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dystroglycan 1

Summary

Gene Symbol

DAG1

Organism

Oryctolagus cuniculus (rabbit)

External Links

NCBI Gene: 100009278
KEGG Gene ID: ocu:100009278
PubChem: 100009278

Annotation

Keyword

Basement membrane
Cell membrane
Cytoskeleton
Direct protein sequencing
Disulfide bond
Glycoprotein
Nucleus
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q28685	Dystroglycan Dystrophin-associated glycoprotein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 28 in total

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GO Term	Evidence Code	PMID
epithelial tube branching involved in lung morphogenesis
branching involved in salivary gland morphogenesis
cellular response to organic cyclic compound
commissural neuron axon guidance
basement membrane organization

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule anchoring

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

retrograde trans-synaptic signaling [inference]

retrograde trans-synaptic signaling by trans-synaptic protein complex

trans-synaptic signaling by trans-synaptic complex [inference]

retrograde trans-synaptic signaling by trans-synaptic protein complex

signal transduction [inference]

intracellular signal transduction

ensheathment of neurons [inference]

axon ensheathment [inference]

peripheral nervous system axon ensheathment [inference]

myelination in peripheral nervous system

myelination [inference]

myelination in peripheral nervous system

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule anchoring

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

commissural neuron axon guidance

extracellular structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

branching involved in salivary gland morphogenesis

muscle attachment

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

branching involved in salivary gland morphogenesis

animal organ morphogenesis [inference]

heart morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium

morphogenesis of an epithelial sheet

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

branching involved in salivary gland morphogenesis

developmental maturation [inference]

anatomical structure maturation [inference]

nerve maturation

anatomical structure development [inference]

nerve development

response to stimulus [inference]

response to activity [inference]

response to muscle activity

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

cellular response to organic cyclic compound

cellular response to organic substance [inference]

cellular response to organic cyclic compound

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

retrograde trans-synaptic signaling [inference]

retrograde trans-synaptic signaling by trans-synaptic protein complex

trans-synaptic signaling by trans-synaptic complex [inference]

retrograde trans-synaptic signaling by trans-synaptic protein complex

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to cell periphery [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to membrane [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of receptor localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

positive regulation of developmental process [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of gastrulation

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition

positive regulation of developmental process [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

regulation of gastrulation

regulation of basement membrane assembly involved in embryonic body morphogenesis [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of extracellular matrix assembly [inference]

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of basement membrane assembly involved in embryonic body morphogenesis [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cellular component organization [inference]

regulation of synapse organization

positive regulation of cellular component organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of extracellular matrix organization [inference]

regulation of basement membrane organization [inference]

regulation of basement membrane assembly involved in embryonic body morphogenesis [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of extracellular matrix assembly [inference]

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of basement membrane assembly involved in embryonic body morphogenesis [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to cell periphery [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to membrane [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

regulation of gastrulation

regulation of basement membrane assembly involved in embryonic body morphogenesis [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of biological quality [inference]

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
extracellular region
basement membrane	IEA	30032202
extracellular space	IEA	30032202
nucleoplasm
cytoplasm

GO Hierarchy

cellular component

protein-containing complex [inference]

glycoprotein complex [inference]

dystrophin-associated glycoprotein complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

sarcolemma

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse [inference]

ribbon synapse [inference]

photoreceptor ribbon synapse

GABA-ergic synapse

anchoring junction [inference]

cell-cell junction

cell-substrate junction [inference]

focal adhesion

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix [inference]

basement membrane

node of Ranvier

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

actin-based cell projection [inference]

filopodium

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

contractile ring

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
virus receptor activity
dystroglycan binding
actin binding
calcium ion binding	IEA	22301074
structural constituent of muscle

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of muscle

binding [inference]

protein binding [inference]

dystroglycan binding

cytoskeletal protein binding [inference]

actinin binding [inference]

alpha-actinin binding

protein domain specific binding [inference]

SH2 domain binding

laminin binding

laminin-1 binding

exogenous protein binding [inference]

virus receptor activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding

extracellular matrix binding [inference]

laminin binding

laminin-1 binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dystroglycan

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
calcium ion binding
morphogenesis of an epithelium
muscle attachment
nerve development

Displaying **all 7** entries
InterPro
Alpha-dystroglycan N-terminal domain 2
Alpha-dystroglycan domain 2
Cadherin-like superfamily
DG-type SEA domain
Dystroglycan, C-terminal
Dystroglycan-type cadherin-like
Immunoglobulin-like fold

KEGG BRITE Database

Orthology

K06265

Name

dystroglycan 1

References

9175728

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements