GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1051 - 1075** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▼	Organism
Homologous DNA Pairing and Strand Exchange	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA repair protein XRCC3 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43542 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2 XRCC3	Homo sapiens (human)
HDR through Homologous Recombination (HRR)	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA polymerase eta DNA polymerase kappa DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA repair protein XRCC3 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O15315 O43502 O43542 O43543 O60934 O75771 P0CG47 P0CG48 P12004 P15927 P27694 P28340 P35244 P35249 P35250 P35251 P38398 P40937 P40938 P49005 P49959 P51530 P51587 P54132 P56282 P60896 P62979 P62987 Q06609 Q07864 Q13315 Q13472 Q14191 Q15054 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9HCU8 Q9NR33 Q9NRF9 Q9UBT6 Q9UQ84 Q9Y253	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CHRAC17 CTIP DINB1 DNA2 DNA2L DPE2 DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0039 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PCNA PIR51 POLD POLD1 POLD2 POLD3 POLD4 POLDS POLE POLE1 POLE2 POLE3 POLE4 POLH POLK RAD30 RAD30A RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RMI1 RMI2 RNF53 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WRN XPV XRCC2 XRCC3	Homo sapiens (human)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA repair protein XRCC3 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Regulator of telomere elongation helicase 1 Serine-protein kinase ATM	O15315 O43502 O43542 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9NZ71 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C20orf41 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 KIAA1088 MRE11 MRE11A NBN NBS NBS1 NHL P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 RTEL1 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2 XRCC3	Homo sapiens (human)
ATF6B (ATF6-beta) activates chaperones	Cyclic AMP-dependent transcription factor ATF-6 beta Endoplasmic reticulum chaperone BiP Membrane-bound transcription factor site-1 protease Membrane-bound transcription factor site-2 protease	O43462 P11021 Q14703 Q99941	ATF6B CREBL1 G13 GRP78 HSPA5 KIAA0091 MBTPS1 MBTPS2 S1P S2P SKI1	Homo sapiens (human)
ATF6 (ATF6-alpha) activates chaperones	Cyclic AMP-dependent transcription factor ATF-6 alpha Endoplasmic reticulum chaperone BiP Membrane-bound transcription factor site-1 protease Membrane-bound transcription factor site-2 protease	O43462 P11021 P18850 Q14703	ATF6 GRP78 HSPA5 KIAA0091 MBTPS1 MBTPS2 S1P S2P SKI1	Homo sapiens (human)
PERK regulates gene expression	Cyclic AMP-dependent transcription factor ATF-4 Endoplasmic reticulum chaperone BiP Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic translation initiation factor 2 subunit 3 Eukaryotic translation initiation factor 2-alpha kinase 3	P05198 P11021 P18848 P20042 P41091 Q9NZJ5	ATF4 CREB2 EIF2A EIF2AK3 EIF2B EIF2G EIF2S1 EIF2S2 EIF2S3 GRP78 HSPA5 PEK PERK TXREB	Homo sapiens (human)
NFE2L2 regulating ER-stress associated genes	CREB-binding protein Cyclic AMP-dependent transcription factor ATF-4 Histone acetyltransferase p300 Nuclear factor erythroid 2-related factor 2 Transcription factor MafK	O60675 P18848 Q09472 Q16236 Q92793	ATF4 CBP CREB2 CREBBP EP300 MAFK NFE2L2 NRF2 P300 TXREB	Homo sapiens (human)
