GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1001 - 1025** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Defective ALG14 causes ALG14-CMS	UDP-N-acetylglucosamine transferase subunit ALG13 UDP-N-acetylglucosamine transferase subunit ALG14	Q96F25 Q9NP73	ALG13 ALG14 CXorf45 GLT28D1	Homo sapiens (human)
FCERI mediated MAPK activation	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Dual specificity mitogen-activated protein kinase kinase 4 Dual specificity mitogen-activated protein kinase kinase 7 GRB2-related adapter protein 2 GTPase HRas GTPase NRas Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 IGHV7-81 protein Immunoglobulin heavy constant epsilon Immunoglobulin heavy variable 1-2 Immunoglobulin heavy variable 1-46 Immunoglobulin heavy variable 1-69 Immunoglobulin heavy variable 2-5 Immunoglobulin heavy variable 2-70 Immunoglobulin heavy variable 3-11 Immunoglobulin heavy variable 3-13 Immunoglobulin heavy variable 3-23 Immunoglobulin heavy variable 3-30 Immunoglobulin heavy variable 3-33 Immunoglobulin heavy variable 3-48 Immunoglobulin heavy variable 3-53 Immunoglobulin heavy variable 3-7 Immunoglobulin heavy variable 3-9 Immunoglobulin heavy variable 4-34 Immunoglobulin heavy variable 4-39 Immunoglobulin heavy variable 4-59 Immunoglobulin kappa constant Immunoglobulin kappa variable 1-12 Immunoglobulin kappa variable 1-16 Immunoglobulin kappa variable 1-17 Immunoglobulin kappa variable 1-33 Immunoglobulin kappa variable 1-39 Immunoglobulin kappa variable 1-5 Immunoglobulin kappa variable 1D-12 Immunoglobulin kappa variable 1D-16 Immunoglobulin kappa variable 1D-33 Immunoglobulin kappa variable 1D-39 Immunoglobulin kappa variable 2-28 Immunoglobulin kappa variable 2-29 Immunoglobulin kappa variable 2-30 Immunoglobulin kappa variable 2D-28 Immunoglobulin kappa variable 2D-30 Immunoglobulin kappa variable 2D-40 Immunoglobulin kappa variable 3-11 Immunoglobulin kappa variable 3-15 Immunoglobulin kappa variable 3-20 Immunoglobulin kappa variable 3D-20 Immunoglobulin kappa variable 4-1 Immunoglobulin kappa variable 5-2 Immunoglobulin lambda constant 1 Immunoglobulin lambda constant 2 Immunoglobulin lambda constant 3 Immunoglobulin lambda constant 6 Immunoglobulin lambda constant 7 Immunoglobulin lambda variable 1-40 Immunoglobulin lambda variable 1-44 Immunoglobulin lambda variable 1-47 Immunoglobulin lambda variable 1-51 Immunoglobulin lambda variable 2-11 Immunoglobulin lambda variable 2-14 Immunoglobulin lambda variable 2-23 Immunoglobulin lambda variable 2-8 Immunoglobulin lambda variable 3-19 Immunoglobulin lambda variable 3-1 Immunoglobulin lambda variable 3-21 Immunoglobulin lambda variable 3-25 Immunoglobulin lambda variable 3-27 Immunoglobulin lambda variable 6-57 Immunoglobulin lambda variable 7-43 Immunolglobulin kappa light chain variable region L22 (Fragment) Lymphocyte cytosolic protein 2 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Mitogen-activated