GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1376 - 1400** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism ▲
SHC-mediated cascade:FGFR4	Beta-klotho Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 GTPase HRas GTPase NRas Son of sevenless homolog 1	O43320 O76093 O95750 P01111 P01112 P05230 P08620 P09038 P10767 P22455 P31371 Q07889 Q86Z14 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF9 FGFA FGFB FGFR4 HRAS HRAS1 HST HST2 HSTF1 HSTF2 HYPF JTK2 KLB KS3 NRAS SOS1 TKF	Homo sapiens (human)
Activation of AMPA receptors	Glutamate receptor 1 Glutamate receptor 2 Glutamate receptor 3 Glutamate receptor 4	P42261 P42262 P42263 P48058	GLUA1 GLUH1 GLUR1 GLUR2 GLUR3 GLUR4 GLURC GRIA1 GRIA2 GRIA3 GRIA4 GluA2 GluA3 GluA4	Homo sapiens (human)
Signaling by FGFR2 amplification mutants	Fibroblast growth factor receptor 2	P21802	BEK FGFR2 KGFR KSAM	Homo sapiens (human)
Synthesis of PIPs at the plasma membrane	ADP-ribosylation factor 1 Cytoplasmic tyrosine-protein kinase BMX Inositol polyphosphate 4-phosphatase type II Inositol polyphosphate 5-phosphatase K Inositol polyphosphate 5-phosphatase OCRL Inositol polyphosphate-4-phosphatase type I A Myotubularin-related protein 13 Myotubularin-related protein 14 Myotubularin-related protein 1 Myotubularin-related protein 2 Myotubularin-related protein 3 Myotubularin-related protein 6 Myotubularin-related protein 8 Myotubularin-related protein 9 Myotubularin Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A Phosphatidylinositol 4-kinase type 2-alpha Phosphatidylinositol 4-kinase type 2-beta Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Phosphatidylinositol 4-phosphate 5-kinase type-1 beta Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Phosphoinositide 3-kinase regulatory subunit 5 Phosphoinositide 3-kinase regulatory subunit 6 Pleckstrin homology domain-containing family A member 1 Pleckstrin homology domain-containing family A member 2 Pleckstrin homology domain-containing family A member 3 Pleckstrin homology domain-containing family A member 4 Pleckstrin homology domain-containing family A member 5 Pleckstrin homology domain-containing family A member 6 Pleckstrin homology domain-containing family A member 8 RUN and FYVE domain-containing protein 1 Ras-related protein Rab-14 Ras-related protein Rab-4A Ras-related protein Rab-5A Synaptojanin-1 Synaptojanin-2 Tyrosine-protein phosphatase non-receptor type 13	O00329 O00443 O00459 O00750 O14986 O15056 O15327 O15357 O43426 O60331 O75747 P20338 P20339 P27986 P42336 P42338 P48426 P48736 P51813 P60484 P61106 P78356 P84077 Q01968 Q12923 Q13496 Q13613 Q13614 Q13615 Q15735 Q5UE93 Q86WG5 Q8NCE2 Q8TBX8 Q8TCG2 Q8WYR1 Q92569 Q92835 Q96EF0 Q96JA3 Q96PE3 Q96QG7 Q96T51 Q99755 Q9BT40 Q9BTU6 Q9H4M7 Q9HAU0 Q9HB19 Q9HB20 Q9HB21 Q9Y217 Q9Y2H5	ARF1 BMX C17orf38 C3orf29 C8orf9 CG2 CMT4B2 FAPP1 FAPP2 GRB1 INPP4A INPP4B INPP5D INPP5J INPP5K INPPL1 KIAA0348 KIAA0371 KIAA0589 KIAA0910 KIAA0969 KIAA1073 KIAA1686 KIAA1766 MMAC1 MTM1 MTMR1 MTMR13 MTMR14 MTMR2 MTMR3 MTMR6 MTMR8 MTMR9 OCRL OCRL1 PEPP1 PEPP2 PEPP3 PI4K2A PI4K2B PI5P4KA PIB5PA PIK3C1 PIK3C2A PIK3C2B PIK3C2G PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PIP5K2 PIP5K2A PIP5K2B PIP5K2C PIPP PLEKHA1 PLEKHA2 PLEKHA3 PLEKHA4 PLEKHA5 PLEKHA6 PLEKHA8 PNP1 PPS PTEN PTP1E PTPL1 PTPN13 RAB14 RAB4 RAB4A RAB5 RAB5A RABIP4 RUFY1 SBF2 SHIP SHIP1 SHIP2 SKIP STM7 SYNJ1 SYNJ2 TAPP1 TAPP2 TEP1 ZFYVE10 ZFYVE12	Homo sapiens (human)