NFE2L2 regulating anti-oxidant/detoxification enzymes	CREB-binding protein Cyclic AMP-dependent transcription factor ATF-4 Cystine/glutamate transporter Extracellular superoxide dismutase [Cu-Zn] Glutamate--cysteine ligase catalytic subunit Glutamate--cysteine ligase regulatory subunit Glutathione S-transferase A1 Glutathione S-transferase A3 Heme oxygenase 1 Histone acetyltransferase p300 NAD(P)H dehydrogenase [quinone] 1 Nuclear factor erythroid 2-related factor 2 Peroxiredoxin-1 Sulfiredoxin-1 Thioredoxin reductase 1, cytoplasmic Thioredoxin Transcription factor MafK Transcription regulator protein BACH1	O14867 O60675 P08263 P08294 P09601 P10599 P15559 P18848 P48506 P48507 Q06830 Q09472 Q16236 Q16772 Q16881 Q92793 Q9BYN0 Q9UPY5	ATF4 BACH1 C20orf139 CBP CREB2 CREBBP DIA4 EP300 GCLC GCLM GLCL GLCLC GLCLR GRIM12 GSTA1 GSTA3 HMOX1 HO HO1 KDRF MAFK NFE2L2 NMOR1 NQO1 NRF2 P300 PAGA PAGB PRDX1 SLC7A11 SOD3 SRX SRX1 SRXN1 TDPX2 TRDX TRX TRX1 TXN TXNRD1 TXREB	Homo sapiens (human)
ATF6 (ATF6-alpha) activates chaperone genes	Calreticulin Cyclic AMP-dependent transcription factor ATF-4 Cyclic AMP-dependent transcription factor ATF-6 alpha DNA damage-inducible transcript 3 protein Endoplasmic reticulum chaperone BiP Endoplasmin Nuclear transcription factor Y subunit alpha Nuclear transcription factor Y subunit beta Nuclear transcription factor Y subunit gamma	P11021 P14625 P18848 P18850 P23511 P25208 P27797 P35638 Q13952	ATF4 ATF6 CALR CHOP CHOP10 CREB2 CRTC DDIT3 GADD153 GRP78 GRP94 HAP3 HSP90B1 HSPA5 HSPC4 NFYA NFYB NFYC TRA1 TXREB	Homo sapiens (human)
Activation of the AP-1 family of transcription factors	Cyclic AMP-dependent transcription factor ATF-2 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Protein c-Fos Transcription factor Jun	P01100 P05412 P15336 P27361 P28482 P45983 P45984 P53779 Q15759 Q16539	ATF2 CREB2 CREBP1 CSBP CSBP1 CSBP2 CSPB1 ERK1 ERK2 FOS G0S7 JNK1 JNK2 JNK3 JNK3A JUN MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MXI2 PRKM1 PRKM10 PRKM11 PRKM2 PRKM3 PRKM8 PRKM9 SAPK1 SAPK1A SAPK1B SAPK1C SAPK2 SAPK2A SAPK2B	Homo sapiens (human)
TP53 Regulates Transcription of DNA Repair Genes	Breast cancer type 1 susceptibility protein CDK-activating kinase assembly factor MAT1 Cellular tumor antigen p53 Cyclic AMP-dependent transcription factor ATF-2 Cyclin-H Cyclin-K Cyclin-T1 Cyclin-T2 Cyclin-dependent kinase 12 Cyclin-dependent kinase 13 Cyclin-dependent kinase 7 Cyclin-dependent kinase 9 DNA damage-binding protein 2 DNA mismatch repair protein Mlh1 DNA mismatch repair protein Msh2 DNA repair protein RAD51 homolog 4 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Elongin-A2 Elongin-A Elongin-B Elongin-C FACT complex subunit SPT16 FACT complex subunit SSRP1 Fanconi anemia group C protein Fanconi anemia group D2 protein Fanconi anemia group I protein General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Mediator of DNA damage checkpoint protein 1 Mismatch repair endonuclease PMS2 Negative elongation factor A Negative elongation factor B Negative elongation factor C/D Negative elongation factor E Protein c-Fos RNA polymerase II elongation factor ELL RNA polymerase II subunit A C-terminal domain phosphatase Serine-protein kinase ATM Serine/threonine-protein kinase ATR Serine/threonine-protein kinase Chk1 Transcription elongation factor A protein 1 Transcription elongation factor SPT4 Transcription elongation factor SPT5 Transcription factor Jun	O00267 O14757 O15514 O60563 O60583 O75771 O75909 P01100 P04637 P05412 P13984 P15336 P18074 P18615 P19387 P19388 P19447 P23193 P24928 P30876 P32780 P35269 P36954 P38398 P40692 P43246 P50613 P50750 P51946 P51948 P52434 P52435 P53803 P54278 P55199 P61218 P62487 P62875 P63272 Q00597 Q08945 Q13315 Q13535 