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gad2 glutamate decarboxylase 2 [ Danio rerio (zebrafish) ]

Gene ID: 550403, updated on 4-Jan-2025

Summary

Official Symbol
gad2provided by ZNC
Official Full Name
glutamate decarboxylase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030909-9
See related
Ensembl:ENSDARG00000015537 AllianceGenome:ZFIN:ZDB-GENE-030909-9
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
GAD65; zgc:112198
Summary
Predicted to enable glutamate decarboxylase activity. Acts upstream of or within gamma-aminobutyric acid biosynthetic process. Predicted to be located in several cellular components, including Golgi membrane; cytosol; and presynaptic membrane. Predicted to be active in cytoplasm. Is expressed in central nervous system; eye; and neurons. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; diabetes mellitus (multiple); drug psychosis; and heroin dependence. Orthologous to human GAD2 (glutamate decarboxylase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See gad2 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (6133145..6158933, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (6103816..6129604, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489208 Neighboring gene NELL (neural EGFL like) family member 3 Neighboring gene myosin IIIA Neighboring gene uncharacterized LOC137489209 Neighboring gene uncharacterized LOC108181524

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carbon-carbon lyase activity  
enables carboxy-lyase activity  
enables glutamate decarboxylase activity  
enables glutamate decarboxylase activity  
enables lyase activity  
enables pyridoxal phosphate binding  
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi membrane  
located_in cell projection  
is_active_in cellular_component  
is_active_in cytoplasm  
located_in cytoplasmic vesicle  
located_in cytosol  
located_in membrane  
located_in plasma membrane  
located_in presynaptic membrane  
located_in synapse  

General protein information

Preferred Names
glutamate decarboxylase 2
NP_001017708.2
XP_068073170.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017708.2NP_001017708.2  glutamate decarboxylase 2

    Status: PROVISIONAL

    Source sequence(s)
    BX530066, CR855137
    UniProtKB/TrEMBL
    A0A8M1N545, F1R9E8
    Related
    ENSDARP00000010443.8, ENSDART00000021609.10
    Conserved Domains (2) summary
    pfam00282
    Location:136506
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    cl21457
    Location:511561
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    6133145..6158933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068217069.1XP_068073170.1  glutamate decarboxylase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PG03
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