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	Gap junction alpha-1 protein	P17302	GJA1 GJAL	Homo sapiens (human)
Defective F9 variant does not activate FX	Coagulation factor IX Coagulation factor VIII Coagulation factor X	P00451 P00740 P00742	F10 F8 F8C F9	Homo sapiens (human)
Aggrephagy	ADP-ribosylation factor-like protein 13B Centrin-1 Cystic fibrosis transmembrane conductance regulator Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoplasmic dynein 1 light intermediate chain 1 Cytoplasmic dynein 1 light intermediate chain 2 Dynein light chain 1, cytoplasmic Dynein light chain 2, cytoplasmic E3 ubiquitin-protein ligase parkin Heat shock factor protein 1 Heat shock protein HSP 90-alpha Histone deacetylase 6 Intraflagellar transport protein 88 homolog Parkinson disease protein 7 Pericentrin Polyubiquitin-B Polyubiquitin-C Transitional endoplasmic reticulum ATPase Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14576 O43237 O60260 O95613 P07900 P0CG47 P0CG48 P13569 P55072 P61088 P62979 P62987 P63167 Q00613 Q12798 Q13099 Q13404 Q13409 Q14204 Q3SXY8 Q96FJ2 Q99497 Q9UBN7 Q9Y6G9	ABCC7 ARL13B ARL2L1 BLU CEN1 CETN CETN1 CFTR CROC1 DHC1 DLC1 DLC2 DNCH1 DNCI1 DNCI2 DNCIC1 DNCIC2 DNCL DNCL1 DNCLC1 DNCLI1 DNCLI2 DNECL DYHC DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 HDAC6 HDLC1 HEL-220 HEL-S-70 HSF1 HSP90A HSP90AA1 HSPC1 HSPCA HSTF1 IFT88 KIAA0325 KIAA0402 KIAA0901 LIC2 PARK2 PARK7 PCNT PCNT2 PRKN RPS27A TG737 TTC10 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBE2N UBE2V UBE2V1 UEV1 VCP	Homo sapiens (human)
Defective AMN causes MGA1	Cobalamin binding intrinsic factor Cubilin Protein amnionless	O60494 P27352 Q9BXJ7	AMN CBLIF CUBN GIF IFCR IFMH	Homo sapiens (human)
TRAF6 mediated IRF7 activation	Antiviral innate immune response receptor RIG-I CREB-binding protein E3 ubiquitin-protein ligase RNF135 E3 ubiquitin-protein ligase TRIM4 E3 ubiquitin/ISG15 ligase TRIM25 Histone acetyltransferase p300 Inhibitor of nuclear factor kappa-B kinase subunit epsilon Interferon alpha-1/13 Interferon alpha-10 Interferon alpha-14 Interferon alpha-16 Interferon alpha-17 Interferon alpha-21 Interferon alpha-2 Interferon alpha-4 Interferon alpha-5 Interferon alpha-6 Interferon alpha-7 Interferon alpha-8 Interferon beta Interferon regulatory factor 3 Interferon regulatory factor 7 Interferon-induced helicase C domain-containing protein 1 Mitochondrial antiviral-signaling protein Serine/threonine-protein kinase TBK1 Suppressor of IKBKE 1 TNF receptor-associated factor 2 TNF receptor-associated factor 6 TRAF family member-associated NF-kappa-B activator	O95786 P01562 P01563 P01566 P01567 P01568 P01569 P01570 P01571 P01574 P05013 P05014 P05015 P32881 Q09472 Q12933 Q14164 Q14258 Q14653 Q7Z434 Q8IUD6 Q92793 Q92844 Q92985 Q9BRV8 Q9BYX4 Q9C037 Q9UHD2 Q9Y4K3	CBP CREBBP DDX58 EFP EP300 IFB IFIH1 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA2A IFNA2B IFNA2C IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB IFNB1 IKBKE IKKE IKKI IPS1 IRF3 IRF7 ITRAF KIAA0151 KIAA1271 MAVS MDA5 NAK P300 RH116 RIGI RNF135 RNF147 RNF85 RNF87 SIKE SIKE1 TANK TBK1 TRAF2 TRAF6 TRAP3 TRIM25 TRIM4 VISA ZNF147	Homo sapiens (human)