Q13888 Q13889 Q14004 Q14241 Q14676 Q15369 Q15370 Q6ZYL4 Q8IXH7 Q8IYF1 Q8WX92 Q92466 Q92759 Q9BXW9 Q9H3P2 Q9NVI1 Q9NYV4 Q9Y5B0 Q9Y5B9	ATF2 ATM ATR BRCA1 BTF2 BTF2P44 C19orf17 C6orf175 CAK CAK1 CAP35 CCNH CCNK CCNT1 CCNT2 CDC2L CDC2L4 CDC2L5 CDK12 CDK13 CDK7 CDK9 CDKN7 CHED CHEK1 CHK1 COBRA1 COCA2 CPR4 CREB2 CREBP1 CRK7 CRKRS CTDP1 DDB2 ELL ELOA ELOA2 ELOB ELOC ERCC2 ERCC3 FAC FACC FACD FACT140 FACT80 FACTP140 FANCC FANCD2 FANCI FCP1 FOS FRP1 G0S7 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2S JUN KIAA0170 KIAA0904 KIAA1182 KIAA1791 KIAA1794 MAT1 MDC1 MLH1 MNAT1 MO15 MSH2 NELFA NELFB NELFCD NELFD NELFE NFBD1 P53 PMS2 PMSL2 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF RAD51D RAD51L3 RAP30 RAP74 RD RDBP RNF53 RNF66 RPB7 SPT4H SPT5 SPT5H SSRP1 STK1 SUPT16H SUPT4H SUPT4H1 SUPT5H TAK TCEA1 TCEB1 TCEB2 TCEB3 TCEB3B TCEB3L TFIIS TH1 TH1L TP53 TTDA WHSC2 XPB XPBC XPD XPDC	Homo sapiens (human)
CREB phosphorylation	Cyclic AMP-dependent transcription factor ATF-1 MAP kinase-activated protein kinase 2 Ribosomal protein S6 kinase alpha-1 Ribosomal protein S6 kinase alpha-2 Ribosomal protein S6 kinase alpha-3 Ribosomal protein S6 kinase alpha-5	O75582 P18846 P49137 P51812 Q15349 Q15418	ATF1 ISPK1 MAPKAPK1A MAPKAPK1B MAPKAPK1C MAPKAPK2 MSK1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RSK1 RSK2 RSK3	Homo sapiens (human)
Interferon gamma signaling	2'-5'-oligoadenylate synthase 1 2'-5'-oligoadenylate synthase 2 2'-5'-oligoadenylate synthase 3 2'-5'-oligoadenylate synthase-like protein Beta-2-microglobulin CD44 antigen Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma E3 ubiquitin-protein ligase Midline-1 E3 ubiquitin-protein ligase TRIM17 E3 ubiquitin-protein ligase TRIM21 E3 ubiquitin-protein ligase TRIM22 E3 ubiquitin-protein ligase TRIM31 E3 ubiquitin-protein ligase TRIM34 E3 ubiquitin-protein ligase TRIM35 E3 ubiquitin-protein ligase TRIM38 E3 ubiquitin-protein ligase TRIM45 E3 ubiquitin-protein ligase TRIM48 E3 ubiquitin-protein ligase TRIM62 E3 ubiquitin-protein ligase TRIM68 E3 ubiquitin-protein ligase TRIM8 E3 ubiquitin/ISG15 ligase TRIM25 Gamma-interferon-inducible lysosomal thiol reductase Guanylate-binding protein 1 Guanylate-binding protein 2 Guanylate-binding protein 3 Guanylate-binding protein 4 Guanylate-binding protein 5 Guanylate-binding protein 6 Guanylate-binding protein 7 HLA class I histocompatibility antigen, A alpha chain HLA class I histocompatibility antigen, B alpha chain HLA class I histocompatibility antigen, C alpha chain HLA class I histocompatibility antigen, alpha chain E HLA class I histocompatibility antigen, alpha chain F HLA class I histocompatibility antigen, alpha chain G HLA class II histocompatibility antigen, DP alpha 1 chain HLA class II histocompatibility antigen, DP beta 1 chain HLA class II histocompatibility antigen, DQ alpha 1 chain HLA class II histocompatibility antigen, DQ alpha 2 chain HLA class II histocompatibility antigen, DQ beta 1 chain HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DR alpha chain HLA class II histocompatibility antigen, DR beta 3 chain HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DRB1 beta chain High affinity immunoglobulin gamma Fc receptor I Intercellular adhesion molecule 1 Interferon gamma receptor 1 Interferon gamma receptor 2 Interferon gamma Interferon regulatory factor 1 Interferon regulatory factor 2 Interferon regulatory factor 3 Interferon regulatory factor 4 Interferon regulatory factor 5 Interferon regulatory factor 6 Interferon regulatory factor 7 Interferon regulatory factor 8 Interferon regulatory factor 9 