GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1201 - 1225** of **2090** in total

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Pathway Name	Protein Name	UniProt ID ▼	Gene Symbol	Organism	GlyTouCan ID
MyD88 dependent cascade initiated on endosome	Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-associated kinase-like 2 Myeloid differentiation primary response protein MyD88 TNF receptor-associated factor 6 Toll-like receptor 7 Toll-like receptor 9	O43187 P51617 Q99836 Q9NR96 Q9NWZ3 Q9NYK1 Q9Y4K3	IRAK IRAK1 IRAK2 IRAK4 MYD88 RNF85 TLR7 TLR9 TRAF6	Homo sapiens (human)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-associated kinase-like 2 Mitogen-activated protein kinase kinase kinase 1 Myeloid differentiation primary response protein MyD88 TNF receptor-associated factor 6 Toll-like receptor 7 Toll-like receptor 9	O43187 P51617 Q13233 Q99836 Q9BQ95 Q9NR96 Q9NWZ3 Q9NYK1 Q9Y4K3	ECSIT IRAK IRAK1 IRAK2 IRAK4 MAP3K1 MAPKKK1 MEKK MEKK1 MYD88 RNF85 TLR7 TLR9 TRAF6	Homo sapiens (human)
MyD88 cascade initiated on plasma membrane	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Flagellin Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-associated kinase-like 2 Mitogen-activated protein kinase kinase kinase 1 Myeloid differentiation primary response protein MyD88 TNF receptor-associated factor 6 Toll-like receptor 10 Toll-like receptor 5	O43187 O60602 P04949 P51617 Q13233 Q99836 Q9BQ95 Q9BXR5 Q9NWZ3 Q9Y4K3	ECSIT IRAK IRAK1 IRAK2 IRAK4 MAP3K1 MAPKKK1 MEKK MEKK1 MYD88 RNF85 TIL3 TLR10 TLR5 TRAF6 flaF fliC hag	Homo sapiens (human)
SARS-CoV-1 activates/modulates innate immune responses	Antiviral innate immune response receptor RIG-I Apoptosis-associated speck-like protein containing a CARD Bone marrow stromal antigen 2 Calcipressin-3 Caspase-1 E3 ubiquitin-protein ligase Itchy homolog E3 ubiquitin/ISG15 ligase TRIM25 Envelope small membrane protein Importin subunit alpha-1 Importin subunit beta-1 Inhibitor of nuclear factor kappa-B kinase subunit epsilon Interferon regulatory factor 3 Interferon-induced helicase C domain-containing protein 1 Interleukin-1 receptor-associated kinase-like 2 Membrane protein Mitochondrial antiviral-signaling protein Mitochondrial import receptor subunit TOM70 N-myc-interactor NACHT, LRR and PYD domains-containing protein 3 NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p105 subunit Nuclear pore complex-interacting protein family member B3 Nucleoprotein ORF3a protein ORF3b protein ORF6 protein ORF7a protein ORF8b protein ORF9b protein Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase B Peptidyl-prolyl cis-trans isomerase FKBP1A Peptidyl-prolyl cis-trans isomerase G Peptidyl-prolyl cis-trans isomerase H Poly(rC)-binding protein 2 Polyubiquitin-B Polyubiquitin-C Pulmonary surfactant-associated protein D Receptor-interacting serine/threonine-protein kinase 3 Replicase polyprotein 1a Replicase