protein kinase kinase kinase 1 Protein c-Fos Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Son of sevenless homolog 1 Transcription factor Jun Tyrosine-protein kinase Lyn Tyrosine-protein kinase SYK UGa8H (Fragment) V1-11 protein (Fragment) V1-13 protein (Fragment) V1-16 protein (Fragment) V1-20 protein (Fragment) V1-3 protein (Fragment) V1-5 protein (Fragment) V1-7 protein (Fragment) V1-9 protein (Fragment) V2-11 protein (Fragment) V2-15 protein (Fragment) V2-17 protein (Fragment) V2-19 protein (Fragment) V2-8 protein (Fragment) V3-2 protein (Fragment) V3-3 protein (Fragment) V3-4 protein (Fragment) V4-1 protein (Fragment) V4-2 protein (Fragment) V4-6 protein (Fragment) V5-1 protein (Fragment) V5-4 protein (Fragment) V5-6 protein (Fragment)	A0A075B6P5 A0A075B6S6 A0A0C4DH25 A0A0C4DH73 A0M8Q6 A2KUC3 A2NJV5 A2NXD2 O14733 O75791 P01100 P01111 P01112 P01593 P01594 P01597 P01599 P01601 P01602 P01611 P01614 P01615 P01619 P01624 P01699 P01700 P01701 P01703 P01704 P01705 P01706 P01709 P01714 P01715 P01717 P01718 P01721 P01742 P01743 P01762 P01763 P01764 P01766 P01767 P01768 P01772 P01780 P01782 P01814 P01817 P01824 P01825 P01834 P01854 P04211 P04430 P04432 P04433 P05412 P06310 P06312 P06315 P06331 P07948 P0CF74 P0CG04 P0DOY2 P0DOY3 P15498 P16885 P19174 P23083 P27361 P28482 P43405 P45983 P45984 P45985 P52735 P53779 P63000 P80748 Q07889 Q13094 Q13153 Q13177 Q13233 Q5NV61 Q5NV62 Q5NV64 Q5NV65 Q5NV66 Q5NV67 Q5NV68 Q5NV69 Q5NV75 Q5NV79 Q5NV80 Q5NV81 Q5NV82 Q5NV83 Q5NV84 Q5NV85 Q5NV86 Q5NV87 Q5NV89 Q5NV90 Q5NV91 Q5NV92 Q6PIL0 Q9UKW4	ERK1 ERK2 FOS G0S7 GADS GRAP2 GRB2L GRID HRAS HRAS1 IGHE IGHV IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGHV7-81 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 JNK1 JNK2 JNK3 JNK3A JNKK1 JNKK2 JTK8 JUN LCP2 LYN MAP2K4 MAP2K7 MAP3K1 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MAPKKK1 MEK4 MEK7 MEKK MEKK1 MKK4 MKK7 NRAS PAK1 PAK2 PLC1 PLCG1 PLCG2 PRKM1 PRKM10 PRKM2 PRKM3 PRKM8 PRKM9 PRKMK4 PRKMK7 RAC1 SAPK1 SAPK1A SAPK1B SAPK1C SEK1 SERK1 SKK1 SKK4 SOS1 SYK TC25 V1-11 V1-13 V1-16 V1-20 V1-3 V1-5 V1-7 V1-9 V2-11 V2-15 V2-17 V2-19 V2-8 V3-2 V3-3 V3-4 V4-1 V4-2 V4-6 V5-1 V5-4 V5-6 VAV VAV1 VAV2 VAV3	Homo sapiens (human)
Adrenaline signalling through Alpha-2 adrenergic receptor	Alpha-2A adrenergic receptor Alpha-2B adrenergic receptor Alpha-2C adrenergic receptor	P08913 P18089 P18825	ADRA2A ADRA2B ADRA2C ADRA2L1 ADRA2L2 ADRA2R ADRA2RL1 ADRA2RL2 ADRAR	Homo sapiens (human)
Metabolism of folate and pterines	5-formyltetrahydrofolate cyclo-ligase Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial C-1-tetrahydrofolate synthase, cytoplasmic Cytosolic 10-formyltetrahydrofolate dehydrogenase Dihydrofolate reductase 2, mitochondrial Dihydrofolate reductase Folate receptor beta Methylenetetrahydrofolate reductase (NADPH) Mitochondrial 10-formyltetrahydrofolate dehydrogenase Monofunctional C1-tetrahydrofolate synthase, mitochondrial Proton-coupled