MHC class II transactivator Metallothionein-2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mothers against decapentaplegic homolog 7 Neural cell adhesion molecule 1 Nuclear autoantigen Sp-100 Platelet-activating factor receptor Protein PML Protein kinase C delta type Putative HLA class I histocompatibility antigen, alpha chain H Putative high affinity immunoglobulin gamma Fc receptor IB Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tripartite motif-containing protein 10 Tripartite motif-containing protein 14 Tripartite motif-containing protein 26 Tripartite motif-containing protein 29 Tripartite motif-containing protein 2 Tripartite motif-containing protein 3 Tripartite motif-containing protein 46 Tripartite motif-containing protein 5 Tripartite motif-containing protein 6 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 6 Vascular cell adhesion protein 1 Y-box-binding protein 1	O00635 O14543 O14896 O15105 O15344 O15524 O60674 O75382 P00973 P01579 P01889 P01893 P01903 P01906 P01909 P01911 P01920 P02795 P04439 P04440 P05362 P05538 P10321 P10914 P12314 P13284 P13591 P13747 P13762 P14316 P15260 P16070 P17693 P19320 P19474 P20036 P23458 P23497 P25105 P27361 P28482 P29350 P29590 P29728 P30511 P32455 P32456 P33076 P38484 P61769 P67809 P79483 Q00978 Q02556 Q05655 Q12899 Q13554 Q13555 Q13557 Q13568 Q14134 Q14142 Q14258 Q14653 Q15306 Q15646 Q30154 Q6AZZ1 Q6ZN66 Q7Z4K8 Q8IWZ4 Q8IYM9 Q8N8V2 Q92637 Q92985 Q96PP8 Q96PP9 Q9BVG3 Q9BYJ4 Q9BZR9 Q9BZY9 Q9C030 Q9C035 Q9C040 Q9H0R5 Q9H8W5 Q9UDY6 Q9UPQ4 Q9UQM7 Q9Y577 Q9Y6K5	ATDC B2M BERP C6orf13 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CD44 CES1 CIITA CIS3 EFP ERK1 ERK2 FCG1 FCGR1 FCGR1A FCGR1B FCGR1BP FXY GBP1 GBP2 GBP3 GBP4 GBP4L GBP5 GBP6 GBP7 GC109 GERP GILT HCP HLA-5.4 HLA-6.0 HLA-6.2 HLA-A HLA-B HLA-C HLA-DP1A HLA-DP1B HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRA1 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-DXA HLA-DXB HLA-E HLA-F HLA-G HLA-H HLAA HLAB HLAC HLAE HLAF HLAG HLAH HLASB HLS5 ICAM1 ICSBP1 IFI30 IFNG IFNGR1 IFNGR2 IFNGT1 IFP1 IGFR1 IGFRB IP30 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 ISGF3G JAK1 JAK1A JAK1B JAK2 KIAA0129 KIAA0517 KIAA0968 KIAA1098 LHR MADH7 MADH8 MAPK1 MAPK3 MDU2 MDU3 MHC2TA MIC4 MID1 MT2 MT2A MUM1 MYL NCAM NCAM1 NSEP1 OAS1 OAS2 OAS3 OASL OIAS PAFR PKCD PML PP8675 PRKCD PRKM1 PRKM2 PRKM3 PTAFR PTP1C PTPN6 RBCC RFB30 RNF RNF101 RNF137 RNF147 RNF15 RNF16 RNF21 RNF22 RNF27 RNF59 RNF71 RNF81 RNF86 RNF88 RNF89 RNF9 RNF94 RNF95 RNF97 RNF99 RO52 RORET SMAD7 SOCS1 SOCS3 SP100 SS56 SSA1 SSI1 SSI3 STAF50 TERF TIP3 TRIFIC TRIM10 TRIM14 TRIM17 TRIM18 TRIM19 TRIM2 TRIM21 TRIM22 TRIM25 TRIM26 TRIM29 TRIM3 TRIM31 TRIM34 TRIM35 TRIM38 TRIM45 TRIM46 TRIM48 TRIM5 TRIM6 TRIM62 TRIM68 TRIM8 TRIP14 VCAM1 XPRF YB1 YBX1 ZNF147 ZNF173	Homo sapiens (human)
Cilium Assembly	Alpha-tubulin N-acetyltransferase 1 Histone deacetylase 6	Q5SQI0 Q9UBN7	ATAT1 C6orf134 HDAC6 KIAA0901 MEC17	Homo sapiens (human)
Astrocytic Glutamate-Glutamine Uptake And Metabolism	Excitatory amino acid transporter 1 Excitatory amino acid transporter 2 Glutamine synthetase Sodium-coupled neutral amino acid symporter 1	P15104 P43003 P43004 Q9H2H9	ATA1 EAAT1 EAAT2 GLAST GLAST1 GLNS GLT1 GLUL NAT2 SAT1 SLC1A2 SLC1A3 SLC38A1 SNAT1	Homo sapiens (human)
