hereditary diffuse gastric cancer

Summary
Definition
A diffuse gastric cancer that is characterized by characterized by the development of diffuse (signet ring cell) gastric cancer at a young age, associated with germline heterozygous mutations of CDH1, MAP3K6 and CTNNA1 genes.
Super Class
autosomal dominant disease diffuse gastric cancer
Disease Ontology
DOID:0080764
Mondo Disease Ontology
GARD
Related Genes
Displaying 1 entry
Gene ID Gene Symbol Description Source
999 CDH1 cadherin 1
Related Glycoprotein
Displaying 1 entry
UniProt ID Protein Name Source
P12830 Cadherin-1

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025