polyprotein 1ab Runt-related transcription factor 1 Serine/threonine-protein kinase TBK1 Spike glycoprotein Stimulator of interferon genes protein Suppressor of IKBKE 1 TNF receptor-associated factor 3 TNF receptor-associated factor 6 Toll-like receptor 7 Transcription factor p65 Triokinase/FMN cyclase Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O43187 O43447 O94826 O95786 P0C6U8 P0C6X7 P0CG47 P0CG48 P19838 P23284 P25963 P29466 P35247 P52292 P59594 P59595 P59596 P59632 P59633 P59634 P59635 P59636 P59637 P62937 P62942 P62979 P62987 Q01196 Q04206 Q10589 Q13114 Q13287 Q13427 Q14164 Q14258 Q14653 Q14974 Q15366 Q3LXA3 Q7Z434 Q80H93 Q86WV6 Q92617 Q96J02 Q96P20 Q9BRV8 Q9BYX4 Q9NYK1 Q9UHD2 Q9UKA8 Q9ULZ3 Q9Y4K3 Q9Y572	1a 3a 3b 6 7a 8b 9b AML1 ASC BST2 C1orf7 CAP-1 CARD5 CASP1 CBFA2 CIAS1 COLEC7 CRAF1 CYP20 CYPA CYPB CYPH DAK DDX58 DSCR1L2 E EFP ERIS FKBP1 FKBP12 FKBP1A IFIH1 IKBA IKBKE IKKE IKKI IL1BC IL1BCE IPS1 IRAK2 IRF3 ITCH KIAA0151 KIAA0220 KIAA0719 KIAA1271 KPNA2 KPNB1 M MAD3 MAVS MDA5 MITA N NAK NALP3 NFKB1 NFKB3 NFKBI NFKBIA NLRP3 NMI NPIPB3 NPIPL3 NTF97 PCBP2 PPIA PPIB PPIG PPIH PSPD PYCARD PYPAF1 RCAN3 RCH1 RELA RH116 RIGI RIP3 RIPK3 RNF147 RNF85 RPS27A RUNX1 S SFTP4 SFTPD SIKE SIKE1 SRP1 STING STING1 TBK1 TKFC TLR7 TMEM173 TMS1 TOM70 TOMM70 TOMM70A TRAF3 TRAF6 TRAFAMN TRIM25 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VISA ZNF147 rep sM	Homo sapiens (human)
IRAK2 mediated activation of TAK1 complex	Interleukin-1 receptor-associated kinase-like 2 Mitogen-activated protein kinase kinase kinase 7 Polyubiquitin-B Polyubiquitin-C TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O43187 O43318 P0CG47 P0CG48 P62979 P62987 Q15750 Q8N5C8 Q9NYJ8 Q9Y4K3	IRAK2 KIAA0733 MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 RNF85 RPS27A TAB1 TAB2 TAB3 TAK1 TRAF6 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
activated TAK1 mediates p38 MAPK activation	Dual specificity mitogen-activated protein kinase kinase 3 Dual specificity mitogen-activated protein kinase kinase 6 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase-like 2 MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 3 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Nucleotide-binding oligomerization domain-containing protein 1 Nucleotide-binding oligomerization domain-containing protein 2 Receptor-interacting serine/threonine-protein kinase 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	O43187 O43318 O43353 P46734 P49137 P51617 P52564 P61088 Q13404 Q15750 Q15759 Q16539 Q16644 Q8N5C8 Q9HC29 Q9NYJ8 Q9Y239 Q9Y4K3 Q9Y6K9	BLU CARD15 CARD4 CARDIAK CROC1 CSBP CSBP1 CSBP2 CSPB1 FIP3 IKBKG IRAK IRAK1 IRAK2 KIAA0733 MAP2K3 MAP2K6 MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 MAPK11 MAPK14 MAPKAPK2 MAPKAPK3 MEK3 MEK6 MKK3 MKK6 MXI2 NEMO NOD1 NOD2 PRKM11 PRKMK3 PRKMK6 RICK RIP2 RIPK2 RNF85 SAPK2 SAPK2A SAPK2B SKK2 SKK3 TAB1 TAB2 TAB3 TAK1 TRAF6 UBE2N UBE2V UBE2V1 UEV1	Homo sapiens (human)
