GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1401 - 1425** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▼	Organism	GlyTouCan ID
Defective ALG11 causes CDG-1p	GDP-Man	Q2TAA5	ALG11 GT8	Homo sapiens (human)
Defective ALG1 causes CDG-1k	Chitobiosyldiphosphodolichol beta-mannosyltransferase	Q9BT22	ALG1 HMAT1 HMT1	Homo sapiens (human)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Alpha-1,2-mannosyltransferase ALG9 Alpha-1,3/1,6-mannosyltransferase ALG2 Chitobiosyldiphosphodolichol beta-mannosyltransferase Dol-P-Glc Dol-P-Glc Dol-P-Man Dol-P-Man Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase GDP-Man Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 Mannose-P-dolichol utilization defect 1 protein UDP-N-acetylglucosamine transferase subunit ALG13 UDP-N-acetylglucosamine transferase subunit ALG14 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	O75352 Q2TAA5 Q5BKT4 Q5I7T1 Q92685 Q96AA3 Q96F25 Q9BT22 Q9BV10 Q9BVK2 Q9H3H5 Q9H553 Q9H6U8 Q9NP73 Q9Y672	ALG1 ALG10 ALG10A ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG6 ALG8 ALG9 CXorf45 DIBD1 DPAGT1 DPAGT2 GLT28D1 GT8 HMAT1 HMT1 KCR1 MPDU1 NOT NOT56L RFT1	Homo sapiens (human)
Choline catabolism	Alpha-aminoadipic semialdehyde dehydrogenase Betaine--homocysteine S-methyltransferase 1 Choline dehydrogenase, mitochondrial Choline transporter-like protein 1 Dimethylglycine dehydrogenase, mitochondrial Sarcosine dehydrogenase, mitochondrial	P49419 Q8NE62 Q8WWI5 Q93088 Q9UI17 Q9UL12	ALDH7A1 ATQ1 BHMT CD92 CDW92 CHDH CTL1 DMGDH DMGDHL1 SARDH SLC44A1	Homo sapiens (human)
Carnitine synthesis	4-trimethylaminobutyraldehyde dehydrogenase Gamma-butyrobetaine dioxygenase Serine hydroxymethyltransferase, cytosolic Trimethyllysine dioxygenase, mitochondrial	O75936 P34896 P49189 Q9NVH6	ALDH4 ALDH7 ALDH9 ALDH9A1 BBH BBOX BBOX1 SHMT1 TMLH TMLHE	Homo sapiens (human)
Proline catabolism	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial Hydroxyproline dehydrogenase Proline dehydrogenase 1, mitochondrial	O43272 P30038 Q9UF12	ALDH4 ALDH4A1 HSPOX1 HYPDH P5CDH PIG6 POX2 PRODH PRODH2	Homo sapiens (human)
Metabolism of serotonin	Aldehyde dehydrogenase, mitochondrial Amine oxidase [flavin-containing] A	P05091 P21397	ALDH2 ALDM MAOA	Homo sapiens (human)
Metabolism of folate and pterines	5-formyltetrahydrofolate cyclo-ligase Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial C-1-tetrahydrofolate synthase, cytoplasmic Cytosolic 10-formyltetrahydrofolate dehydrogenase Dihydrofolate reductase 2, mitochondrial Dihydrofolate reductase Folate receptor beta Methylenetetrahydrofolate reductase (NADPH) Mitochondrial 10-formyltetrahydrofolate dehydrogenase Monofunctional C1-tetrahydrofolate synthase, mitochondrial Proton-coupled folate transporter Reduced folate transporter Serine hydroxymethyltransferase, cytosolic Serine hydroxymethyltransferase, mitochondrial Solute carrier family 25 member 32	O75891 P00374 P11586 P13995 P14207 P34896 P34897 P41440 P42898 P49914 Q3SY69 Q6UB35 Q86XF0 Q96NT5 Q9H2D1 Q9H903	ALDH1L1 ALDH1L2 DHFR DHFR2 DHFRL1 DHFRP4 FLOT1 FOLR2 FTHFD FTHFSDC1 G21 HCP1 MFT MFTC MTHFC MTHFD MTHFD1 MTHFD1L MTHFD2 MTHFD2L MTHFR MTHFS NMDMC PCFT RFC1 SHMT1 SHMT2 SLC19A1 SLC25A32 SLC46A1	Homo sapiens (human)