Common Pathway of Fibrin Clot Formation	Antithrombin-III CD177 antigen Coagulation factor V Coagulation factor VIII Coagulation factor X Coagulation factor XIII A chain Coagulation factor XIII B chain Endothelial protein C receptor Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Glia-derived nexin Heparin cofactor 2 Myeloblastin Plasma serine protease inhibitor Platelet factor 4 variant Platelet factor 4 Proteinase-activated receptor 1 Prothrombin Thrombomodulin Vitamin K-dependent protein C Vitamin K-dependent protein S	P00451 P00488 P00734 P00742 P01008 P02671 P02675 P02679 P02776 P04070 P05154 P05160 P05546 P07093 P07204 P07225 P10720 P12259 P24158 P25116 Q8N6Q3 Q9UNN8	AT3 CD177 CF2R CXCL4 CXCL4V1 EPCR F10 F13A F13A1 F13B F2 F2R F5 F8 F8C FGA FGB FGG HCF2 MBN NB1 PAR1 PCI PF4 PF4V1 PI7 PLANH3 PN1 PROC PROCI PROCR PROS PROS1 PRTN3 PRV1 SCYB4 SCYB4V1 SERPINA5 SERPINC1 SERPIND1 SERPINE2 THBD THRM TR	Homo sapiens (human)
Synaptic adhesion-like molecules	Disks large homolog 1 Disks large homolog 3 Disks large homolog 4 Flotillin-1 Flotillin-2 Glutamate receptor 1 Glutamate receptor 3 Glutamate receptor 4 Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2A Glutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic, NMDA 2D Leucine-rich repeat and fibronectin type III domain-containing protein 1 Leucine-rich repeat and fibronectin type-III domain-containing protein 2 Leucine-rich repeat and fibronectin type-III domain-containing protein 3 Leucine-rich repeat and fibronectin type-III domain-containing protein 4 Receptor-type tyrosine-protein phosphatase F Receptor-type tyrosine-protein phosphatase S Receptor-type tyrosine-protein phosphatase delta Reticulon-3	O15399 O75955 O95197 P10586 P23468 P42261 P42263 P48058 P78352 Q05586 Q12879 Q12959 Q13224 Q13332 Q14254 Q14957 Q6PJG9 Q92796 Q9BTN0 Q9P244 Q9ULH4	ASYIP DLG1 DLG3 DLG4 ESA1 FLOT1 FLOT2 GLUA1 GLUH1 GLUR1 GLUR3 GLUR4 GLURC GRIA1 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GluA3 GluA4 GluN2D KIAA1232 KIAA1246 KIAA1484 LAR LRFN1 LRFN2 LRFN3 LRFN4 M17S1 NMDAR1 NMDAR2A NMDAR2B NMDAR2C NMDAR2D NSPL2 PSD95 PTPRD PTPRF PTPRS RTN3 SALM1 SALM2 SALM3 SALM4	Homo sapiens (human)
Activation of PUMA and translocation to mitochondria	Apoptosis-stimulating of p53 protein 1 Apoptosis-stimulating of p53 protein 2 Bcl-2-binding component 3, isoforms 1/2 Cellular tumor antigen p53 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Tumor protein 63 Tumor protein p73	O15350 P04637 Q01094 Q13625 Q14186 Q14188 Q96KQ4 Q9BXH1 Q9H3D4	ASPP1 ASPP2 BBC3 BBP DP1 DP2 E2F1 KET KIAA0771 P53 P63 P73 P73H P73L PPP1R13B PUMA RBBP3 TFDP1 TFDP2 TP53 TP53BP2 TP63 TP73 TP73L	Homo sapiens (human)
Protein hydroxylation	2-oxoglutarate and iron-dependent oxygenase JMJD4 Aspartyl/asparaginyl beta-hydroxylase Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 Bifunctional peptidase and arginyl-hydroxylase JMJD5 Coagulation factor IX Developmentally-regulated GTP-binding protein 1 Developmentally-regulated GTP-binding protein 2 Eukaryotic peptide chain release factor subunit 1 Large ribosomal subunit protein uL15 Large ribosomal subunit protein uL2 Prolyl 3-hydroxylase OGFOD1 RCC1 domain-containing protein 1 RWD domain-containing protein 1 Ribosomal oxygenase 1 Ribosomal oxygenase 2 Small ribosomal subunit protein eS6 Small ribosomal subunit protein uS12 Splicing factor U2AF 65 kDa subunit Zinc finger CCCH domain-containing protein 15	A6NED2 P00740 P0C870 P26368 P46776 P55039 P62266 P62495 P62753 P62917 Q12797 Q6NYC1 Q8IUF8 Q8N371 Q8N543 Q8WU90 Q9H446 Q9H6W3 Q9H9V9 Q9Y295	ASPH BAH C14orf169 DFRP1 DFRP2 DRG1 DRG2 ERF1 ETF1 F9 JMJD4 JMJD5 JMJD6 JMJD7 KDM8 KIAA0585 KIAA1612 LEREPO4 MAPJD MDIG MINA MINA53 NEDD3 NO52 NO66 OGFOD1 PSR PTDSR RCCD1 RF1 RIOX1 RIOX2 RPL27A RPL8 RPS23 RPS6 RWDD1 SUP45L1 TPA1 U2AF2 U2AF65 ZC3H15	Homo sapiens (human)