Invadopodia formation	Disintegrin and metalloproteinase domain-containing protein 12 Disintegrin and metalloproteinase domain-containing protein 15 Disintegrin and metalloproteinase domain-containing protein 19 SH3 and PX domain-containing protein 2A	O43184 Q13444 Q5TCZ1 Q9H013	ADAM12 ADAM15 ADAM19 FISH KIAA0418 MDC15 MLTN MLTNB SH3MD1 SH3PXD2A TKS5	Homo sapiens (human)
RA biosynthesis pathway	2-aminomuconic semialdehyde dehydrogenase Alcohol dehydrogenase 1A Alcohol dehydrogenase 1C Aldehyde dehydrogenase 1A1 Aldo-keto reductase family 1 member C3 All-trans-retinol dehydrogenase [NAD(+)] ADH4 Cellular retinoic acid-binding protein 1 Cytochrome P450 26A1 Cytochrome P450 26B1 Cytochrome P450 26C1 Dehydrogenase/reductase SDR family member 4 Dehydrogenase/reductase SDR family member 9 Epidermal retinol dehydrogenase 2 Retinal dehydrogenase 2 Retinaldehyde dehydrogenase 3 Retinol dehydrogenase 10 Retinol dehydrogenase 11 Retinol dehydrogenase 13 Retinol dehydrogenase 14 Retinol dehydrogenase 16 Retinol dehydrogenase 5 Short-chain dehydrogenase/reductase 3	O43174 O75452 O75911 O94788 P00326 P00352 P07327 P08319 P29762 P42330 P47895 Q6V0L0 Q8IZV5 Q8N3Y7 Q8NBN7 Q8TC12 Q92781 Q9BPW9 Q9BTZ2 Q9H2A2 Q9HBH5 Q9NR63	ADH1 ADH1A ADH1C ADH2 ADH3 ADH4 AKR1C3 ALDC ALDH1 ALDH12 ALDH1A1 ALDH1A2 ALDH1A3 ALDH6 ALDH8A1 ARSDR1 CRABP1 CYP26 CYP26A1 CYP26A2 CYP26B1 CYP26C1 DDH1 DHRS3 DHRS4 DHRS9 HSD17B5 HSD17B9 KIAA0119 P450RAI1 P450RAI2 PAN2 PGFS PSDR1 PUMB1 RALDH2 RBP5 RDH1 RDH10 RDH11 RDH13 RDH14 RDH15 RDH16 RDH17 RDH5 RDHE2 RODH4 SDR16C1 SDR16C4 SDR16C5 SDR25C2 SDR7C1 SDR7C3 SDR7C4 SDR9C4 SDR9C5 SDR9C8	Homo sapiens (human)
N-Glycan antennae elongation	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A Alpha-2,8-sialyltransferase 8B Alpha-2,8-sialyltransferase 8F Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 Beta-1,4-galactosyltransferase 1 Beta-1,4-galactosyltransferase 2 Beta-1,4-galactosyltransferase 3 Beta-1,4-galactosyltransferase 4 Beta-1,4-galactosyltransferase 5 Beta-1,4-galactosyltransferase 6 Beta-galactoside alpha-2,6-sialyltransferase 1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4	O43173 O43286 O60512 O60513 O60909 P15291 P15907 P61647 Q09328 Q11206 Q92186 Q9UBM8 Q9UBX8 Q9UM21 Q9UQ53	B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CGS23 GGNT5 GGTB2 MGAT4A MGAT4B MGAT4C MGAT5 NANTA3 SIAT1 SIAT4C SIAT8B SIAT8C SIAT8F ST3GAL4 ST6GAL1 ST8SIA2 ST8SIA3 ST8SIA6 STX STZ	Homo sapiens (human)	G81533KY