Prednisone ADME	11-beta-hydroxysteroid dehydrogenase 1 11-beta-hydroxysteroid dehydrogenase type 2 ATP-dependent translocase ABCB1 Albumin Aldo-keto reductase family 1 member C1 Corticosteroid-binding globulin Cytochrome P450 3A4 UDP-glucuronosyltransferase 1A3 UDP-glucuronosyltransferase 2B17 UDP-glucuronosyltransferase 2B7	O75795 P02768 P08183 P08185 P08684 P16662 P28845 P35503 P80365 Q04828	ABCB1 AKR1C1 ALB CBG CYP3A3 CYP3A4 DDH DDH1 GNT1 HSD11 HSD11B1 HSD11B2 HSD11K HSD11L MDR1 PGY1 SDR26C1 SDR9C3 SERPINA6 UGT1 UGT1A3 UGT2B17 UGT2B7 UGTB2B9	Homo sapiens (human)
TRAF6-mediated induction of TAK1 complex within TLR4 complex	Interleukin-1 receptor-associated kinase-like 2 Lymphocyte antigen 96 Mitogen-activated protein kinase kinase kinase 7 Monocyte differentiation antigen CD14 Polyubiquitin-B Polyubiquitin-C TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TIR domain-containing adapter molecule 1 TIR domain-containing adapter molecule 2 TNF receptor-associated factor 6 Toll-like receptor 4 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00206 O43187 O43318 P08571 P0CG47 P0CG48 P62979 P62987 Q15750 Q86XR7 Q8IUC6 Q8N5C8 Q9NYJ8 Q9Y4K3 Q9Y6Y9	CD14 ESOP1 IRAK2 KIAA0733 LY96 MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 MD2 PRVTIRB RNF85 RPS27A TAB1 TAB2 TAB3 TAK1 TICAM1 TICAM2 TIRAP3 TIRP TLR4 TRAF6 TRAM TRIF UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
ERBB2 Regulates Cell Motility	Epidermal growth factor receptor Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein MEMO1 Protein diaphanous homolog 1 Receptor tyrosine-protein kinase erbB-2 Transforming protein RhoA	O14511 O14944 O60610 P00533 P01133 P04626 P35070 P56975 P61586 Q02297 Q8WWG1 Q99075 Q9Y316	ARH12 ARHA BTC C2orf4 DIAP1 DIAPH1 DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GGF HBEGF HEGFL HER1 HER2 HGL HRGA MEMO MEMO1 MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NS5ATP7 NTAK RHO12 RHOA SMDF	Homo sapiens (human)
MicroRNA (miRNA) biogenesis	DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Endoribonuclease Dicer Exportin-5 GTP-binding nuclear protein Ran Interferon-inducible double-stranded RNA-dependent protein kinase activator A Microprocessor complex subunit DGCR8 Protein argonaute-1 Protein argonaute-2 Protein argonaute-3 Protein argonaute-4 RISC-loading complex subunit TARBP2 RNA 5'-monophosphate methyltransferase Ribonuclease 3	O15514 O75569 P19387 P19388 P24928 P30876 P36954 P52434 P52435 P53803 P61218 P62487 P62826 P62875 Q15633 Q7Z5W3 Q8WYQ5 Q9H9G7 Q9HAV4 Q9HCK5 Q9NRR4 Q9UKV8 Q9UL18 Q9UPY3	AGO1 AGO2 AGO3 AGO4 ARA24 BCDIN3D C22orf12 DGCR8 DGCRK6 DICER DICER1 DROSHA EIF2C1 EIF2C2 EIF2C3 EIF2C4 HERNA KIAA0928 KIAA1291 KIAA1567 PACT POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF PRKRA RAN RANBP21 RAX RN3 RNASE3L RNASEN RPB7 TARBP2 TRBP XPO5	Homo sapiens (human)
