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ptena phosphatase and tensin homolog A [ Oreochromis niloticus (Nile tilapia) ]

Gene ID: 100695712, updated on 8-Mar-2024

Summary

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Gene symbol
ptena
Gene description
phosphatase and tensin homolog A
See related
Ensembl:ENSONIG00000000386
Gene type
protein coding
RefSeq status
MODEL
Organism
Oreochromis niloticus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; Pseudocrenilabrinae; Oreochromini; Oreochromis
Orthologs
zebrafish all
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Genomic context

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See ptena in Genome Data Viewer
Location:
chromosome: LG13
Exon count:
10
Annotation release Status Assembly LG Location
104 current O_niloticus_UMD_NMBU (GCF_001858045.2) LG13 NC_031978.2 (14883484..14894815, complement)
103 previous assembly ASM185804v2 (GCF_001858045.1) LG13 NC_031978.1 (714267..725502)

Linkage Group LG13 - NC_031978.2Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily member 6 Neighboring gene uncharacterized LOC102083077 Neighboring gene bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Neighboring gene multiple inositol polyphosphate phosphatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity PubMed 
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity PubMed 
enables protein tyrosine phosphatase activity PubMed 
Process Evidence Code Pubs
involved_in cell motility PubMed 
involved_in negative regulation of cell population proliferation PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in phosphatidylinositol dephosphorylation PubMed 
involved_in protein dephosphorylation PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
Component Evidence Code Pubs
located_in cell projection PubMed 
located_in cytosol PubMed 
located_in nucleus PubMed 
located_in plasma membrane PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Oreochromis niloticus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference O_niloticus_UMD_NMBU Primary Assembly

Genomic

  1. NC_031978.2 Reference O_niloticus_UMD_NMBU Primary Assembly

    Range
    14883484..14894815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005474213.4 → XP_005474270.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2

    UniProtKB/TrEMBL
    A0A669D261, I3IV48
    Related
    ENSONIP00000000488.2, ENSONIT00000000487.2
    Conserved Domains (2) summary
    cd14509
    Location:24 → 181
    PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog
    pfam10409
    Location:188 → 388
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

  2. XM_005474212.4 → XP_005474269.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1

    See identical proteins and their annotated locations for XP_005474269.1

    UniProtKB/TrEMBL
    A0A669D261, I3IV47
    Related
    ENSONIP00000000487.1, ENSONIT00000000486.2
    Conserved Domains (2) summary
    cd14509
    Location:24 → 181
    PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog
    pfam10409
    Location:188 → 411
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

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