SIRT1 negatively regulates rRNA expression	Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone-lysine N-methyltransferase SUV39H1 NAD-dependent protein deacetylase sirtuin-1 Ribosomal RNA-processing protein 8 TATA box-binding protein-associated factor RNA polymerase I subunit A TATA box-binding protein-associated factor RNA polymerase I subunit B TATA box-binding protein-associated factor RNA polymerase I subunit C TATA box-binding protein-associated factor RNA polymerase I subunit D TATA-box-binding protein	O43159 O43463 O60814 P04908 P06899 P0C5Y9 P16104 P20226 P20671 P23527 P33778 P57053 P58876 P62805 P62807 P68431 P84243 Q15572 Q15573 Q16777 Q16778 Q53T94 Q6FI13 Q71DI3 Q71UI9 Q8N257 Q93077 Q93079 Q96A08 Q96EB6 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9H5J8	GTF2D1 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 JOSD3 KIAA0409 KMT1A NML RRP8 SIR2L1 SIRT1 SUV39H SUV39H1 TAF1A TAF1B TAF1C TAF1D TBP TF2D TFIID TSH2B	Homo sapiens (human)
Sema4D mediated inhibition of cell attachment and migration	Hepatocyte growth factor receptor Plexin-B1 Ras-related C3 botulinum toxin substrate 1 Ras-related protein R-Ras Rho GTPase-activating protein 35 Rho-related GTP-binding protein Rho6 Semaphorin-4D Transforming protein RhoA	O43157 P08581 P10301 P61586 P63000 Q92730 Q92854 Q9NRY4	ARH12 ARHA ARHGAP35 C9orf164 CD100 GRF1 GRLF1 KIAA0407 KIAA1722 MET P190A PLXN5 PLXNB1 RAC1 RHO12 RHO6 RHOA RND1 RRAS SEMA4D SEMAJ SEP TC25 p190ARHOGAP	Homo sapiens (human)
Oxidative demethylation of DNA	G/T mismatch-specific thymine DNA glycosylase Methylcytosine dioxygenase TET1 Methylcytosine dioxygenase TET2 Methylcytosine dioxygenase TET3	O43151 Q13569 Q6N021 Q8NFU7	CXXC6 KIAA0401 KIAA1546 KIAA1676 LCX TDG TET1 TET2 TET3	Homo sapiens (human)
Modulation by Mtb of host immune system	6 kDa early secretory antigenic target Beta-2-microglobulin Low molecular weight protein-tyrosine phosphatase A Macrophage mannose receptor 1 Phosphate-binding protein PstS 1 Polyubiquitin-B Polyubiquitin-C Possible transcriptional regulatory protein (Probably Lrp/AsnC-family) Toll-like receptor 2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O33321 O60603 P0CG47 P0CG48 P22897 P61769 P62979 P62987 P9WGU1 P9WIA1 P9WNK7	B2M CLEC13D CLEC13DL MRC1 MRC1L1 RPS27A Rv2779c TIL4 TLR2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 esaT6 esxA mptpA phoS1 pstS1 ptpA	Homo sapiens (human)
Ca activated K+ channels	Calcium-activated potassium channel subunit alpha-1 Calcium-activated potassium channel subunit beta-1 Calcium-activated potassium channel subunit beta-2 Calcium-activated potassium channel subunit beta-3 Calcium-activated potassium channel subunit beta-4 Intermediate conductance calcium-activated potassium channel protein 4 Small conductance calcium-activated potassium channel protein 1 Small conductance calcium-activated potassium channel protein 2 Small conductance calcium-activated potassium channel protein 3	O15554 Q12791 Q16558 Q86W47 Q92952 Q9H2S1 Q9NPA1 Q9UGI6 Q9Y691	IK1 IKCA1 K3 KCA4 KCNMA KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 KCNMBL KCNN1 KCNN2 KCNN3 KCNN4 SK SK4 SLO	Homo sapiens (human)