PLC-gamma1 signalling	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Beta-nerve growth factor High affinity nerve growth factor receptor	P01138 P04629 P19174	MTC NGF NGFB NTRK1 PLC1 PLCG1 TRK TRKA	Homo sapiens (human)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	Dipeptidyl peptidase 4 Free fatty acid receptor 1 Gastric inhibitory polypeptide Glucose-dependent insulinotropic receptor Insulin gene enhancer protein ISL-1 Neuroendocrine convertase 1 Paired box protein Pax-6 Signal peptidase complex catalytic subunit SEC11A Signal peptidase complex catalytic subunit SEC11C Signal peptidase complex subunit 1 Signal peptidase complex subunit 2 Signal peptidase complex subunit 3 Transcription factor GATA-4	O14842 P09681 P26367 P27487 P29120 P43694 P61009 P61371 P67812 Q15005 Q8TDV5 Q9BY50 Q9Y6A9	ADCP2 AN2 CD26 DPP4 FFAR1 GATA4 GIP GPR119 GPR40 ISL1 KIAA0102 NEC1 PAX6 PCSK1 SEC11A SEC11C SEC11L1 SEC11L3 SPC12 SPC18 SPC21 SPC22 SPC25 SPCS1 SPCS2 SPCS3 SPCS4A SPCS4C	Homo sapiens (human)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	ATP-dependent DNA/RNA helicase DHX36 ATP-dependent RNA helicase A Interferon regulatory factor 7 Myeloid differentiation primary response protein MyD88 Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p105 subunit Transcription factor p65	P19838 Q00653 Q04206 Q08211 Q92985 Q99836 Q9H2U1	DDX36 DDX9 DHX36 DHX9 IRF7 KIAA1488 LKP LYT10 MLEL1 MYD88 NDH2 NFKB1 NFKB2 NFKB3 RELA RHAU	Homo sapiens (human)
Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)	Solute carrier organic anion transporter family member 1B3	Q9NPD5	LST2 OATP1B3 OATP8 SLC21A8 SLCO1B3	Homo sapiens (human)
Abacavir metabolism	Adenosine deaminase-like protein Alcohol dehydrogenase 1A Cytosolic purine 5'-nucleotidase Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	P07327 P35558 P49902 Q6DHV7	ADAL ADAL1 ADH1 ADH1A NT5B NT5C2 NT5CP PCK1 PEPCK1 PNT5	Homo sapiens (human)
Defective CSF2RA causes SMDP4	Cytokine receptor common subunit beta Granulocyte-macrophage colony-stimulating factor receptor subunit alpha Pulmonary surfactant-associated protein A1 Pulmonary surfactant-associated protein A2 Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein D Surfactant protein C Surfactant-associated protein 3	P07988 P0C7M3 P11686 P15509 P32927 P35247 Q8IWL1 Q8IWL2	COLEC4 COLEC5 COLEC7 CSF2R CSF2RA CSF2RB CSF2RY IL3RB IL5RB PSAP PSPD SFTA3 SFTP1 SFTP2 SFTP3 SFTP4 SFTPA SFTPA1 SFTPA1B SFTPA2 SFTPA2B SFTPB SFTPC SFTPD SFTPH	Homo sapiens (human)
Multifunctional anion exchangers	Anion exchange transporter Chloride anion exchanger Pendrin Sodium-coupled monocarboxylate transporter 2 Sodium-independent sulfate anion transporter Solute carrier family 26 member 6 Solute carrier family 26 member 9 Sulfate anion transporter 1 Sulfate transporter	O43511 P40879 P50443 Q1EHB4 Q7LBE3 Q86WA9 Q8TE54 Q9BXS9 Q9H2B4	DRA DTD DTDST PDS SAT1 SLC26A1 SLC26A11 SLC26A2 SLC26A3 SLC26A4 SLC26A6 SLC26A7 SLC26A9 SLC5A12 SMCT2 SUT2	Homo sapiens (human)