RND2 GTPase cycle	Aldehyde dehydrogenase family 3 member A2 Ankyrin repeat domain-containing protein 26 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 Bridge-like lipid transfer protein family member 3B Caveolin-1 Cytoskeleton-associated protein 4 DEP domain-containing protein 1B Desmoglein-1 Disks large homolog 5 Dystonin Ephrin type-A receptor 2 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Formin-binding protein 1 Golgin subfamily A member 3 Inactive tyrosine-protein kinase PRAG1 Inner nuclear membrane protein Man1 Kinase D-interacting substrate of 220 kDa Kinectin Kinesin-like protein KIF14 Leucine-rich repeat-containing protein 1 Mucin-13 Nischarin Nuclear migration protein nudC Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Plakophilin-4 Plexin-D1 Protein FAM83B Protein scribble homolog RNA-binding motif protein, X chromosome Rho GTPase-activating protein 1 Rho GTPase-activating protein 35 Rho GTPase-activating protein 5 Rho-related GTP-binding protein RhoN Thioredoxin-like protein 1 Transferrin receptor protein 1 Tyrosine-protein phosphatase non-receptor type 13 UBX domain-containing protein 11 Vang-like protein 1 Vang-like protein 2 tRNA (34-2'-O)-methyltransferase regulator WDR6	A0JNW5 O00459 O43396 O43559 P02786 P27986 P29317 P38159 P51648 P52198 Q02413 Q03001 Q03135 Q07065 Q07960 Q08378 Q12923 Q13017 Q13829 Q14160 Q15058 Q5T0W9 Q5T124 Q86UP2 Q86YV5 Q8TAA9 Q8TDM6 Q8WU20 Q8WUY9 Q8WZ19 Q96RU3 Q99569 Q9BTT6 Q9H3R2 Q9NNW5 Q9NRY4 Q9ULH0 Q9ULK5 Q9UPS8 Q9Y266 Q9Y2I1 Q9Y2U8 Q9Y4D7	ALDH10 ALDH3A2 ANKRD26 ARHGAP1 ARHGAP35 ARHGAP5 ARHN ARMS BACURD1 BACURD2 BLTP3B BP230 BP240 BPAG1 C6orf143 CAV CAV1 CDC42GAP CDHF4 CG1 CKAP4 CRIB1 DEPDC1B DLG5 DMH DRCC1 DSG1 DST DT ECK EDP1 EPHA2 FALDH FAM83B FBP17 FNBP1 FRS2 FRS3 GOLGA3 GRB1 GRF1 GRLF1 HNRPG IRAS KCTD13 KIAA0004 KIAA0042 KIAA0147 KIAA0554 KIAA0583 KIAA0620 KIAA0701 KIAA0728 KIAA0975 KIAA1074 KIAA1215 KIAA1250 KIAA1722 KIDINS220 KIF14 KTN1 LANO LAP4 LEMD3 LRRC1 MAN1 MUC13 NISCH NUDC P190A PDIP1 PDLG PIK3R1 PIK3R2 PKP4 PLXND1 PNP1 POLDIP1 PRAG1 PTP1E PTPL1 PTPN13 RBMX RBMXP1 RECC RHO7 RHOGAP1 RHOGAP5 RND2 SCRB1 SCRIB SGK223 SHIP164 SOC STB1 STB2 TFRC TNFAIP1 TRP32 TXL TXNL TXNL1 UBXD5 UBXN11 UHRF1BP1L VANGL1 VANGL2 VARTUL WDR6 XTP8 p190ARHOGAP	Homo sapiens (human)
RND1 GTPase cycle	Aldehyde dehydrogenase family 3 member A2 Ankyrin repeat domain-containing protein 26 Carboxypeptidase D Caveolin-1 DEP domain-containing protein 1B Desmoplakin Disks large homolog 5 Dystonin Ephrin type-A receptor 2 Epithelial-stromal interaction protein 1 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Flotillin-2 Girdin Growth factor receptor-bound protein 7 Inner nuclear membrane protein Man1 Kinase D-interacting substrate of 220 kDa Kinesin-like protein KIF14 Mucin-13 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Plakophilin-4 