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AARS1 alanyl-tRNA synthetase 1 [ Pongo abelii (Sumatran orangutan) ]

Gene ID: 100172296, updated on 3-Dec-2024

Summary

Gene symbol
AARS1
Gene description
alanyl-tRNA synthetase 1
Locus tag
CR201_G0015351
See related
Ensembl:ENSPPYG00000007544
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pongo abelii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs
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Genomic context

See AARS1 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 18 NC_072003.2 (73559354..73594597)
RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 16 NC_072001.1 (72972534..73007763)

Chromosome 18 - NC_072003.2Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 19A Neighboring gene uncharacterized LOC134760434 Neighboring gene ATP-dependent RNA helicase DDX19B Neighboring gene exosome component 6 Neighboring gene C-type lectin domain family 18 member A Neighboring gene uncharacterized LOC134760433

Genomic regions, transcripts, and products

General gene information

Clone Names

  • DKFZp459G207

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding PubMed 
enables alanine-tRNA ligase activity PubMed 
enables aminoacyl-tRNA editing activity PubMed 
enables nucleic acid binding PubMed 
Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in mitochondrion PubMed 

General protein information

Preferred Names
alanine--tRNA ligase, cytoplasmic
Names
AARS
Alanyl-tRNA synthetase, cytoplasmic
alaRS
protein lactyltransferase AARS1
NP_001125391.1
XP_024088780.1
XP_063573130.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131919.1NP_001125391.1  alanine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_001125391.1

    Status: PROVISIONAL

    Source sequence(s)
    CR858480
    UniProtKB/Swiss-Prot
    Q5RC02
    UniProtKB/TrEMBL
    A0A8I5U7E4
    Related
    ENSPPYP00000008517.3, ENSPPYT00000008865.3
    Conserved Domains (6) summary
    PLN02900
    Location:6961
    PLN02900; alanyl-tRNA synthetase
    cd00673
    Location:7254
    AlaRS_core; Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    pfam02272
    Location:886955
    DHHA1; DHHA1 domain
    cl02787
    Location:495531
    Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins
    cl08469
    Location:525753
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cl21456
    Location:767809
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

  1. NC_072003.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Range
    73559354..73594597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024233012.3XP_024088780.1  alanine--tRNA ligase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A2J8VW82, A0A8I5U7E4, H2NRG6
    Conserved Domains (1) summary
    PLN02900
    Location:6961
    PLN02900; alanyl-tRNA synthetase
  2. XM_063717060.1XP_063573130.1  alanine--tRNA ligase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A2J8VW82, A0A8I5U7E4, H2NRG6
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