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Epb41 erythrocyte membrane protein band 4.1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313052, updated on 4-Jan-2025

Summary

Official Symbol
Epb41provided by RGD
Official Full Name
erythrocyte membrane protein band 4.1provided by RGD
Primary source
RGD:1564762
See related
EnsemblRapid:ENSRNOG00000010037 AllianceGenome:RGD:1564762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Epb4.1; RGD1564762
Summary
Enables actin binding activity and spectrin binding activity. Involved in protein-containing complex assembly. Located in cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in hereditary elliptocytosis. Orthologous to human EPB41 (erythrocyte membrane protein band 4.1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 422.3), Kidney (RPKM 205.5) and 8 other tissues See more
Orthologs
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Genomic context

See Epb41 in Genome Data Viewer
Location:
5q36
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149394080..149548178, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144110010..144264037, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150081727..150243186, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene serine and arginine rich splicing factor 4 Neighboring gene transmembrane protein 200B Neighboring gene opioid receptor, delta 1 Neighboring gene YTH N6-methyladenosine RNA binding protein F2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding  
enables actin binding PubMed 
enables calmodulin binding  
enables phosphoprotein binding  
enables protein binding PubMed 
enables spectrin binding PubMed 
enables structural constituent of cytoskeleton  
Component Evidence Code Pubs
located_in basolateral plasma membrane  
located_in cell cortex  
located_in cell junction  
located_in cell junction  
located_in cortical cytoskeleton  
located_in cytoplasmic side of plasma membrane PubMed 
is_active_in cytoskeleton  
located_in cytosol  
located_in cytosol  
located_in intercellular bridge  
located_in intercellular bridge  
located_in membrane  
located_in mitotic spindle  
located_in mitotic spindle  
located_in nuclear body  
located_in nuclear body  
located_in nucleus  
is_active_in plasma membrane  
located_in plasma membrane  
part_of protein-containing complex  

General protein information

Preferred Names
protein 4.1
Names
erythrocyte protein band 4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399558.1NP_001386487.1  protein 4.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4A9A6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    149394080..149548178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287563.1XP_063143633.1  protein 4.1 isoform X40

    UniProtKB/TrEMBL
    A0A0G2KAK2
  2. XM_063287556.1XP_063143626.1  protein 4.1 isoform X33

    UniProtKB/TrEMBL
    A0A0G2KAK2
  3. XM_063287555.1XP_063143625.1  protein 4.1 isoform X32

  4. XM_063287546.1XP_063143616.1  protein 4.1 isoform X22

  5. XM_063287551.1XP_063143621.1  protein 4.1 isoform X28

  6. XM_063287548.1XP_063143618.1  protein 4.1 isoform X25

  7. XM_063287554.1XP_063143624.1  protein 4.1 isoform X31

  8. XM_063287549.1XP_063143619.1  protein 4.1 isoform X26

  9. XM_063287550.1XP_063143620.1  protein 4.1 isoform X27

  10. XM_063287552.1XP_063143622.1  protein 4.1 isoform X29

  11. XM_063287567.1XP_063143637.1  protein 4.1 isoform X44

    UniProtKB/TrEMBL
    A0A0G2KAK2
  12. XM_063287562.1XP_063143632.1  protein 4.1 isoform X39

    UniProtKB/TrEMBL
    A0A0G2KAK2
  13. XM_063287558.1XP_063143628.1  protein 4.1 isoform X35

    UniProtKB/TrEMBL
    A0A0G2KAK2
  14. XM_063287568.1XP_063143638.1  protein 4.1 isoform X45

    UniProtKB/TrEMBL
    A0A0G2KAK2
  15. XM_063287565.1XP_063143635.1  protein 4.1 isoform X42

    UniProtKB/TrEMBL
    A0A0G2KAK2
  16. XM_063287573.1XP_063143643.1  protein 4.1 isoform X50

    UniProtKB/TrEMBL
    A0A0G2KAK2
  17. XM_063287566.1XP_063143636.1  protein 4.1 isoform X43

    UniProtKB/TrEMBL
    A0A0G2KAK2
  18. XM_063287560.1XP_063143630.1  protein 4.1 isoform X37

    UniProtKB/TrEMBL
    A0A0G2KAK2
  19. XM_063287570.1XP_063143640.1  protein 4.1 isoform X47

    UniProtKB/TrEMBL
    A0A0G2KAK2
  20. XM_063287572.1XP_063143642.1  protein 4.1 isoform X49

    UniProtKB/TrEMBL
    A0A0G2KAK2
  21. XM_063287557.1XP_063143627.1  protein 4.1 isoform X34

    UniProtKB/TrEMBL
    A0A0G2KAK2
  22. XM_063287571.1XP_063143641.1  protein 4.1 isoform X48

    UniProtKB/TrEMBL
    A0A0G2KAK2
  23. XM_063287561.1XP_063143631.1  protein 4.1 isoform X38

    UniProtKB/TrEMBL
    A0A0G2KAK2
  24. XM_063287564.1XP_063143634.1  protein 4.1 isoform X41

    UniProtKB/TrEMBL
    A0A0G2KAK2
  25. XM_063287559.1XP_063143629.1  protein 4.1 isoform X36

    UniProtKB/TrEMBL
    A0A0G2KAK2
  26. XM_063287569.1XP_063143639.1  protein 4.1 isoform X46