Pleckstrin homology domain-containing family G member 5 Plexin-A1 Protein FAM135A Protein FAM83B RNA-binding motif protein, X chromosome Ras GTPase-activating protein nGAP Ras-related protein R-Ras2 Rho GTPase-activating protein 35 Rho GTPase-activating protein 5 Rho-related GTP-binding protein Rho6 Stathmin-2 Stress-induced-phosphoprotein 1 Thioredoxin-like protein 1 Transferrin receptor protein 1 Transmembrane protein 59 Tyrosine-protein phosphatase non-receptor type 13 UBX domain-containing protein 11 Vang-like protein 1 Vang-like protein 2 tRNA (34-2'-O)-methyltransferase regulator WDR6	O00459 O43396 O43559 O75976 O94827 P02786 P15924 P27986 P29317 P31948 P38159 P51648 P62070 Q03001 Q03135 Q12923 Q13017 Q14254 Q14451 Q15058 Q3V6T2 Q5T0W9 Q5T124 Q8TAA9 Q8TDM6 Q8WU20 Q8WUY9 Q92730 Q93045 Q96J88 Q99569 Q9BXS4 Q9H3R2 Q9NNW5 Q9NRY4 Q9P2D6 Q9UIW2 Q9UJF2 Q9ULH0 Q9ULK5 Q9UPS8 Q9Y2U8	ALDH10 ALDH3A2 ANKRD26 APE ARHGAP35 ARHGAP5 ARMS BP230 BP240 BPAG1 C1orf8 C6orf143 CAV CAV1 CCDC88A CPD DEPDC1B DLG5 DMH DRCC1 DSP DST DT ECK EPHA2 EPSTI1 ESA1 FALDH FAM135A FAM83B FLOT2 FRS2 FRS3 GRB1 GRB7 GRDN GRF1 GRLF1 HNRPG KIAA0042 KIAA0583 KIAA0720 KIAA0728 KIAA1074 KIAA1212 KIAA1215 KIAA1250 KIAA1411 KIAA1722 KIDINS220 KIF14 LEMD3 M17S1 MAN1 MUC13 NGAP NOV P190A PDLG PIK3R1 PIK3R2 PKP4 PLEKHG5 PLXN1 PLXNA1 PNP1 PTP1E PTPL1 PTPN13 RASAL2 RBMX RBMXP1 RECC RHO6 RHOGAP5 RND1 RRAS2 SCG10 SCGN10 SOC STB1 STB2 STIP1 STMN2 TC21 TFRC TMEM59 TRP32 TXL TXNL TXNL1 UBXD5 UBXN11 VANGL1 VANGL2 WDR6 XTP8 p190ARHOGAP	Homo sapiens (human)
Hereditary fructose intolerance	Fructose-bisphosphate aldolase B	P05062	ALDB ALDOB	Homo sapiens (human)
Fructose catabolism	Aldehyde dehydrogenase 1A1 Fructose-bisphosphate aldolase B Glycerate kinase Ketohexokinase Triokinase/FMN cyclase	P00352 P05062 P50053 Q3LXA3 Q8IVS8	ALDB ALDC ALDH1 ALDH1A1 ALDOB DAK GLYCTK HBEBP4 KHK PUMB1 TKFC	Homo sapiens (human)
Gluconeogenesis	Alpha-enolase Beta-enolase Enolase 4 Fructose-1,6-bisphosphatase 1 Fructose-1,6-bisphosphatase isozyme 2 Fructose-bisphosphate aldolase A Fructose-bisphosphate aldolase B Fructose-bisphosphate aldolase C Gamma-enolase Glucose-6-phosphatase 2 Glucose-6-phosphatase 3 Glucose-6-phosphatase catalytic subunit 1 Glucose-6-phosphate exchanger SLC37A1 Glucose-6-phosphate exchanger SLC37A4 Glucose-6-phosphate isomerase Glyceraldehyde-3-phosphate dehydrogenase, testis-specific Glyceraldehyde-3-phosphate dehydrogenase Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Phosphoenolpyruvate carboxykinase, cytosolic [GTP] Phosphoglycerate kinase 1 Phosphoglycerate kinase 2 Phosphoglycerate mutase 1 Phosphoglycerate mutase 2 Pyruvate carboxylase, mitochondrial Triosephosphate isomerase	A6NNW6 O00757 O14556 O43826 P00558 P04075 P04406 P05062 P06733 P06744 P07205 P09104 P09467 P09972 P11498 P13929 P15259 P18669 P35558 P35575 P57057 P60174 Q16822 Q9BUM1 Q9NQR9	ALDA ALDB ALDC ALDOA ALDOB ALDOC C10orf134 ENO1 ENO1L1 ENO2 ENO3 ENO4 FBP FBP1 FBP2 G3PP G6PC G6PC1 G6PC2 G6PC3 G6PT G6PT1 GAPD GAPD2 GAPDH GAPDH2 GAPDHS GAPDS GPI IGRP MBPB1 MPB1 PC PCK1 PCK2 PEPCK1 PEPCK2 PGAM1 PGAM2 PGAMA PGAMM PGK1 PGK2 PGKA PGKB SLC37A1 SLC37A4 TPI TPI1 UGRP	Homo sapiens (human)	G58161NS