ATF4 activates genes in response to endoplasmic reticulum stress	Asparagine synthetase [glutamine-hydrolyzing] C-C motif chemokine 2 CCAAT/enhancer-binding protein beta CCAAT/enhancer-binding protein gamma Cyclic AMP-dependent transcription factor ATF-3 Cyclic AMP-dependent transcription factor ATF-4 Cyclic AMP-dependent transcription factor ATF-6 alpha DNA damage-inducible transcript 3 protein Exosome complex component CSL4 Exosome complex component MTR3 Exosome complex component RRP40 Exosome complex component RRP41 Exosome complex component RRP42 Exosome complex component RRP43 Exosome complex component RRP45 Exosome complex component RRP46 Exosome complex component RRP4 Exosome complex exonuclease RRP44 Far upstream element-binding protein 2 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein Insulin-like growth factor-binding protein 1 Interleukin-8 Nuclear transcription factor Y subunit alpha Nuclear transcription factor Y subunit beta Nuclear transcription factor Y subunit gamma Poly(A)-specific ribonuclease PARN m7GpppN-mRNA hydrolase	O95453 P08243 P08833 P10145 P13500 P17676 P18847 P18848 P18850 P23511 P25208 P35638 P53567 Q06265 Q13868 Q13952 Q15011 Q15024 Q5RKV6 Q8IU60 Q92945 Q96B26 Q9NPD3 Q9NQT4 Q9NQT5 Q9Y2L1 Q9Y3B2	ASNS ATF3 ATF4 ATF6 CCL2 CEBPB CEBPG CHOP CHOP10 CML28 CREB2 CSL4 CXCL8 DAN DCP2 DDIT3 DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FUBP2 GADD153 HAP3 HERP HERPUD1 IBP1 IGFBP1 IL8 KHSRP KIAA0025 KIAA0116 KIAA1008 MCP1 MIF1 MTR3 NFYA NFYB NFYC NUDT20 OIP2 PARN PMSCL1 RRP4 RRP40 RRP41 RRP42 RRP43 RRP44 RRP46 SCYA2 SKI6 TCF5 TS11 TXREB	Homo sapiens (human)
Response of EIF2AK1 (HRI) to heme deficiency	Asparagine synthetase [glutamine-hydrolyzing] CCAAT/enhancer-binding protein beta CCAAT/enhancer-binding protein gamma Cyclic AMP-dependent transcription factor ATF-3 Cyclic AMP-dependent transcription factor ATF-4 Cyclic AMP-dependent transcription factor ATF-5 DNA damage-inducible transcript 3 protein Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic translation initiation factor 2 subunit 3 Eukaryotic translation initiation factor 2-alpha kinase 1 Glutathione-specific gamma-glutamylcyclotransferase 1 Growth factor receptor-bound protein 10 Protein phosphatase 1 regulatory subunit 15A Tribbles homolog 3	O75807 P05198 P08243 P17676 P18847 P18848 P20042 P35638 P41091 P53567 Q13322 Q96RU7 Q9BQI3 Q9BUX1 Q9Y2D1	ASNS ATF3 ATF4 ATF5 ATFX BOTCH C20orf97 CEBPB CEBPG CHAC1 CHOP CHOP10 CREB2 DDIT3 EIF2A EIF2AK1 EIF2B EIF2G EIF2S1 EIF2S2 EIF2S3 GADD153 GADD34 GRB10 GRBIR HRI KIAA0207 KIAA1369 NIPK PPP1R15A SKIP3 TCF5 TRB3 TRIB3 TS11 TXREB	Homo sapiens (human)
Response of EIF2AK4 (GCN2) to amino acid deficiency	Asparagine synthetase [glutamine-hydrolyzing] CCAAT/enhancer-binding protein beta CCAAT/enhancer-binding protein gamma Cyclic AMP-dependent transcription factor ATF-2 Cyclic AMP-dependent transcription factor ATF-3 Cyclic AMP-dependent transcription factor ATF-4 DNA damage-inducible transcript 3 protein Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic translation initiation factor 2 subunit 3 Large ribosomal subunit protein P1 Large ribosomal subunit protein P2 Large ribosomal subunit protein eL13 Large ribosomal subunit protein eL14 Large ribosomal subunit protein eL15 Large ribosomal subunit protein eL18 Large ribosomal subunit protein eL19 Large ribosomal subunit protein eL20 Large ribosomal subunit protein eL21 Large ribosomal subunit protein eL22 Large ribosomal subunit protein eL24 Large ribosomal subunit protein eL27 Large ribosomal subunit protein eL28 Large ribosomal subunit protein eL29 Large ribosomal subunit protein eL30 Large ribosomal subunit