folate transporter Reduced folate transporter Serine hydroxymethyltransferase, cytosolic Serine hydroxymethyltransferase, mitochondrial Solute carrier family 25 member 32	O75891 P00374 P11586 P13995 P14207 P34896 P34897 P41440 P42898 P49914 Q3SY69 Q6UB35 Q86XF0 Q96NT5 Q9H2D1 Q9H903	ALDH1L1 ALDH1L2 DHFR DHFR2 DHFRL1 DHFRP4 FLOT1 FOLR2 FTHFD FTHFSDC1 G21 HCP1 MFT MFTC MTHFC MTHFD MTHFD1 MTHFD1L MTHFD2 MTHFD2L MTHFR MTHFS NMDMC PCFT RFC1 SHMT1 SHMT2 SLC19A1 SLC25A32 SLC46A1	Homo sapiens (human)
Transport of RCbl within the body	CD320 antigen Low density lipoprotein receptor adapter protein 1 Low-density lipoprotein receptor-related protein 2 Lysosomal cobalamin transport escort protein LMBD1 Lysosomal cobalamin transporter ABCD4 Multidrug resistance-associated protein 1 Transcobalamin-1 Transcobalamin-2	O14678 P20061 P20062 P33527 P98164 Q5SW96 Q9NPF0 Q9NUN5	8D6A ABCC1 ABCD4 ARH C6orf209 CD320 LDLRAP1 LMBRD1 LRP2 MRP MRP1 NESI PXMP1L TC1 TC2 TCN1 TCN2	Homo sapiens (human)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	3 beta-hydroxysteroid dehydrogenase type 7 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase Acyl-coenzyme A thioesterase 8 Aldo-keto reductase family 1 member C1 Aldo-keto reductase family 1 member C2 Aldo-keto reductase family 1 member C3 Aldo-keto reductase family 1 member C4 Aldo-keto reductase family 1 member D1 Alpha-methylacyl-CoA racemase Bile acid receptor Bile acid-CoA Bile salt export pump Cytochrome P450 7A1 Cytochrome P450 7B1 Long-chain fatty acid transport protein 2 Long-chain fatty acid transport protein 5 Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Peroxisomal acyl-coenzyme A oxidase 2 Peroxisomal multifunctional enzyme type 2 Prostacyclin synthase Retinoic acid receptor RXR-alpha Sterol 26-hydroxylase, mitochondrial	O14734 O14975 O75881 O95342 P17516 P19793 P22680 P42330 P51659 P51857 P52895 Q02318 Q04828 Q14032 Q15596 Q15788 Q16647 Q96RI1 Q99424 Q9H2F3 Q9UHK6 Q9UNU6 Q9Y2P5	ABCB11 ACOT8 ACOX2 ACSB ACSVL1 ACSVL6 ACTEIII AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 AMACR BAAT BAR BHLHE74 BHLHE75 BSEP CHDR CYP12 CYP27 CYP27A1 CYP7 CYP7A1 CYP7B1 CYP8 CYP8A1 CYP8B1 DDH DDH1 DDH2 EDH17B4 FACVL1 FACVL3 FATP2 FATP5 FXR HRR1 HSD17B4 HSD17B5 HSD3B7 KIAA0119 NCOA1 NCOA2 NR1H4 NR2B1 PGFS PTE1 PTGIS RIP14 RXRA SDR8C1 SLC27A2 SLC27A5 SRC1 SRC2 SRD5B1 TIF2 VLACS	Homo sapiens (human)
NOSTRIN mediated eNOS trafficking	Actin nucleation-promoting factor WASL Caveolin-1 Dynamin-2 Nitric oxide synthase 3 Nostrin	O00401 P29474 P50570 Q03135 Q8IVI9	CAV CAV1 DNM2 DYN2 NOS3 NOSTRIN WASL	Homo sapiens (human)
