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Guidelines

MIRAGE

hyaluronidase 2

Summary

Gene Symbol

HYAL2

Organism

Oryctolagus cuniculus (rabbit)

External Links

NCBI Gene: 100009375
KEGG Gene ID: ocu:100009375
PubChem: 100009375

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA	22301074 30032202
hyaluronan catabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytoplasmic vesicle	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
hyalurononglucosaminidase activity	IEA	22301074 30032202
hyaluronoglucuronidase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

hexosaminidase activity [inference]

hyalurononglucosaminidase activity

hyaluronoglucuronidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Hyaluronidase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
hyaluronan catabolic process
hyalurononglucosaminidase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity

Displaying **all 3** entries
InterPro
Aldolase-type TIM barrel
Glycoside hydrolase superfamily
Hyaluronidase

KEGG BRITE Database

Orthology

K01197

Name

hyaluronoglucosaminidase [EC:3.2.1.35]

References

Reactions

Displaying **all 3** entries
KEGG Reaction	Enzyme	Acceptor	Product
R07824	3.2.1.35	G81393WR	G92988PL
R10905	3.2.1.35	G16235VG	G16235VG G93263XO
R07825	3.2.1.35	G34586BV	G92988PL

Ortholog

Displaying entries **51 - 60** of **142** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Neolamprologus brichardi	102778078		NEOBR03369
Neolamprologus brichardi	102788678		NEOBR03490
Astyanax mexicanus	103032073		ASTMX16839
Astyanax mexicanus	103039131		ASTMX15713
Erinaceus europaeus	103117295		ERIEU01181
Poecilia formosa	103136956		POEFO00503
Poecilia formosa	103137977		POEFO00594
Callorhinchus milii	103176705		CALMI11308
Chlorocebus sabaeus	103227673		CHLSB10382
Carlito syrichta	103255457		CARSF12188

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.2.0

Last updated: March 31, 2025