The NLRP3 inflammasome	Alpha-hemolysin Amyloid-beta precursor protein Apoptosis-associated speck-like protein containing a CARD Caspase-1 Heat shock protein HSP 90-beta Heme oxygenase 1 NACHT, LRR and PYD domains-containing protein 3 Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p105 subunit P2X purinoceptor 7 Pannexin-1 Proline-serine-threonine phosphatase-interacting protein 1 Protein SGT1 homolog Pyrin Thioredoxin-interacting protein Thioredoxin Transcription factor p65	O15553 O43586 P05067 P08238 P09601 P09616 P10599 P19838 P29466 Q00653 Q04206 Q96P20 Q96RD7 Q99572 Q9H3M7 Q9ULZ3 Q9Y2Z0	A4 AD1 APP ASC C1orf7 CARD5 CASP1 CD2BP1 CIAS1 HMOX1 HO HO1 HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IL1BC IL1BCE LYT10 MEF MEFV MRS1 NALP3 NFKB1 NFKB2 NFKB3 NLRP3 P2RX7 PANX1 PSTPIP1 PYCARD PYPAF1 RELA SUGT1 TMS1 TRDX TRIM20 TRX TRX1 TXN TXNIP VDUP1 hla hly	Homo sapiens (human)
Purinergic signaling in leishmaniasis infection	5'-nucleotidase Apoptosis-associated speck-like protein containing a CARD C3a anaphylatoxin chemotactic receptor Caspase-1 Cathepsin G Complement C3 Ectonucleoside triphosphate diphosphohydrolase 1 Gasdermin-D Heat shock protein HSP 90-beta Heme oxygenase 1 Interleukin-1 alpha Interleukin-1 beta Interleukin-18 NACHT, LRR and PYD domains-containing protein 3 Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p105 subunit Nucleoside diphosphate phosphatase ENTPD5 P2X purinoceptor 4 P2X purinoceptor 7 Proline-serine-threonine phosphatase-interacting protein 1 Protein SGT1 homolog Pyrin Thioredoxin-interacting protein Thioredoxin Transcription factor p65	O15553 O43586 O75356 P01024 P01583 P01584 P08238 P08311 P09601 P10599 P19838 P21589 P29466 P49961 P57764 Q00653 Q04206 Q14116 Q16581 Q96P20 Q99571 Q99572 Q9H3M7 Q9ULZ3 Q9Y2Z0	ASC AZ3B C1orf7 C3 C3AR1 C3R1 CARD5 CASP1 CD2BP1 CD39 CD39L4 CIAS1 CPAMD1 CTSG DFNA5L ENTPD1 ENTPD5 GSDMD GSDMDC1 HMOX1 HNFAG09 HO HO1 HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IGIF IL18 IL1A IL1B IL1BC IL1BCE IL1F1 IL1F2 IL1F4 LYT10 MEF MEFV NALP3 NFKB1 NFKB2 NFKB3 NLRP3 NT5 NT5E NTE P2RX4 P2RX7 PCPH PSTPIP1 PYCARD PYPAF1 RELA SUGT1 TMS1 TRDX TRIM20 TRX TRX1 TXN TXNIP VDUP1	Homo sapiens (human)
Platelet homeostasis	P2X purinoceptor 1 P2X purinoceptor 2 P2X purinoceptor 3 P2X purinoceptor 4 P2X purinoceptor 5 P2X purinoceptor 6 P2X purinoceptor 7 Platelet-activating factor acetylhydrolase 2, cytoplasmic	O15547 P51575 P56373 Q93086 Q99487 Q99571 Q99572 Q9UBL9	P2RX1 P2RX2 P2RX3 P2RX4 P2RX5 P2RX6 P2RX7 P2RXL1 P2X1 P2X2 P2X5 P2X5FL P2X6 PAFAH2	Homo sapiens (human)
Elevation of cytosolic Ca2+ levels	Calcium release-activated calcium channel protein 1 Inositol 1,4,5-trisphosphate receptor type 2 Inositol 1,4,5-trisphosphate receptor type 3 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 P2X purinoceptor 1 P2X purinoceptor 2 P2X purinoceptor 3 P2X purinoceptor 4 P2X purinoceptor 5 P2X purinoceptor 6 P2X purinoceptor 7 Protein orai-2 Short transient receptor potential channel 3 Short transient receptor potential channel 6 Short transient receptor potential channel 7 Stromal interaction molecule 1	O15547 P51575 P56373 Q13507 Q13586 Q14571 Q14573 Q14643 Q93086 Q96D31 Q96SN7 Q99571 Q99572 Q9HCX4 Q9UBL9 Q9Y210	C7orf19 CBCIP2 CRACM1 GOK INSP3R1 ITPR1 ITPR2 ITPR3 ORAI1 ORAI2 P2RX1 P2RX2 P2RX3 P2RX4 P2RX5 P2RX6 P2RX7 P2RXL1 P2X1 P2X2 P2X5 P2X5FL P2X6 STIM1 TMEM142A TMEM142B TRP3 TRP6 TRP7 TRPC3 TRPC6 TRPC7	Homo sapiens (human)