RHOH GTPase cycle	Caveolin-1 Drebrin Junction plakoglobin Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial Methionine synthase NSFL1 cofactor p47 Neutral amino acid transporter B(0) Oxysterol-binding protein-related protein 11 Protein FAM91A1 Protein NipSnap homolog 2 Ragulator complex protein LAMTOR1 Ral GTPase-activating protein subunit alpha-1 Ras-related protein Rab-7a Rho GDP-dissociation inhibitor 1 Rho GDP-dissociation inhibitor 2 Rho GDP-dissociation inhibitor 3 Rho-associated protein kinase 1 Rho-associated protein kinase 2 Rho-related GTP-binding protein RhoH Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 4 Serine/threonine-protein kinase PAK 5 Serine/threonine-protein kinase PAK 6 Sodium bicarbonate cotransporter 3 Stomatin Transferrin receptor protein 1 Transitional endoplasmic reticulum ATPase Transmembrane protein 59 Tubulin alpha-1B chain Tyrosine-protein kinase CSK Tyrosine-protein kinase Lck Tyrosine-protein kinase ZAP-70 Uveal autoantigen with coiled-coil domains and ankyrin repeats Vang-like protein 1 Vesicle-associated membrane protein 3 WD repeat-containing protein 11	O75116 O75323 O96013 P02786 P06239 P11182 P14923 P27105 P41240 P43403 P51149 P52565 P52566 P55072 P68363 Q03135 Q13153 Q13177 Q13464 Q15669 Q15758 Q15836 Q16643 Q658Y4 Q6GYQ0 Q6IAA8 Q8TAA9 Q99707 Q99819 Q9BXB4 Q9BXS4 Q9BZF9 Q9BZH6 Q9NQU5 Q9P286 Q9UNZ2 Q9Y6M7	ARHGDIA ARHGDIB ARHGDIG ARHH ASCT2 BCATE2 BCKDHE2 BND7 BRWD2 BT C11orf59 C1orf8 CAV CAV1 CSK CTNNG D0S117E DBN1 DBT DP3 EPB72 FAM91A1 GARNL1 GBAS GDIA1 GDIA2 GDID4 HEL-220 HEL-S-70 JUP KIAA0619 KIAA0884 KIAA1142 KIAA1264 KIAA1351 KIAA1561 LAMTOR1 LCK M7V1 MTR NBC2 NBC2B NBC3 NBCn1 NIPSNAP2 NSFL1C ORP11 OSBP12 OSBPL11 PAK1 PAK2 PAK4 PAK5 PAK6 PAK7 PDRO RAB7 RAB7A RALGAPA1 RAP1GN1 RDR RDRC RHOH ROCK1 ROCK2 SBC2 SLC1A5 SLC4A6 SLC4A7 SRK STB2 STOM SYB3 TFRC TMEM59 TTF TUBA1B TULIP1 UACA UBXN2C VAMP3 VANGL1 VCP WDR11 WDR15 ZAP70	Homo sapiens (human)
PP2A-mediated dephosphorylation of key metabolic factors	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Carbohydrate-responsive element-binding protein Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	P16118 P30153 P30154 P62714 P67775 Q14738 Q9NP71	BHLHD14 F6PK MIO MLXIPL PFKFB1 PFRX PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D WBSCR14	Homo sapiens (human)
Defective ABCA3 causes SMDP3	Phospholipid-transporting ATPase ABCA3	Q99758	ABC3 ABCA3	Homo sapiens (human)
RUNX1 regulates estrogen receptor mediated transcription	Axin-1 BTB/POZ domain-containing protein KCTD6 Core-binding factor subunit beta Estrogen receptor Glycerol-3-phosphate acyltransferase 1, mitochondrial Runt-related transcription factor 1	O15169 P03372 Q01196 Q13951 Q8NC69 Q9HCL2	AML1 AXIN AXIN1 CBFA2 CBFB ESR ESR1 GPAM GPAT1 KCTD6 KIAA1560 NR3A1 RUNX1	Homo sapiens (human)
Downregulation of ERBB2:ERBB3 signaling	E3 ubiquitin-protein ligase NRDP1 Polyubiquitin-B Polyubiquitin-C Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Receptor tyrosine-protein kinase erbB-2 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14511 P04626 P0CG47 P0CG48 P31749 P31751 P40818 P62979 P62987 Q02297 Q9H4P4 Q9Y243	AKT1 AKT2 AKT3 ERBB2 FLRF GGF HER2 HGL HRGA KIAA0055 MLN19 NDF NEU NGL NRDP1 NRG1 NRG2 NTAK PKB PKBG RAC RNF41 RPS27A SMDF UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBPY USP8	Homo sapiens (human)
