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slit1 slit guidance ligand 1 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100036682, updated on 9-Dec-2024

Summary

Official Symbol
slit1provided by Xenbase
Official Full Name
slit guidance ligand 1provided by Xenbase
Primary source
Xenbase:XB-GENE-1007728
See related
Ensembl:ENSXETG00000003405 AllianceGenome:Xenbase:XB-GENE-1007728
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
Xslit; megf4; slil1; slit3; slit-1
Summary
Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in axon guidance and negative chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human SLIT1 (slit guidance ligand 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See slit1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
37
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 7 NC_030683.2 (32334015..32553718, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 7 NC_030683.1 (24005256..24225376, complement)

Chromosome 7 - NC_030683.2Genomic Context describing neighboring genes Neighboring gene peroxisome proliferator-activated receptor gamma, coactivator-related 1 Neighboring gene ligand dependent nuclear receptor corepressor Neighboring gene uncharacterized LOC105948021 Neighboring gene Rho GTPase activating protein 19 Neighboring gene neurotensin receptor type 1-like

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables Roundabout binding  
enables calcium ion binding  
enables heparin binding  
enables signaling receptor binding  
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ development  
involved_in axon guidance  
acts_upstream_of_or_within axon guidance  
acts_upstream_of_or_within cell differentiation  
involved_in negative chemotaxis  
acts_upstream_of_or_within negative chemotaxis  
acts_upstream_of_or_within nervous system development  
Component Evidence Code Pubs
located_in extracellular region  
is_active_in extracellular space  

General protein information

Preferred Names
slit homolog 1 protein
Names
slit homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097233.1NP_001090702.1  slit homolog 1 protein precursor

    See identical proteins and their annotated locations for NP_001090702.1

    Status: PROVISIONAL

    Source sequence(s)
    BC135997
    UniProtKB/TrEMBL
    A0A6I8RSE7, A1A5F4, F6VMC0
    Related
    ENSXETP00000007398.3, ENSXETT00000007398.5
    Conserved Domains (10) summary
    TIGR00864
    Location:841978
    PCC; polycystin cation channel protein
    smart00013
    Location:3263
    LRRNT; Leucine rich repeat N-terminal domain
    smart00282
    Location:11841317
    LamG; Laminin G domain
    COG4886
    Location:70218
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00054
    Location:10831117
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00033
    Location:6285
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00008
    Location:11261155
    EGF; EGF-like domain
    pfam13855
    Location:785843
    LRR_8; Leucine rich repeat
    NF033189
    Location:531865
    internalin_A; class 1 internalin InlA
    cl15307
    Location:214263
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030683.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    32334015..32553718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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