L1CAM interactions	Acyl-protein thioesterase 2 CD166 antigen Contactin-1 Contactin-2 Ephrin type-B receptor 2 Laminin subunit alpha-1 Laminin subunit beta-1 Laminin subunit gamma-1 Neural cell adhesion molecule L1 Neurocan core protein Neuromodulin Ran-binding protein 9 Signal transducer CD24	O14594 O95372 P07942 P11047 P17677 P25063 P25391 P29323 P32004 Q02246 Q12860 Q13740 Q96S59	ALCAM APT2 AXT CAML1 CD24 CD24A CNTN1 CNTN2 CSPG3 DRT EPHB2 EPHT3 EPTH3 ERK GAP43 HEK5 L1CAM LAMA LAMA1 LAMB1 LAMB2 LAMC1 LYPLA2 MEMD MIC5 NCAN NEUR RANBP9 RANBPM TAG1 TAX1 TYRO5	Homo sapiens (human)
PDE3B signalling	RAC-beta serine/threonine-protein kinase cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	P31751 Q13370	AKT2 PDE3B	Homo sapiens (human)
Inhibition of TSC complex formation by PKB	Hamartin RAC-beta serine/threonine-protein kinase Tuberin	P31751 P49815 Q92574	AKT2 KIAA0243 TSC TSC1 TSC2 TSC4	Homo sapiens (human)
Activation of PKB	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 RAC-beta serine/threonine-protein kinase Tribbles homolog 3	O15530 P31751 Q5T1C6 Q96RU7	AKT2 C20orf97 CTMP NIPK PDK1 PDPK1 SKIP3 THEM4 TRB3 TRIB3	Homo sapiens (human)
HSF1-dependent transactivation	Alpha-crystallin B chain Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma DnaJ homolog subfamily B member 1 Heat shock 70 kDa protein 1-like Heat shock 70 kDa protein 1A Heat shock 70 kDa protein 1B Heat shock cognate 71 kDa protein Heat shock factor protein 1 Heat shock factor-binding protein 1 Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Heat shock protein beta-8 Proline-rich AKT1 substrate 1 Regulatory-associated protein of mTOR Serine/threonine-protein kinase mTOR Target of rapamycin complex subunit LST8	O75506 P02511 P07900 P08238 P0DMV8 P0DMV9 P11142 P25685 P34931 P42345 Q00613 Q13554 Q13555 Q13557 Q8N122 Q96B36 Q9BVC4 Q9UJY1 Q9UQM7	AKT1S1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CRYA2 CRYAB CRYAC DNAJ1 DNAJB1 E2IG1 FRAP FRAP1 FRAP2 GBL HDJ1 HSBP1 HSC70 HSF1 HSF1BP HSP22 HSP72 HSP73 HSP90A HSP90AA1 HSP90AB1 HSP90B HSPA1 HSPA10 HSPA1A HSPA1B HSPA1L HSPA8 HSPB5 HSPB8 HSPC1 HSPC2 HSPC3 HSPCA HSPCB HSPF1 HSTF1 HSX70 KIAA0968 KIAA1303 LST8 MLST8 MTOR PRAS40 RAFT1 RAPT1 RAPTOR RPTOR	Homo sapiens (human)
mTORC1-mediated signalling	14-3-3 protein beta/alpha Eukaryotic elongation factor 2 kinase Eukaryotic translation initiation factor 4 gamma 1 Eukaryotic translation initiation factor 4B Eukaryotic translation initiation factor 4E-binding protein 1 Eukaryotic translation initiation factor 4E GTP-binding protein Rheb Neutral amino acid transporter 9 Peptidyl-prolyl cis-trans isomerase FKBP1A Proline-rich AKT1 substrate 1 Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Ribosomal protein S6 kinase beta-1 Serine/threonine-protein kinase mTOR Small ribosomal subunit protein eS6 Target of rapamycin complex subunit LST8	O00418 O43504 