Retinoid metabolism and transport	Agrin Aldo-keto reductase family 1 member B10 Aldo-keto reductase family 1 member C1 Aldo-keto reductase family 1 member C3 Aldo-keto reductase family 1 member C4 All-trans-retinol 13,14-reductase Apolipoprotein A-I Apolipoprotein A-II Apolipoprotein A-IV Apolipoprotein B-100 Apolipoprotein C-II Apolipoprotein C-III Apolipoprotein E Apolipoprotein M Basement membrane-specific heparan sulfate proteoglycan core protein Beta,beta-carotene 15,15'-dioxygenase Carotenoid-cleaving dioxygenase, mitochondrial Colipase Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 Glypican-1 Glypican-2 Glypican-3 Glypican-4 Glypican-5 Glypican-6 Lecithin retinol acyltransferase Lipoprotein lipase Low-density lipoprotein receptor-related protein 10 Low-density lipoprotein receptor-related protein 12 Low-density lipoprotein receptor-related protein 2 Low-density lipoprotein receptor-related protein 8 Low-density lipoprotein receptor Pancreatic triacylglycerol lipase Phospholipase B1, membrane-associated Prolow-density lipoprotein receptor-related protein 1 Retinol dehydrogenase 11 Retinol-binding protein 1 Retinol-binding protein 2 Retinol-binding protein 4 Syndecan-1 Syndecan-2 Syndecan-3 Syndecan-4 Transthyretin	O00468 O60218 O75056 O75487 O95237 O95445 P01130 P02647 P02649 P02652 P02655 P02656 P02753 P02766 P04114 P04118 P06727 P06858 P09455 P16233 P17516 P18827 P31431 P34741 P35052 P42330 P50120 P51654 P78333 P98160 P98164 Q04828 Q07954 Q14114 Q6NUM9 Q6P1J6 Q7Z4F1 Q8IV16 Q8N158 Q8TC12 Q9BYV7 Q9HAY6 Q9Y561 Q9Y625	A2MR AGRIN AGRN AKR1B10 AKR1B11 AKR1C1 AKR1C3 AKR1C4 APC2 APOA1 APOA2 APOA4 APOB APOC2 APOC3 APOE APOER2 APOM APR ARSDR1 BCDO BCDO1 BCDO2 BCMO1 BCO1 BCO2 CHDR CLPS CRBP1 CRBP2 DDH DDH1 G3A GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GPIHBP1 HBP1 HSD17B5 HSPG1 HSPG2 KIAA0119 KIAA0468 LDLR LIPD LPL LRAT LRP1 LRP10 LRP12 LRP2 LRP8 NG20 OCI5 PALB PGFS PLB PLB1 PNLIP PPSIG PSDR1 RBP1 RBP2 RBP4 RDH11 RETSAT SDC SDC1 SDC2 SDC3 SDC4 SDR7C1 ST7 TTR	Homo sapiens (human)
Assembly and release of respiratory syncytial virus (RSV) virions	Fusion glycoprotein F0 Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Matrix protein Nucleoprotein Phosphoprotein Protein M2-1 RNA-directed RNA polymerase L	P03418 P03420 P03421 P04545 P07900 P08238 P0DOE7 P28887	F HSP90A HSP90AA1 HSP90AB1 HSP90B HSPC1 HSPC2 HSPC3 HSPCA HSPCB L M M2-1 N P	Homo sapiens (human)
Polymerase switching on the C-strand of the telomere	Adrenocortical dysplasia protein homolog CST complex subunit CTC1 CST complex subunit STN1 CST complex subunit TEN1 Chromosome transmission fidelity protein 18 homolog Chromosome transmission fidelity protein 8 homolog DNA polymerase alpha catalytic subunit DNA polymerase alpha subunit B DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA primase large subunit DNA primase small subunit Proliferating cell nuclear antigen Protection