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solute carrier family 1 member 1

Summary

Gene Symbol

SLC1A1

Organism

Oryctolagus cuniculus (rabbit)

External Links

NCBI Gene: 100009070
PubChem: 100009070

Annotation

Keyword

Amino-acid transport
Cell membrane
Chloride
Endosome
Glycoprotein
Metal-binding
Phosphoprotein
Potassium
Reference proteome
Sodium
Symport
Synaptosome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P31597	Excitatory amino-acid carrier 1 Sodium-dependent glutamate/aspartate transporter 3 Solute carrier family 1 member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
L-glutamate transmembrane transport	IEA	30032202
cysteine transport
D-aspartate import across plasma membrane
L-glutamate import across plasma membrane
L-aspartate import across plasma membrane

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

D-aspartate import across plasma membrane

D-aspartate transport [inference]

D-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

amino acid transport [inference]

sulfur amino acid transport [inference]

cysteine transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

neutral amino acid transport [inference]

cysteine transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transport [inference]

D-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

D-aspartate import across plasma membrane

D-aspartate transport [inference]

D-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

amino acid transport [inference]

sulfur amino acid transport [inference]

cysteine transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

neutral amino acid transport [inference]

cysteine transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transport [inference]

D-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

nitrogen compound transport [inference]

amino acid transport [inference]

sulfur amino acid transport [inference]

cysteine transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

neutral amino acid transport [inference]

cysteine transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transport [inference]

D-aspartate import across plasma membrane

amide transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

sulfur compound transport [inference]

sulfur amino acid transport [inference]

cysteine transport

import into cell [inference]

amino acid import across plasma membrane [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
plasma membrane	IEA	30032202
apical plasma membrane
early endosome membrane
late endosome membrane
neuron projection

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

bounding membrane of organelle [inference]

endosome membrane [inference]

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
L-glutamate transmembrane transporter activity	IEA	30032202
high-affinity L-glutamate transmembrane transporter activity
chloride transmembrane transporter activity
glutamate:sodium symporter activity	IEA	30032202
cysteine transmembrane transporter activity	IEA	30032202

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

cysteine transmembrane transporter activity

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity [inference]

cysteine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

cysteine transmembrane transporter activity

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity [inference]

cysteine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

amide transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

sulfur compound transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

cysteine transmembrane transporter activity

salt transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

chloride transmembrane transporter activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Amino acid transporter

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
L-alpha-amino acid transmembrane transport
L-glutamate transmembrane transporter activity
neutral L-amino acid transmembrane transporter activity
symporter activity

Displaying **all 3** entries
InterPro
Sodium
Sodium
Sodium

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	6505	HUMAN96340
Mus musculus	20510	MOUSE25161
Rattus norvegicus	25550	RATNO20636
Bos taurus	282353	BOVIN34380
Sus scrofa	397003	PIGXX15512
Canis lupus familiaris	403751	CANLF00466
Danio rerio	436939	DANRE40390
Ovis aries	443514	SHEEP09109
Pan troglodytes	464974	PANTR43579
Macaca mulatta	694947	MACMU11917

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Acknowledgements