P06730 P23443 P23588 P31946 P42345 P62753 P62942 Q04637 Q0VGL1 Q13541 Q15382 Q5VZM2 Q6IAA8 Q7L523 Q8N122 Q8NBW4 Q96B36 Q9BVC4 Q9HB90 Q9NQL2 Q9UHA4 Q9Y2Q5	AKT1S1 C11orf59 C7orf59 EEF2K EIF4B EIF4E EIF4EBP1 EIF4EL1 EIF4F EIF4G EIF4G1 EIF4GI FKBP1 FKBP12 FKBP1A FRAP FRAP1 FRAP2 GBL HBXIP KIAA1303 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MTOR PDRO PRAS40 RAFT1 RAPT1 RAPTOR RHEB RHEB2 ROBLD3 RPS6 RPS6KB1 RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 STK14A URLC11 XIP YWHAB	Homo sapiens (human)
KSRP (KHSRP) binds and destabilizes mRNA	14-3-3 protein zeta/delta Exosome complex component CSL4 Exosome complex component MTR3 Exosome complex component RRP40 Exosome complex component RRP41 Exosome complex component RRP42 Exosome complex component RRP43 Exosome complex component RRP45 Exosome complex component RRP46 Exosome complex component RRP4 Exosome complex exonuclease RRP44 Far upstream element-binding protein 2 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Poly(A)-specific ribonuclease PARN RAC-alpha serine/threonine-protein kinase m7GpppN-mRNA hydrolase	O95453 P31749 P63104 Q06265 Q13868 Q15024 Q15759 Q16539 Q5RKV6 Q8IU60 Q92945 Q96B26 Q9NPD3 Q9NQT4 Q9NQT5 Q9Y2L1 Q9Y3B2	AKT1 CML28 CSBP CSBP1 CSBP2 CSL4 CSPB1 DAN DCP2 DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FUBP2 KHSRP KIAA0116 KIAA1008 MAPK11 MAPK14 MTR3 MXI2 NUDT20 OIP2 PARN PKB PMSCL1 PRKM11 RAC RRP4 RRP40 RRP41 RRP42 RRP43 RRP44 RRP46 SAPK2 SAPK2A SAPK2B SKI6 YWHAZ	Homo sapiens (human)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	6-pyruvoyl tetrahydrobiopterin synthase Calmodulin-1 Dihydrofolate reductase GTP cyclohydrolase 1 feedback regulatory protein GTP cyclohydrolase 1 Heat shock protein HSP 90-alpha Nitric oxide synthase 3 RAC-alpha serine/threonine-protein kinase Sepiapterin reductase cGMP-dependent protein kinase 2	P00374 P07900 P0DP23 P29474 P30047 P30793 P31749 P35270 Q03393 Q13237	AKT1 CALM CALM1 CAM CAM1 DHFR DYT5 GCH GCH1 GCHFR GFRP HSP90A HSP90AA1 HSPC1 HSPCA NOS3 PKB PRKG2 PRKGR2 PTS RAC SPR	Homo sapiens (human)
Negative regulation of NOTCH4 signaling	14-3-3 protein zeta/delta 26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin-1 E3 ubiquitin-protein ligase RBX1 Neurogenic locus notch homolog protein 4 Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-10 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 RAC-alpha serine/threonine-protein kinase S-phase kinase-associated protein 1 Transforming acidic coiled-coil-containing protein 3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00231 O00232 O00233 O00487 O14818 O43242 O75832 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P31749 P35998 P40306 P43686 P48556 P49720 P49721 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 P62877 P62979 P62987 P63104 P63208 Q06323 Q13200 Q13616 Q15008 Q16401 Q92530 Q99436 Q99460 Q99466 Q9UL46 Q9UNM6 Q9Y6A5	AKT1 C7orf76 CUL1 DSS1 EMC19 ERIC1 HC2 HC3 HC8 HC9 HSPC IFI5111 INT3 KIAA0072 KIAA0107 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NOTCH4 