of telomeres protein 1 Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Sister chromatid cohesion protein DCC1 TERF1-interacting nuclear factor 2 Telomeric repeat-binding factor 1 Telomeric repeat-binding factor 2-interacting protein 1 Telomeric repeat-binding factor 2	P09884 P0CG13 P12004 P28340 P35249 P35250 P35251 P40937 P40938 P49005 P49642 P49643 P54274 Q14181 Q15054 Q15554 Q2NKJ3 Q86WV5 Q8WVB6 Q96AP0 Q9BSI4 Q9BVC3 Q9H668 Q9HCU8 Q9NUX5 Q9NYB0	ACD C16orf41 C17orf106 C17orf68 CHTF18 CHTF8 CTC1 CTF18 CTF8 DCC1 DRIP5 DSCC1 KIAA0039 OBFC1 PCNA PIN2 PIP1 POLA POLA1 POLA2 POLD POLD1 POLD2 POLD3 POLD4 POLDS POT1 PRIM1 PRIM2 PRIM2A PTOP RAP1 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 STN1 TEN1 TERF1 TERF2 TERF2IP TIN2 TINF2 TINT1 TPP1 TRBF1 TRBF2 TRF TRF1 TRF2	Homo sapiens (human)
G2/M DNA damage checkpoint	ATR-interacting protein BRCA1-A complex subunit Abraxas 1 BRCA1-A complex subunit RAP80 BRCA1-associated RING domain protein 1 BRISC and BRCA1-A complex member 1 BRISC and BRCA1-A complex member 2 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Cell cycle checkpoint control protein RAD9A Cell cycle checkpoint control protein RAD9B Cell cycle checkpoint protein RAD17 Cell cycle checkpoint protein RAD1 Cellular tumor antigen p53 Checkpoint protein HUS1 DNA endonuclease RBBP8 DNA repair protein RAD50 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 2-binding protein 1 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 E3 SUMO-protein ligase PIAS4 E3 ubiquitin-protein ligase HERC2 E3 ubiquitin-protein ligase RNF168 E3 ubiquitin-protein ligase RNF8 Exonuclease 1 Fanconi anemia group J protein Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1t Histone H4 Histone acetyltransferase KAT5 Histone-lysine N-methyltransferase NSD2 Lys-63-specific deubiquitinase BRCC36 Mediator of DNA damage checkpoint protein 1 Nibrin RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Serine/threonine-protein kinase ATR Serine/threonine-protein kinase Chk1 Serine/threonine-protein kinase Chk2 TP53-binding protein 1 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 2	O14757 O60671 O60814 O60921 O60934 O75943 O76064 O95714 O96017 O96028 P04637 P06899 P15927 P16104 P23527 P27694 P33778 P35244 P35249 P35250 P38398 P40937 P40938 P46736 P49959 P51530 P54132 P57053 P58876 P61088 P62805 P62807 Q12888 Q13315 Q13472 Q13535 Q14191 Q14676 Q15819 Q16695 Q16778 Q6UWZ7 Q6WBX8 Q8IYW5 Q8N257 Q8N2W9 Q8WXE1 Q92547 Q92878 Q92993 Q93079 Q96A08 Q96E14 Q96RL1 Q99638 Q99708 Q99728 Q99877 Q99879 Q99880 Q9BSD3 Q9BX63 Q9H9A7 Q9NWV8 Q9NXR7 Q9UQ84	ABRA1 ABRAXAS1 AGS1 ATM ATR ATRIP BABAM1 BABAM2 BACH1 BARD1 BLM BLU BRCA1 BRCC3 BRCC36 BRCC45 BRE BRIP1 C12orf32 C16orf75 C19orf62 C6.1A C9orf76 CCDC98 CDS1 CHEK1 CHEK2 CHK1 CHK2 CTIP CXorf53 DNA2 DNA2L EXO1 EXOI FAM175A FANCJ FRP1 H2AFX H2AX H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-4 H3FT H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HERC2 