protein eL31 Large ribosomal subunit protein eL32 Large ribosomal subunit protein eL33 Large ribosomal subunit protein eL34 Large ribosomal subunit protein eL36 Large ribosomal subunit protein eL37 Large ribosomal subunit protein eL38 Large ribosomal subunit protein eL39 Large ribosomal subunit protein eL42 Large ribosomal subunit protein eL43 Large ribosomal subunit protein eL6 Large ribosomal subunit protein eL8 Large ribosomal subunit protein uL10 Large ribosomal subunit protein uL11 Large ribosomal subunit protein uL13 Large ribosomal subunit protein uL14 Large ribosomal subunit protein uL15 Large ribosomal subunit protein uL16 Large ribosomal subunit protein uL18 Large ribosomal subunit protein uL1 Large ribosomal subunit protein uL22 Large ribosomal subunit protein uL23 Large ribosomal subunit protein uL24 Large ribosomal subunit protein uL29 Large ribosomal subunit protein uL2 Large ribosomal subunit protein uL30 Large ribosomal subunit protein uL3 Large ribosomal subunit protein uL4 Large ribosomal subunit protein uL5 Large ribosomal subunit protein uL6 Protein IMPACT Ribosomal protein eL22-like Ribosomal protein eL39-like 2 Ribosomal protein eL42-like Ribosomal protein eS27-like Ribosomal protein uL16-like Ribosomal protein uL24-like Ribosomal protein uL3-like Small ribosomal subunit protein eS10 Small ribosomal subunit protein eS12 Small ribosomal subunit protein eS17 Small ribosomal subunit protein eS19 Small ribosomal subunit protein eS1 Small ribosomal subunit protein eS21 Small ribosomal subunit protein eS24 Small ribosomal subunit protein eS25 Small ribosomal subunit protein eS26 Small ribosomal subunit protein eS27 Small ribosomal subunit protein eS28 Small ribosomal subunit protein eS32 Small ribosomal subunit protein eS4, X isoform Small ribosomal subunit protein eS4, Y isoform 1 Small ribosomal subunit protein eS4, Y isoform 2 Small ribosomal subunit protein eS6 Small ribosomal subunit protein eS7 Small ribosomal subunit protein eS8 Small ribosomal subunit protein uS10 Small ribosomal subunit protein uS11 Small ribosomal subunit protein uS12 Small ribosomal subunit protein uS13 Small ribosomal subunit protein uS14 Small ribosomal subunit protein uS15 Small ribosomal subunit protein uS17 Small ribosomal subunit protein uS19 Small ribosomal subunit protein uS2 Small ribosomal subunit protein uS3 Small ribosomal subunit protein uS4 Small ribosomal subunit protein uS5 Small ribosomal subunit protein uS7 Small ribosomal subunit protein uS8 Small ribosomal subunit protein uS9 Stalled ribosome sensor GCN1 Tribbles homolog 3 Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein eIF-2-alpha kinase GCN2	P05198 P05386 P05387 P05388 P08243 P08708 P08865 P15336 P15880 P17676 P18077 P18124 P18621 P18847 P18848 P20042 P22090 P23396 P25398 P26373 P27635 P30050 P32969 P35268 P35638 P36578 P39019 P39023 P40429 P41091 P42677 P42766 P46776 P46777 P46778 P46779 P46781 P46782 P46783 P47914 P49207 P50914 P53567 P60866 P61247 P61254 P61313 P61353 P61513 P61927 P62081 P62241 P62244 P62249 P62263 P62266 P62269 P62273 P62277 P62280 P62424 P62701 P62750 P62753 P62829 P62841 P62847 P62851 P62854 P62857 P62861 P62888 P62891 P62899 P62906 P62910 P62913 P62917 P62945 P62979 P62987 P63173 P63220 P83731 P83881 P84098 Q02543 Q02878 Q07020 Q6P5R6 Q71UM5 Q8TD47 Q92616 Q92901 Q969Q0 Q96EH5 Q96L21 Q96RU7 Q9P2K8 Q9P2X3 Q9UNX3 Q9Y3U8	ASNS ATF2 ATF3 ATF4 BBC1 C20orf97 CCG2 CEBPB CEBPG CHOP CHOP10 CREB2 CREBP1 D11S2243E D6S218E DDIT3 DXS648E EC45 EIF2A EIF2AK4 EIF2B EIF2G EIF2S1 EIF2S2 EIF2S3 FAU FTE1 GADD153 GCN1 GCN1L1 GCN2 IMPACT KIAA0219 KIAA1338 