Son of sevenless homolog 2	O43639 O75914 O94813 O96013 P16333 P63000 Q07889 Q07890 Q13153 Q13177 Q9NQU5 Q9P286 Q9Y6N7	DUTT1 GRB4 KIAA1142 KIAA1264 NCK NCK1 NCK2 OPHN3 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PAK7 RAC1 ROBO1 SLIL3 SLIT2 SOS1 SOS2 TC25	Homo sapiens (human)
Tyrosine catabolism	4-hydroxyphenylpyruvate dioxygenase Fumarylacetoacetase Homogentisate 1,2-dioxygenase Maleylacetoacetate isomerase Tyrosine aminotransferase	O43708 P16930 P17735 P32754 Q93099	FAH GSTZ1 HGD HGO HPD MAAI PPD TAT	Homo sapiens (human)
Carnitine metabolism	5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-2 Carnitine O-palmitoyltransferase 1, liver isoform Carnitine O-palmitoyltransferase 1, muscle isoform Carnitine O-palmitoyltransferase 2, mitochondrial Mid1-interacting protein 1 Mitochondrial carnitine/acylcarnitine carrier protein Organic cation/carnitine transporter 2 Peroxisome proliferator-activated receptor delta Retinoic acid receptor RXR-alpha Thyroid hormone-inducible hepatic protein	O43741 O43772 O76082 P19793 P23786 P50416 P54646 Q03181 Q92523 Q92748 Q9NPA3 Q9UGJ0	AMPK AMPK2 CAC CACT CPT1 CPT1A CPT1B CPT2 KIAA1670 MID1IP1 MIG12 NR1C2 NR2B1 OCTN2 PPARB PPARD PRKAA2 PRKAB2 PRKAG2 RXRA SLC22A5 SLC25A20 THRSP	Homo sapiens (human)
Lipophagy	5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 Heat shock cognate 71 kDa protein Perilipin-2 Perilipin-3	O43741 O60664 P11142 P54619 P54646 Q99541 Q9UGI9 Q9UGJ0 Q9Y478	ADFP AMPK AMPK2 AMPKG3 HSC70 HSP73 HSPA10 HSPA8 M6PRBP1 PLIN2 PLIN3 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 TIP47	Homo sapiens (human)
Activation of AMPK downstream of NMDARs	5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 Calcium/calmodulin-dependent protein kinase kinase 2 Calmodulin-1	O43741 P0DP23 P54619 P54646 Q13131 Q96RR4 Q9UGI9 Q9UGJ0 Q9Y478	AMPK AMPK1 AMPK2 AMPKG3 CALM CALM1 CAM CAM1 CAMKK2 CAMKKB KIAA0787 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3	Homo sapiens (human)

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