NU OCP2 PFAAP4 PKB POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSMF1 RAC RBX1 RING10 RING12 RNF75 ROC1 RPS27A SEM1 SHFDG1 SHFM1 SKP1 SKP1A SUG1 SUG2 TACC3 TBP1 TBP7 TCEB1L TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 X Y Y2 YWHAZ Z	Homo sapiens (human)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	14-3-3 protein beta/alpha 5'-3' exoribonuclease 1 Exosome complex component CSL4 Exosome complex component MTR3 Exosome complex component RRP40 Exosome complex component RRP41 Exosome complex component RRP42 Exosome complex component RRP43 Exosome complex component RRP45 Exosome complex component RRP46 Exosome complex component RRP4 Exosome complex exonuclease RRP44 MAP kinase-activated protein kinase 2 RAC-alpha serine/threonine-protein kinase m7GpppN-mRNA hydrolase mRNA decay activator protein ZFP36L1 mRNA-decapping enzyme 1A	P31749 P31946 P49137 Q06265 Q07352 Q13868 Q15024 Q5RKV6 Q8IU60 Q8IZH2 Q96B26 Q9NPD3 Q9NPI6 Q9NQT4 Q9NQT5 Q9Y2L1 Q9Y3B2	AKT1 BERG36 BRF1 CML28 CSL4 DCP1A DCP2 DIS3 ERF1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 KIAA0116 KIAA1008 MAPKAPK2 MTR3 NUDT20 OIP2 PKB PMSCL1 RAC RNF162B RRP4 RRP40 RRP41 RRP42 RRP43 RRP44 RRP46 SEP1 SKI6 SMIF TIS11B XRN1 YWHAB ZFP36L1	Homo sapiens (human)
Extra-nuclear estrogen signaling	72 kDa type IV collagenase Amphiregulin Calmodulin-1 Caveolin-1 Caveolin-2 Epidermal growth factor receptor Epigen Estrogen receptor beta Estrogen receptor Focal adhesion kinase 1 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(i) subunit alpha-1 Guanine nucleotide-binding protein G(i) subunit alpha-2 Guanine nucleotide-binding protein G(i) subunit alpha-3 Guanine nucleotide-binding protein G(t) subunit alpha-3 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Heat shock protein HSP 90-alpha Insulin-like growth factor 1 receptor Matrilysin Matrix metalloproteinase-9 Nitric oxide synthase 3 Palmitoyltransferase ZDHHC21 Palmitoyltransferase ZDHHC7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein arginine N-methyltransferase 1 Proto-oncogene tyrosine-protein kinase Src Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase Sphingosine 1-phosphate receptor 3 Sphingosine kinase 1 Striatin Stromelysin-1	A8MTJ3 O00459 O14610 O14775 O14944 O43815 O60262 P00533 P01133 P01135 P03372 P04899 P07900 P08069 P08253 P08254 P08754 P09237 P0DP23 P12931 P14780 P15514 P16520 P27986 P29474 P31749 P35070 P42336 P50150 P50151 P51636 P59768 P61952 P62873 P62879 P63096 P63211 P63215 P63218 Q03135 Q05397 Q6UW88 Q8IVQ6 Q92569 Q92731 Q99075 Q99500 Q99873 Q9HAV0 Q9NXF8 Q9NYA1 Q9P2W3 Q9UBI6 Q9UK08	AKT1 AREG AREGB BTC C9orf108 C9orf47 CALM CALM1 CAM CAM1 CAV CAV1 CAV2 CLG4A CLG4B DTR DTS EDG3 EGF EGFR EPGN ERBB ERBB1 EREG ESR ESR1 ESR2 ESTRB FAK FAK1 GNAI1 GNAI2 GNAI2B GNAI3 GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 GRB1 HBEGF HEGFL HER1 HMT2 HRMT1L2 HSP90A HSP90AA1 HSPC1 HSPCA IGF1R IR1B4 MMP2 MMP3 MMP7 MMP9 MPSL1 NOS3 NR3A1 NR3A2 PIK3CA PIK3R1 PIK3R2 PIK3R3 PKB PRMT1 PTK2 PUMP1 RAC S1PR3 SDGF SK1 SPHK SPHK1 SPK