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epn1a epsin 1a [ Danio rerio (zebrafish) ]

Gene ID: 406671, updated on 9-Dec-2024

Summary

Official Symbol
epn1aprovided by ZNC
Official Full Name
epsin 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2680
See related
Ensembl:ENSDARG00000010411 AllianceGenome:ZFIN:ZDB-GENE-040426-2680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
epn1; fd51f09; zgc:56381; wu:fd51f09; wu:fj90e03
Summary
Predicted to enable clathrin binding activity and phospholipid binding activity. Predicted to be involved in endocytosis. Predicted to be located in cytoplasm. Predicted to be part of clathrin vesicle coat. Predicted to be active in endosome and plasma membrane. Orthologous to human EPN1 (epsin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See epn1a in Genome Data Viewer
Location:
chromosome: 16
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (12730311..12756528)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (12840191..12866408)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene microfibril associated protein 5 Neighboring gene SH3 domain binding kinase family, member 3 Neighboring gene forkhead box J2 Neighboring gene isochorismatase domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables clathrin binding  
enables lipid binding  
enables phospholipid binding  
Process Evidence Code Pubs
involved_in endocytosis  
Component Evidence Code Pubs
part_of clathrin vesicle coat  
located_in cytoplasm  
is_active_in endosome  
is_active_in plasma membrane  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328116.1NP_001315045.1  epsin-1

    Status: VALIDATED

    Source sequence(s)
    CR848818, EH439306, EH555046
    UniProtKB/TrEMBL
    A0A0R4IUB6, A0A8M1P8T3, F1Q5Z9
    Related
    ENSDARP00000138794.2, ENSDART00000162030.2
    Conserved Domains (4) summary
    smart00726
    Location:190208
    UIM; Ubiquitin-interacting motif
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    pfam05104
    Location:233371
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
    cl00427
    Location:317371
    TM_PBP2; Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    12730311..12756528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213932.1XP_068070033.1  epsin-1 isoform X5

    UniProtKB/TrEMBL
    A0A8M2B4R0, F1Q5Z9
  2. XM_068213929.1XP_068070030.1  epsin-1 isoform X3

    UniProtKB/TrEMBL
    F1Q5Z9
  3. XM_068213931.1XP_068070032.1  epsin-1 isoform X4

    UniProtKB/TrEMBL
    F1Q5Z9
  4. XM_068213935.1XP_068070036.1  epsin-1 isoform X7

    UniProtKB/TrEMBL
    F1Q5Z9
  5. XM_009292094.4XP_009290369.1  epsin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AIX1, F1Q5Z9
    Conserved Domains (4) summary
    smart00726
    Location:190208
    UIM; Ubiquitin-interacting motif
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    pfam05104
    Location:233371
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
    cl00427
    Location:317371
    TM_PBP2; Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and ...
  6. XM_009292096.4XP_009290371.1  epsin-1 isoform X9

    UniProtKB/TrEMBL
    A0A8M3AT63, F1Q5Z9
    Conserved Domains (3) summary
    smart00726
    Location:190208
    UIM; Ubiquitin-interacting motif
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    pfam08430
    Location:457564
    Forkhead_N; Forkhead N-terminal region
  7. XM_068213928.1XP_068070029.1  epsin-1 isoform X2

    UniProtKB/TrEMBL
    F1Q5Z9
  8. XM_005157886.5XP_005157943.1  epsin-1 isoform X5

    UniProtKB/TrEMBL
    A0A8M2B4R0, F1Q5Z9
    Conserved Domains (5) summary
    smart00726
    Location:190209
    UIM; Ubiquitin-interacting motif
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    pfam04871
    Location:191242
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    pfam05104
    Location:200340
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
    cl00427
    Location:286340
    TM_PBP2; Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and ...
  9. XM_068213933.1XP_068070034.1  epsin-1 isoform X6

    UniProtKB/TrEMBL
    F1Q5Z9
  10. XM_068213930.1XP_068070031.1  epsin-1 isoform X4

    UniProtKB/TrEMBL
    F1Q5Z9
  11. XM_068213934.1XP_068070035.1  epsin-1 isoform X7

    UniProtKB/TrEMBL
    F1Q5Z9
  12. XM_068213936.1XP_068070037.1  epsin-1 isoform X8

    UniProtKB/TrEMBL
    F1Q5Z9

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