familial adenomatous polyposis

Summary
Synonym
  • adenomatous polyposis of the colon
Definition
An intestinal disease that has_material_basis_in mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.
Super Class
autosomal genetic disease intestinal disease
Disease Ontology
DOID:0050424
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
ORDO
OMIM
GARD
MGI genotype (from TogoID)
Related Genes
Displaying all 4 entries
Gene ID Gene Symbol Description Source
324 APC APC regulator of WNT signaling pathway
3549 IHH Indian hedgehog signaling molecule
4595 MUTYH mutY DNA glycosylase
5335 PLCG1 phospholipase C gamma 1
Displaying all 2 entries
Gene ID Gene Symbol Description Source
16147 Ihh Indian hedgehog
70603 Mutyh mutY DNA glycosylase
Displaying 1 entry
Gene ID Gene Symbol Description Source
170841 Mutyh mutY DNA glycosylase
Displaying 1 entry
Gene ID Gene Symbol Description Source
43565 Axn Axin
Displaying 1 entry
Gene ID Gene Symbol Description Source
180349 grd-2 Ground-like domain-containing protein
Displaying 1 entry
Gene ID Gene Symbol Description Source
855897 HRR25 serine/threonine protein kinase HRR25

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 9, 2024