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ULP2 SUMO protease ULP2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854780, updated on 4-Jan-2025

Summary

Official Symbol
ULP2
Official Full Name
SUMO protease ULP2
Primary source
SGD:S000001293
Locus tag
YIL031W
See related
AllianceGenome:SGD:S000001293; FungiDB:YIL031W; VEuPathDB:YIL031W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SMT4
Summary
Enables deSUMOylase activity and transcription elongation factor activity. Involved in several processes, including mitotic spindle assembly checkpoint signaling; plasmid maintenance; and protein desumoylation. Located in chromatin and nucleus. Used to study acute promyelocytic leukemia. Orthologous to human SENP7 (SUMO specific peptidase 7). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See ULP2 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (292633..295737)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene F-actin-capping protein subunit beta Neighboring gene cAMP-dependent protein kinase regulatory subunit BCY1 Neighboring gene E3 ubiquitin-protein ligase SSM4 Neighboring gene tRNA-Lys

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Process Evidence Code Pubs
involved_in chromosome condensation PubMed 
involved_in mitotic spindle assembly checkpoint signaling PubMed 
involved_in plasmid maintenance PubMed 
involved_in protein desumoylation  
involved_in protein desumoylation PubMed 
involved_in protein desumoylation PubMed 
involved_in proteolysis  
Component Evidence Code Pubs
located_in chromatin PubMed 
is_active_in nucleus  
located_in nucleus PubMed 

General protein information

Preferred Names
SUMO protease ULP2
NP_012233.1
  • Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins; plays a role in chromosome cohesion at centromeric regions, recovery from checkpoint arrest induced by DNA damage or DNA replication defect, and RNA splicing; potential Cdc28p substrate; human homolog PML implicated in promyelocytic leukemia can partially complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    292633..295737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179381.1NP_012233.1  TPA: SUMO protease ULP2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012233.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVQ0, P40537
    UniProtKB/TrEMBL
    A6ZVN7, B3LTN7, C7GVW0, C8ZAL5, N1P0M7
    Conserved Domains (1) summary
    COG5160
    Location:45695
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
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