HEX1 HIRIP1 HIRIP2 HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2BE HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 HNGS1 HTATIP HUS1 KAT5 KIAA0083 KIAA0170 KIAA0259 KIAA0646 KIAA1090 MDC1 MERIT40 MMS2 MMSET MRE11 MRE11A NBA1 NBN NBS NBS1 NFBD1 NSD2 P53 P95 PIAS4 PIASG R24L RAD1 RAD17 RAD50 RAD53 RAD9A RAD9B RAP80 RBBP8 REC1 RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC2 RFC3 RFC4 RFC5 RHINO RHNO1 RMI1 RMI2 RNF168 RNF53 RNF8 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RXRIP110 TIP60 TOP3 TOP3A TOPBP1 TP53 TP53BP1 TRX5 TSH2B UBE2N UBE2V2 UEV2 UIMC1 WHSC1 WRN	Homo sapiens (human)
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	Solute carrier family 12 member 6	Q9UHW9	KCC3 SLC12A6	Homo sapiens (human)
Carnitine metabolism	5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-2 Carnitine O-palmitoyltransferase 1, liver isoform Carnitine O-palmitoyltransferase 1, muscle isoform Carnitine O-palmitoyltransferase 2, mitochondrial Mid1-interacting protein 1 Mitochondrial carnitine/acylcarnitine carrier protein Organic cation/carnitine transporter 2 Peroxisome proliferator-activated receptor delta Retinoic acid receptor RXR-alpha Thyroid hormone-inducible hepatic protein	O43741 O43772 O76082 P19793 P23786 P50416 P54646 Q03181 Q92523 Q92748 Q9NPA3 Q9UGJ0	AMPK AMPK2 CAC CACT CPT1 CPT1A CPT1B CPT2 KIAA1670 MID1IP1 MIG12 NR1C2 NR2B1 OCTN2 PPARB PPARD PRKAA2 PRKAB2 PRKAG2 RXRA SLC22A5 SLC25A20 THRSP	Homo sapiens (human)
Signaling by LRP5 mutants	Dickkopf-related protein 1 Dickkopf-related protein 2 Dickkopf-related protein 4 Kremen protein 1 Kremen protein 2 Low-density lipoprotein receptor-related protein 5	O75197 O94907 Q8NCW0 Q96MU8 Q9UBT3 Q9UBU2	DKK1 DKK2 DKK4 KREMEN KREMEN1 KREMEN2 KRM1 KRM2 LR3 LRP5 LRP7	Homo sapiens (human)
PECAM1 interactions	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Integrin alpha-V Integrin beta-3 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Platelet endothelial cell adhesion molecule Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 6	P05106 P06239 P06241 P06756 P07947 P07948 P16284 P19174 P29350 Q06124 Q92835	FYN GP3A HCP INPP5D ITGAV ITGB3 JTK8 LCK LYN MSK8 PECAM1 PLC1 PLCG1 PTP1C PTP2C PTPN11 PTPN6 SHIP SHIP1 SHPTP2 VNRA VTNR YES YES1	Homo sapiens (human)
FOXO-mediated transcription of cell cycle genes	Caveolin-1 Cyclin-G2 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Forkhead box protein G1 Forkhead box protein O1 Forkhead box protein O3 Forkhead box protein O4 Growth arrest and DNA damage-inducible protein GADD45 alpha Growth/differentiation factor 8 Krueppel-like factor 4 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Poly(rC)-binding protein 4 Protein BTG1 Retinoblastoma-like protein 2	O14793 O43474 O43524 P24522 P38936 P46527 P55316 P57723 P62324 P84022 P98177 Q03135 Q08999 Q12778 Q13485 Q15796 Q16589	AFX AFX1 BTG1 CAP20 CAV CAV1 CCNG2 CDKN1 CDKN1A CDKN1B CIP1 DDIT1 DPC4 EZF FKH2 FKHL1 FKHL2 FKHL3 FKHL4 FKHR FKHRL1 FOXG1 FOXG1A FOXG1B FOXG1C FOXO1 FOXO1A FOXO3 FOXO3A FOXO4 GADD45 GADD45A GDF8 GKLF KIP1 KLF4 MADH2 MADH3 MADH4 MADR2 MDA6 MLLT7 MSTN PCBP4 PIC1 RB2 RBL2 SDI1 SMAD2 SMAD3 SMAD4 WAF1 p27	Homo sapiens (human)