NOTCH3 Intracellular Domain Regulates Transcription	CREB-binding protein Disks large-associated protein 5 Fatty acid-binding protein, brain Hairy/enhancer-of-split related with YRPW motif protein 1 Hairy/enhancer-of-split related with YRPW motif protein 2 Hairy/enhancer-of-split related with YRPW motif-like protein Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone acetyltransferase p300 Mastermind-like domain-containing protein 1 Mastermind-like protein 1 Mastermind-like protein 2 Mastermind-like protein 3 Neurogenic locus notch homolog protein 1 Neurogenic locus notch homolog protein 3 Plexin-D1 Pre T-cell antigen receptor alpha Pre-B-cell leukemia transcription factor 1 Protein KIBRA Recombining binding protein suppressor of hairless SNW domain-containing protein 1 Signal transducer and activator of transcription 1-alpha/beta Transcription factor HES-1 Transcription factor HES-5	O15540 P40424 P42224 P46531 Q06330 Q09472 Q13495 Q13573 Q14469 Q15398 Q5TA89 Q6ISU1 Q8IX03 Q8IZL2 Q92585 Q92793 Q92830 Q92831 Q96JK9 Q9NQ87 Q9UBP5 Q9UM47 Q9Y4D7 Q9Y5J3	BHLHB31 BHLHB32 BHLHB33 BHLHB38 BHLHB39 BLBP CBP CG1 CHF1 CHF2 CREBBP CXorf6 DLG7 DLGAP5 EP300 FABP7 FABPB GCN5 GCN5L2 GRL HERP HERP1 HERP2 HES1 HES5 HESR1 HEY1 HEY2 HEYL HL HRT1 HRT2 HRT3 HRY IGKJRB IGKJRB1 KAT2A KAT2B KIAA0008 KIAA0200 KIAA0620 KIAA0869 KIAA1816 KIAA1819 KIBRA MAML1 MAML2 MAML3 MAMLD1 MRG NOTCH1 NOTCH3 P300 PBX1 PCAF PLXND1 PRL PTCRA RBPJ RBPJK RBPSUH SKIIP SKIP SNW1 STAT1 TAN1 WWC1	Homo sapiens (human)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Antigen peptide transporter 1 Antigen peptide transporter 2 Beclin 1-associated autophagy-related key regulator Beclin-1 Beta-2-microglobulin Calnexin Calreticulin Endoplasmic reticulum aminopeptidase 1 Endoplasmic reticulum aminopeptidase 2 Endoplasmic reticulum chaperone BiP HLA class I histocompatibility antigen, A alpha chain HLA class I histocompatibility antigen, B alpha chain HLA class I histocompatibility antigen, C alpha chain HLA class I histocompatibility antigen, alpha chain E HLA class I histocompatibility antigen, alpha chain F HLA class I histocompatibility antigen, alpha chain G ORF8 protein Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 Protein SEC13 homolog Protein disulfide-isomerase A3 Protein transport protein Sec23A Protein transport protein Sec24A Protein transport protein Sec24B Protein transport protein Sec24C Protein transport protein Sec24D Protein transport protein Sec31A Putative HLA class I histocompatibility antigen, alpha chain H Small COPII coat GTPase SAR1B