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nuak2 NUAK family, SNF1-like kinase, 2 [ Danio rerio (zebrafish) ]

Gene ID: 560275, updated on 4-Jan-2025

Summary

Official Symbol
nuak2provided by ZNC
Official Full Name
NUAK family, SNF1-like kinase, 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050208-563
See related
Ensembl:ENSDARG00000063661 AllianceGenome:ZFIN:ZDB-GENE-050208-563
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:rp71-11b17.3
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See nuak2 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (508310..535454)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (470362..497731)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 2 Neighboring gene dual serine/threonine and tyrosine protein kinase Neighboring gene cyclin D3 Neighboring gene bystin-like

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding  
enables kinase activity  
enables nucleotide binding  
enables protein kinase activity  
enables protein serine/threonine kinase activity  
enables transferase activity  

General protein information

Preferred Names
NUAK family SNF1-like kinase 2
XP_688764.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    508310..535454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_683672.10XP_688764.3  NUAK family SNF1-like kinase 2

    UniProtKB/TrEMBL
    A0A8N7TD19
    Related
    ENSDARP00000116197.1, ENSDART00000135403.2
    Conserved Domains (2) summary
    smart00220
    Location:29279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14161
    Location:25279
    STKc_NUAK2; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2
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