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Guidelines

MIRAGE

adrenoceptor alpha 1A

Summary

Gene Symbol

ADRA1A

Organism

Oryctolagus cuniculus (rabbit)

External Links

NCBI Gene: 100009237
PubChem: 100009237

Annotation

Keyword

Cell membrane
Cytoplasm
G-protein coupled receptor
Glycoprotein
Nucleus
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9MZU2	Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor
O02824	Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor
Q9MZU3	Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
MAPK cascade
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
positive regulation of heart rate by epinephrine-norepinephrine	IEA	30032202
positive regulation of the force of heart contraction by epinephrine-norepinephrine

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

neuron-glial cell signaling

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

intracellular signal transduction [inference]

MAPK cascade

cell growth [inference]

developmental cell growth [inference]

cell growth involved in cardiac muscle cell development

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

vasoconstriction [inference]

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

heart development [inference]

adult heart development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

cell growth involved in cardiac muscle cell development

developmental growth [inference]

developmental cell growth [inference]

cell growth involved in cardiac muscle cell development

response to stimulus [inference]

response to external stimulus [inference]

reflex [inference]

pilomotor reflex

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

signaling [inference]

cell-cell signaling

neuron-glial cell signaling

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of vasoconstriction

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

positive regulation of heart rate [inference]

positive regulation of heart rate by epinephrine-norepinephrine

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of multicellular organismal process [inference]

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

intracellular signal transduction [inference]

MAPK cascade

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction [inference]

positive regulation of smooth muscle contraction

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

regulation of muscle hypertrophy [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of the force of heart contraction [inference]

regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

regulation of heart rate [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

positive regulation of heart rate [inference]

positive regulation of heart rate by epinephrine-norepinephrine

negative regulation of heart contraction [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

positive regulation of heart rate [inference]

positive regulation of heart rate by epinephrine-norepinephrine

regulation of cardiac muscle contraction

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

positive regulation of heart rate [inference]

positive regulation of heart rate by epinephrine-norepinephrine

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of vasoconstriction

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

positive regulation of heart rate [inference]

positive regulation of heart rate by epinephrine-norepinephrine

negative regulation of multicellular organismal process [inference]

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

regulation of biological quality [inference]

regulation of the force of heart contraction [inference]

regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

regulation of heart rate [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

positive regulation of heart rate [inference]

positive regulation of heart rate by epinephrine-norepinephrine

positive regulation of cytosolic calcium ion concentration

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

vasoconstriction [inference]

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
nucleus
nucleoplasm
cytoplasm
cytosol
plasma membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

nuclear membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
alpha1-adrenergic receptor activity	IEA	22301074 30032202
protein heterodimerization activity

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

protein dimerization activity [inference]

protein heterodimerization activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

adrenergic receptor activity [inference]

alpha-adrenergic receptor activity [inference]

alpha1-adrenergic receptor activity

Gene Ontology information from NCBI Gene and UniProt.

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Last updated: April 6, 2026