Transport of the SLBP Dependant Mature mRNA	Aladin E3 SUMO-protein ligase RanBP2 Eukaryotic translation initiation factor 4E Histone RNA hairpin-binding protein Nuclear RNA export factor 1 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Nuclear envelope pore membrane protein POM 121 Nuclear envelope pore membrane protein POM 121C Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup133 Nuclear pore complex protein Nup153 Nuclear pore complex protein Nup155 Nuclear pore complex protein Nup160 Nuclear pore complex protein Nup205 Nuclear pore complex protein Nup214 Nuclear pore complex protein Nup50 Nuclear pore complex protein Nup85 Nuclear pore complex protein Nup88 Nuclear pore complex protein Nup93 Nuclear pore glycoprotein p62 Nuclear pore membrane glycoprotein 210 Nucleoporin NDC1 Nucleoporin NUP188 Nucleoporin NUP35 Nucleoporin NUP42 Nucleoporin Nup37 Nucleoporin Nup43 Nucleoporin p54 Nucleoprotein TPR Protein SEC13 homolog THO complex subunit 4 mRNA export factor RAE1	A8CG34 O15504 O75694 P06730 P12270 P35658 P37198 P49790 P49792 P52298 P55735 P57740 P78406 Q09161 Q12769 Q14493 Q5SRE5 Q7Z3B4 Q86V81 Q8N1F7 Q8NFH3 Q8NFH4 Q8NFH5 Q8TEM1 Q8WUM0 Q92621 Q96HA1 Q99567 Q9BTX1 Q9BW27 Q9NRG9 Q9UBU9 Q9UKX7	AAAS ADRACALA ALY ALYREF BEF C7orf14 CAIN CAN CBP20 CBP80 CG1 D3S1231E EIF4E EIF4EL1 EIF4F HBP KIAA0023 KIAA0095 KIAA0169 KIAA0197 KIAA0225 KIAA0618 KIAA0791 KIAA0906 MP44 MRNP41 NCBP NCBP1 NCBP2 NDC1 NPAP60L NUP107 NUP120 NUP121 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP358 NUP37 NUP42 NUP43 NUP50 NUP53 NUP54 NUP62 NUP75 NUP85 NUP88 NUP93 NUPL2 NXF1 PCNT1 POM121 POM121A POM121C RAE1 RANBP2 SEC13 SEC13A SEC13L1 SEC13R SLBP TAP THOC4 TMEM48 TPR	Homo sapiens (human)
NGF-independant TRKA activation	Adenosine receptor A2a BDNF/NT-3 growth factors receptor High affinity nerve growth factor receptor Pituitary adenylate cyclase-activating polypeptide type I receptor Pituitary adenylate cyclase-activating polypeptide	P04629 P18509 P29274 P41586 Q16620	ADCYAP1 ADCYAP1R1 ADORA2 ADORA2A MTC NTRK1 NTRK2 TRK TRKA TRKB	Homo sapiens (human)
Inhibition of Signaling by Overexpressed EGFR	Amphiregulin Epidermal growth factor receptor Epigen Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha	O14944 P00533 P01133 P01135 P15514 P35070 Q6UW88 Q99075	AREG AREGB BTC DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG HBEGF HEGFL HER1 SDGF TGFA	Homo sapiens (human)
Activated NTRK2 signals through PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 BDNF/NT-3 growth factors receptor Brain-derived neurotrophic factor Neurotrophin-4	P19174 P23560 P34130 Q16620	BDNF NTF4 NTF5 NTRK2 PLC1 PLCG1 TRKB	Homo sapiens (human)

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