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	Agrin Basement membrane-specific heparan sulfate proteoglycan core protein Exostosin-1 Exostosin-2 Glypican-1 Glypican-2 Glypican-3 Glypican-4 Glypican-5 Glypican-6 Syndecan-1 Syndecan-2 Syndecan-3 Syndecan-4	O00468 O75056 O75487 P18827 P31431 P34741 P35052 P51654 P78333 P98160 Q16394 Q8N158 Q93063 Q9Y625	AGRIN AGRN EXT1 EXT2 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 HSPG1 HSPG2 KIAA0468 OCI5 SDC SDC1 SDC2 SDC3 SDC4	Homo sapiens (human)
Endosomal Sorting Complex Required For Transport (ESCRT)	Charged multivesicular body protein 2a Charged multivesicular body protein 2b Charged multivesicular body protein 3 Charged multivesicular body protein 4a Charged multivesicular body protein 4b Charged multivesicular body protein 4c Charged multivesicular body protein 5 Charged multivesicular body protein 6 Charged multivesicular body protein 7 Hepatocyte growth factor-regulated tyrosine kinase substrate Multivesicular body subunit 12A Multivesicular body subunit 12B Polyubiquitin-B Polyubiquitin-C Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Tumor susceptibility gene 101 protein Ubiquitin-associated protein 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Vacuolar protein sorting-associated protein 28 homolog Vacuolar protein sorting-associated protein 37A Vacuolar protein sorting-associated protein 37B Vacuolar protein sorting-associated protein 37C Vacuolar protein sorting-associated protein 37D Vacuolar protein sorting-associated protein 4A Vacuolar protein sorting-associated protein 4B Vacuolar protein sorting-associated protein VTA1 homolog Vacuolar protein-sorting-associated protein 25 Vacuolar protein-sorting-associated protein 36 Vacuolar-sorting protein SNF8	A5D8V6 O14964 O43633 O75351 O75886 P0CG47 P0CG48 P62979 P62987 Q86VN1 Q86XT2 Q8NEZ2 Q8WUX9 Q92783 Q96CF2 Q96EY5 Q96FZ7 Q96H20 Q99816 Q9BRG1 Q9BY43 Q9H444 Q9H7P6 Q9H9H4 Q9NP79 Q9NZ09 Q9NZZ3 Q9UK41 Q9UN37 Q9UQN3 Q9Y3E7	BC2 C13orf9 C14orf123 C20orf178 C6orf55 C9orf28 C9orf83 CFBP CGI149 CHMP2 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CHMP6 CHMP7 DERP9 EAP20 EAP30 EAP45 FAM125A FAM125B HBP HCRP1 HGS HRS MVB12A MVB12B NEDF PML39 RPS27A SHAX1 SHAX2 SHAX3 SKD1 SNF7DC2 SNF8 STAM STAM1 STAM2 TSG101 UBA52 UBA80 UBAP1 UBB UBC UBCEP1 UBCEP2 VPS20 VPS24 VPS25 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D VPS4 VPS42 VPS4A VPS4B VTA1 WBSCR24	Homo sapiens (human)
NOTCH4 Activation and Transmission of Signal to the Nucleus	14-3-3 protein zeta/delta Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Neurogenic locus notch homolog protein 4 Nicastrin Presenilin-1 Presenilin-2 Protein jagged-1	O14672 P49768 P49810 P63104 P78504 Q8WW43 Q92542 Q96BI3 Q99466 Q9NR61 Q9NZ42	AD3 AD4 ADAM10 APH1A APH1B DLL4 INT3 JAG1 JAGL1 KIAA0253 KUZ MADM NCSTN NOTCH4 PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 STM2 YWHAZ	Homo sapiens (human)
