primary angle-closure glaucoma

Summary
Synonym
  • primary Angle Closure Glaucoma
Definition
An angle-closure glaucoma characterized by closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Primary angle-closure glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Primary angle closure glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component.
Super Class
angle-closure glaucoma
External Links
Disease Ontology
DOID:1405
Mondo Disease Ontology
UMLS
WikiPathways (from TogoID)
Related Genes
Displaying all 9 entries
Gene ID Gene Symbol Description Source
847 CAT catalase
1103 CHAT choline O-acetyltransferase
1109 AKR1C4 aldo-keto reductase family 1 member C4
1545 CYP1B1 cytochrome P450 family 1 subfamily B member 1
1555 CYP2B6 cytochrome P450 family 2 subfamily B member 6
1634 DCN decorin
4907 NT5E 5'-nucleotidase ecto
4968 OGG1 8-oxoguanine DNA glycosylase
8818 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024