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megaconial type congenital muscular dystrophy
Summary
- Synonym
-
- congenital megaconial myopathy
- congenital muscular dystrophy due to phosphatidylcholine biosynthesis defect
- congenital muscular dystrophy with mitochondrial structural abnormalities
- megaconial congenital muscular dystrophy
- Definition
- A congenital muscular dystrophy characterized by autosomal recessive inheritance of early-onset muscle wasting and intellectual disability with enlarged mitochondria that are more prevalent towards the periphery of the fibers that has_material_basis_in homozygous or compound heterozygous mutation in the CHKB gene on chromosome 22q13.
- Super Class
- autosomal recessive disease congenital muscular dystrophy
External Links
- Disease Ontology
- DOID:0110632
- Mondo Disease Ontology
- ORDO
- OMIM
- MGI genotype (from TogoID)
Related Genes
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0003236 | Elevated circulating creatine kinase concentration |
| HP:0001250 | Seizure |
| HP:0003677 | Slowly progressive |
| HP:0001644 | Dilated cardiomyopathy |
| HP:0010628 | Facial palsy |
| HP:0001290 | Generalized hypotonia |
| HP:0003560 | Muscular dystrophy |
| HP:0000750 | Delayed speech and language development |
| HP:0002515 | Waddling gait |