SRC SRC1 STMY1 STRN TGFA ZDHHC21 ZDHHC7	Homo sapiens (human)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Amphiregulin B-lymphocyte antigen CD19 Beta-klotho Epidermal growth factor receptor Epigen Estrogen receptor beta Estrogen receptor Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Insulin receptor Insulin Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-like 1 Interleukin-33 Mast/stem cell growth factor receptor Kit Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Myeloid differentiation primary response protein MyD88 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Phosphatidylinositol 4-phosphate 5-kinase type-1 beta Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Phosphoinositide 3-kinase adapter protein 1 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Proto-oncogene vav Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase Radiation-inducible immediate-early gene IEX-1 Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Receptor tyrosine-protein kinase erbB-2 Receptor-type tyrosine-protein kinase FLT3 Rho-related GTP-binding protein RhoG Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Striatin T-cell receptor-associated transmembrane adapter 1 T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 TNF receptor-associated factor 6 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein phosphatase non-receptor type 11	O00329 O00459 O14511 O14944 O14986 O15520 O43320 O43815 O60331 O76093 O95750 O95760 P00533 P01127 P01133 P01135 P01308 P03372 P04626 P05230 P06213 P06239 P06241 P08581 P08620 P09038 P09619 P10721 P10747 P10767 P11487 P12931 P14210 P15153 P15391 P15498 P15514 P16234 P21781 P22455 P27361 P27986 P28482 P30153 P30154 P31371 P31749 P33681 P35070 P35568 P36888 P42081 P42336 P42338 P46695 P48426 P49771 P51617 P56975 P62714 P63000 P67775 P78356 P84095 Q01638 Q02297 Q06124 Q13362 Q13480 Q14738 Q15172 Q15173 Q16537 Q6PIZ9 Q6UW88 Q6ZUJ8 Q86Z14 Q8TBX8 Q8WU20 Q8WWG1 Q92569 Q92731 Q99075 Q99755 Q99836 Q9GZV9 Q9HCT0 Q9NP95 Q9NWZ3 Q9UQC2 Q9Y4H2 Q9Y4K3	AKT1 AREG AREGB ARHG BCAP BTC C9orf26 CD135 CD19 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 DER4 DIF2 DTR DTS EGF EGFR EPGN ERBB ERBB1 ERBB2 EREG ERK1 ERK2 ESR ESR1 ESR2 ESTRB FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 FYN GAB1 GAB2 GGF GRB1 HBEGF HEGFL HER1 HER2 HGF HGL HPTA HRGA HST HST2 HSTF1 HSTF2 HYPF IER3 IEX1 IL1F11 IL1RL1 IL33 INS INSR INT2 IRAK IRAK1 IRAK4 IRS1 IRS2 JTK2 KGF KIAA0044 KIAA0571 KIAA0589 KIT KLB KS3 LAB7 LCK MAPK1 MAPK3 MET MLN19 MYD88 NDF NEU NFHEV NGL NR3A1 NR3A2 NRG1 NRG2 NRG3 NRG4 NTAK PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PI5P4KA PIK3AP1 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PIP5K2 PIP5K2A PIP5K2B PIP5K2C PKB PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRG1 PRKM1 PRKM2 PRKM3 PTP2C PTPN11 RAC RAC1 RAC2 RHEPDGFRA RHOG RNF85 SCFR SDGF SHPTP2 SIS SMDF SRC SRC1 ST2 STK1 STM7 STRN T1 TC25 TCRIM TGFA TKF TRAF6 TRAT1 VAV VAV1	Homo sapiens (human)

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