    UniProtKB/TrEMBL
    A0A0G2KAK2
  27. XM_039111260.1XP_038967188.1  protein 4.1 isoform X17

    UniProtKB/TrEMBL
    D4A9A6
    Conserved Domains (5) summary
    smart00295
    Location:210400
    B41; Band 4.1 homologues
    cd13184
    Location:395488
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:605651
    SAB; SAB domain
    pfam05902
    Location:690796
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:498541
    FA; FERM adjacent (FA)
  28. XM_063287545.1XP_063143615.1  protein 4.1 isoform X19

    UniProtKB/TrEMBL
    A0A8I6A4E3
  29. XM_063287542.1XP_063143612.1  protein 4.1 isoform X10

    UniProtKB/TrEMBL
    D4A9A6
  30. XM_063287547.1XP_063143617.1  protein 4.1 isoform X24

    UniProtKB/TrEMBL
    A0A8I6A4E3
  31. XM_017593842.1XP_017449331.1  protein 4.1 isoform X16

    UniProtKB/TrEMBL
    D3ZKF7, D4A9A6
    Related
    ENSRNOP00000061387.2, ENSRNOT00000067349.6
  32. XM_063287544.1XP_063143614.1  protein 4.1 isoform X14

    UniProtKB/TrEMBL
    D4A9A6
  33. XM_063287543.1XP_063143613.1  protein 4.1 isoform X13

    UniProtKB/TrEMBL
    D4A9A6
  34. XM_017593843.1XP_017449332.1  protein 4.1 isoform X18

    UniProtKB/TrEMBL
    A0A8I6A4E3
  35. XM_063287540.1XP_063143610.1  protein 4.1 isoform X5

    UniProtKB/TrEMBL
    A6ISR5
  36. XM_063287539.1XP_063143609.1  protein 4.1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y1T6, A6ISR5
    Related
    ENSRNOP00000077988.1, ENSRNOT00000107222.2
  37. XM_017593838.1XP_017449327.1  protein 4.1 isoform X11

    UniProtKB/TrEMBL
    D4A9A6
  38. XM_063287538.1XP_063143608.1  protein 4.1 isoform X3

    UniProtKB/TrEMBL
    A6ISR5
  39. XM_039111259.1XP_038967187.1  protein 4.1 isoform X15

    UniProtKB/TrEMBL
    D4A9A6
    Conserved Domains (5) summary
    smart00295
    Location:210400
    B41; Band 4.1 homologues
    cd13184
    Location:395488
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:658706
    SAB; SAB domain
    pfam05902
    Location:720808
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:498541
    FA; FERM adjacent (FA)
  40. XM_017593839.1XP_017449328.1  protein 4.1 isoform X12

    UniProtKB/TrEMBL
    A0A8I6A4E3
    Related
    ENSRNOP00000085800.2, ENSRNOT00000112187.2
  41. XM_017593836.1XP_017449325.1  protein 4.1 isoform X9

    UniProtKB/TrEMBL
    D3ZIP3, D4A9A6
    Related
    ENSRNOP00000075428.3, ENSRNOT00000079935.3
  42. XM_017593830.1XP_017449319.1  protein 4.1 isoform X2

    UniProtKB/TrEMBL
    A6ISR5
  43. XM_017593835.1XP_017449324.1  protein 4.1 isoform X8

    UniProtKB/TrEMBL
    D4A9A6
    Related
    ENSRNOP00000013761.5, ENSRNOT00000013761.8
  44. XM_017593827.1XP_017449316.1  protein 4.1 isoform X1

    UniProtKB/TrEMBL
    A6ISR5
  45. XM_063287541.1XP_063143611.1  protein 4.1 isoform X6

    UniProtKB/TrEMBL
    D4A9A6
  46. XM_017593834.1XP_017449323.1  protein 4.1 isoform X7

    UniProtKB/TrEMBL
    D4A9A6
  47. XM_039111264.2XP_038967192.1  protein 4.1 isoform X21

    UniProtKB/TrEMBL
    A0A0G2K161
    Conserved Domains (4) summary
    smart00295
    Location:210400
    B41; Band 4.1 homologues
    cd13184
    Location:395488
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:657705
    SAB; SAB domain
    pfam08736
    Location:498541
    FA; FERM adjacent (FA)
  48. XM_063287553.1XP_063143623.1  protein 4.1 isoform X30

    UniProtKB/TrEMBL
    A0A0G2K161
  49. XM_039111265.2XP_038967193.1  protein 4.1 isoform X23

    UniProtKB/TrEMBL
    A0A0G2K161
    Conserved Domains (4) summary
    smart00295
    Location:210400
    B41; Band 4.1 homologues
    cd13184
    Location:395488
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:658706
    SAB; SAB domain
    pfam08736
    Location:498541
    FA; FERM adjacent (FA)
  50. XM_039111263.2XP_038967191.1  protein 4.1 isoform X20

    UniProtKB/TrEMBL
    A0A0G2K161
    Related
    ENSRNOP00000071712.3, ENSRNOT00000088493.3
    Conserved Domains (4) summary
    smart00295
    Location:210400
    B41; Band 4.1 homologues
    cd13184
    Location:395488
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:658706
    SAB; SAB domain
    pfam08736
    Location:498541
    FA; FERM adjacent (FA)
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