U12 Dependent Splicing	116 kDa U5 small nuclear ribonucleoprotein component ATP-dependent RNA helicase DDX42 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Pre-mRNA-processing factor 6 Pre-mRNA-processing-splicing factor 8 Probable ATP-dependent RNA helicase DDX23 Programmed cell death protein 7 RNA-binding region-containing protein 3 Serine/arginine-rich splicing factor 1 Serine/arginine-rich splicing factor 2 Serine/arginine-rich splicing factor 6 Serine/arginine-rich splicing factor 7 Small nuclear ribonucleoprotein E Small nuclear ribonucleoprotein F Small nuclear ribonucleoprotein G Small nuclear ribonucleoprotein Sm D1 Small nuclear ribonucleoprotein Sm D2 Small nuclear ribonucleoprotein Sm D3 Small nuclear ribonucleoprotein-associated proteins B and B' Splicing factor 3B subunit 1 Splicing factor 3B subunit 2 Splicing factor 3B subunit 3 Splicing factor 3B subunit 4 Splicing factor 3B subunit 5 Splicing factor 3B subunit 6 Thioredoxin-like protein 4A U11/U12 small nuclear ribonucleoprotein 25 kDa protein U11/U12 small nuclear ribonucleoprotein 35 kDa protein U11/U12 small nuclear ribonucleoprotein 48 kDa protein U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 U5 small nuclear ribonucleoprotein 200 kDa helicase U5 small nuclear ribonucleoprotein 40 kDa protein Y-box-binding protein 1 Zinc finger CCHC-type and RNA-binding motif-containing protein 1 Zinc finger matrin-type protein 5	O15514 O75533 O75643 O94906 P13984 P14678 P19387 P19388 P24928 P30876 P35269 P36954 P52298 P52434 P52435 P53803 P61218 P62304 P62306 P62308 P62314 P62316 P62318 P62487 P62875 P67809 P83876 Q01130 Q07955 Q09161 Q13247 Q13435 Q15029 Q15393 Q15427 Q15696 Q16560 Q16629 Q6IEG0 Q6P2Q9 Q86XP3 Q8N8D1 Q8TBF4 Q96DI7 Q96LT9 Q9BUQ8 Q9BV90 Q9BWJ5 Q9UDW3 Q9Y3B4	ASCC3L1 ASF BRR2 C16orf33 C20orf14 C6orf151 CBP20 CBP80 COD DDX23 DDX42 DIM1 EFTUD2 GTF2F1 GTF2F2 HELIC2 HM1 KIAA0017 KIAA0031 KIAA0788 KIAA1839 NCBP NCBP1 NCBP2 NSEP1 PBSCF PBSCG PDCD7 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF PRP8BP PRPC8 PRPF6 PRPF8 RAP30 RAP74 RBM40 RNP RNPC3 RPB7 SAP130 SAP14 SAP145 SAP155 SAP49 SF2 SF2P33 SF3B1 SF3B10 SF3B14 SF3B14A SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SFP38 SFRS1 SFRS2 SFRS6 SFRS7 SNRNP200 SNRNP25 SNRNP35 SNRNP40 SNRNP48 SNRNP65 SNRP116 SNRPB SNRPB1 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP55 SRSF1 SRSF2 SRSF6 SRSF7 TXNL4 TXNL4A U1SNRNPBP U2AF1-RS2 U2AF1L2 U2AF1RS2 URP WDR57 YB1 YBX1 ZCRB1 ZMAT5 ZRSR2	Homo sapiens (human)
Signaling by NODAL	Activin receptor type-1B Activin receptor type-1C Activin receptor type-2A Activin receptor type-2B Cerberus Cryptic protein DAN domain family member 5 Dr1-associated corepressor Embryonic growth/differentiation factor 1 Forkhead box protein H1 Forkhead box protein O3 Furin Left-right determination factor 1 Left-right determination factor 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Nodal homolog Proprotein convertase subtilisin/kexin type 6 Protein Cripto Putative protein CRIPTO3	O00292 O43524 O75593 O75610 O95813 P09958 P0CG37 P13385 P27037 P27361 P27539 P28482 P29122 P36896 P51864 P84022 Q13485 Q13705 Q14919 Q15796 Q8N907 Q8NER5 Q96S42	ACVR1B ACVR1C ACVR2 ACVR2A ACVR2B ACVRLK4 ALK4 ALK7 CER1 CER2 CFC1 CKTSF1B3 CRIPTO CRIPTO-1 CRIPTO-3 CRIPTO3 DAND4 DAND5 DPC4 DRAP1 EBAF ERK1 ERK2 FAST1 FAST2 FKHRL1 FOXH1 FOXO3 FOXO3A FUR FURIN GDF1 GREM3 LEFTA LEFTB LEFTY1 LEFTY2 LEFTYA LEFTYB MADH2 MADH3 MADH4 MADR2 MAPK1 MAPK3 NODAL PACE PACE4 PCSK3 PCSK6 PRKM1 PRKM2 PRKM3 SMAD2 SMAD3 SMAD4 SP1 TDGF1 TDGF1P3 TDGF2 TDGF3 TGFB4	Homo sapiens (human)

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