Tapasin	O15533 O94855 O94979 O95486 O95487 P01889 P01893 P04439 P0DTC8 P10321 P11021 P13747 P17693 P27797 P27824 P30101 P30511 P53992 P55735 P61769 Q03518 Q03519 Q14457 Q15436 Q6P179 Q6ZNE5 Q8NEB9 Q99570 Q9NZ08 Q9Y6B6	8 ABCB2 ABCB3 APPILS ARTS1 ATG14 ATG14L B2M BECN1 CALR CANX CRTC D3S1231E ERAP1 ERAP2 ERP57 ERP60 GRP58 GRP78 GT197 HLA-5.4 HLA-6.0 HLA-6.2 HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G HLA-H HLAA HLAB HLAC HLAE HLAF HLAG HLAH HSPA5 KIAA0079 KIAA0525 KIAA0755 KIAA0831 KIAA0905 LRAP NGS17 PDIA3 PIK3C3 PIK3R4 PSF1 PSF2 RING11 RING4 SAR1B SARA2 SARB SEC13 SEC13A SEC13L1 SEC13R SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SEC31L1 TAP1 TAP2 TAPA TAPBP VPS15 VPS34 Y1 Y3	Homo sapiens (human)
Activation of PKB	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 RAC-beta serine/threonine-protein kinase Tribbles homolog 3	O15530 P31751 Q5T1C6 Q96RU7	AKT2 C20orf97 CTMP NIPK PDK1 PDPK1 SKIP3 THEM4 TRB3 TRIB3	Homo sapiens (human)
RSK activation	3-phosphoinositide-dependent protein kinase 1 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Ribosomal protein S6 kinase alpha-1 Ribosomal protein S6 kinase alpha-2 Ribosomal protein S6 kinase alpha-3 Ribosomal protein S6 kinase alpha-6	O15530 P27361 P28482 P51812 Q15349 Q15418 Q9UK32	ERK1 ERK2 ISPK1 MAPK1 MAPK3 MAPKAPK1A MAPKAPK1B MAPKAPK1C PDK1 PDPK1 PRKM1 PRKM2 PRKM3 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RSK1 RSK2 RSK3 RSK4	Homo sapiens (human)
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 3-phosphoinositide-dependent protein kinase 1 Caveolin-1 Membrane protein Nucleoprotein ORF3a protein RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase	O15530 P0DTC3 P0DTC5 P0DTC9 P27348 P31749 P31751 P31946 P31947 P61981 P62258 P63104 Q03135 Q04917 Q9Y243	3a AKT1 AKT2 AKT3 CAV CAV1 HME1 M N PDK1 PDPK1 PKB PKBG RAC SFN YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	Homo sapiens (human)
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 26S proteasome regulatory subunit 10B 3-phosphoinositide-dependent protein kinase 1 Caveolin-1 Histone acetyltransferase p300 Membrane protein Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Nucleoprotein ORF3a protein SUMO-conjugating enzyme UBC9 Transcription factor Sp1	O15530 P08047 P27348 P31946 P31947 P59595 P59596 P59632 P61981 P62258 P62333 P63104 P63279 P84022 Q03135 Q04917 Q09472 Q13485	3a CAV CAV1 DPC4 EP300 HME1 M MADH3 MADH4 N P300 PDK1 PDPK1 PSMC6 SFN SMAD3 SMAD4 SP1 SUG2 TSFP1 UBC9 UBCE9 UBE2I YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	Homo sapiens (human)
Estrogen-stimulated signaling through PRKCZ	3-phosphoinositide-dependent protein kinase 1 GTPase HRas GTPase NRas Mitogen-activated protein kinase 1 Protein kinase C zeta type	O15530 P01111 P01112 P28482 Q05513	ERK2 HRAS HRAS1 MAPK1 NRAS PDK1 PDPK1 PKC2 PRKCZ PRKM1 PRKM2	Homo sapiens (human)

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