LAMBR LAMR1 MFTL MPS1 NEDD6 NIPK QM RIG RPL1 RPL10 RPL10A RPL10L RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL22L1 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL26P1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL36AL RPL37 RPL37A RPL38 RPL39 RPL39L RPL39L1 RPL3L RPL4 RPL41 RPL44 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPL9P7 RPL9P8 RPL9P9 RPLP0 RPLP1 RPLP2 RPP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS17L RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS27L RPS28 RPS29 RPS3 RPS3A RPS4 RPS4X RPS4Y RPS4Y1 RPS4Y2 RPS4Y2P RPS5 RPS6 RPS7 RPS8 RPS9 RPSA RRP1 SCAR SKIP3 SURF-3 SURF3 TCF5 TRB3 TRIB3 TS11 TXREB TXREB1 UBA52 UBA80 UBCEP1 UBCEP2	Homo sapiens (human)
Activation of the pre-replicative complex	Cell division control protein 45 homolog Cell division control protein 6 homolog Cell division cycle 7-related protein kinase Cyclin-dependent kinase 2 DNA helicase MCM8 DNA polymerase alpha catalytic subunit DNA polymerase alpha subunit B DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA primase large subunit DNA primase small subunit DNA replication factor Cdt1 DNA replication licensing factor MCM2 DNA replication licensing factor MCM3 DNA replication licensing factor MCM4 DNA replication licensing factor MCM5 DNA replication licensing factor MCM6 DNA replication licensing factor MCM7 Geminin Origin recognition complex subunit 1 Origin recognition complex subunit 2 Origin recognition complex subunit 3 Origin recognition complex subunit 4 Origin recognition complex subunit 5 Origin recognition complex subunit 6 Protein DBF4 homolog A Protein MCM10 homolog Replication protein A 14 kDa subunit Replication protein A 30 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit	O00311 O43913 O43929 O75419 O75496 P09884 P15927 P24941 P25205 P27694 P33991 P33992 P33993 P35244 P49642 P49643 P49736 P56282 Q07864 Q13156 Q13415 Q13416 Q14181 Q14566 Q7L590 Q99741 Q9H211 Q9NR33 Q9NRF9 Q9UBD5 Q9UBU7 Q9UJA3 Q9Y5N6	ASK BM28 C20orf154 CCNL1 CDC18L CDC21 CDC45 CDC45L CDC45L2 CDC46 CDC47 CDC6 CDC7 CDC7L1 CDCL1 CDK2 CDKN2 CDT1 CHRAC17 DBF4 DBF4A DPE2 GMNN KIAA0030 LATHEO MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC1L ORC2 ORC2L ORC3 ORC3L ORC4 ORC4L ORC5 ORC5L ORC6 ORC6L PARC1 POLA POLA1 POLA2 POLE POLE1 POLE2 POLE3 POLE4 PRIM1 PRIM2 PRIM2A REPA1 REPA2 REPA3 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA4 RPA70 ZDBF1	Homo sapiens (human)
Signaling by FLT3 ITD and TKD mutants	GRB2-associated-binding protein 2 GTPase HRas GTPase NRas Growth factor receptor-bound protein 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Receptor-type tyrosine-protein kinase FLT3 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	P01111 P01112 P27986 P36888 P42336 P62993 Q06124 Q07889 Q9UQC2	ASH CD135 FLK2 FLT3 GAB2 GRB1 GRB2 HRAS HRAS1 KIAA0571 NRAS PIK3CA PIK3R1 PTP2C PTPN11 SHPTP2 SOS1 STK1	Homo sapiens (human)
STAT5 activation downstream of FLT3 ITD mutants	Bcl-2-like protein 1 Cyclin-dependent kinase inhibitor 1 GRB2-associated-binding protein 2 Growth factor receptor-bound protein 2 NADPH oxidase 4 Receptor-type tyrosine-protein kinase FLT3 Serine/threonine-protein kinase pim-1 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Tyrosine-protein phosphatase non-receptor type 11	P11309 P36888 P38936 P42229 P51692 P62993 Q06124 Q07817 Q9NPH5 Q9UQC2	ASH BCL2L BCL2L1 BCLX CAP20 CD135 CDKN1 CDKN1A CIP1 FLK2 FLT3 GAB2 GRB2 KIAA0571 MDA6 NOX4 PIC1 PIM1 PTP2C PTPN11 RENOX SDI1 SHPTP2 STAT5 STAT5A STAT5B STK1 WAF1	Homo sapiens (human)

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