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MIRAGE
inositol polyphosphate-5-phosphatase D

Summary
Gene Symbol
  • INPP5D
Organism
Monodelphis domestica (gray short-tailed opossum)
NCBI Gene
100021361
KEGG Gene ID
mdo:100021361
PubChem
100021361
Annotation
Keyword
  • Cytoskeleton
  • Immunity
  • Membrane
  • Reference proteome
  • SH2 domain
Proteins
Displaying all 3 entries
UniProt Protein Name
A0A5F8HIU2
A0A5F8GEZ3
F7GAI6
Annotation information from UniProt.
Gene Ontology (GO)
Displaying 1 entry
GO Term Evidence Code PMID
phosphatidylinositol dephosphorylation
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Functional Category
  • E: Amino acid transport and metabolism
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Displaying all 5 entries
Gene Ontology
immune system process
inositol-polyphosphate 5-phosphatase activity
negative regulation of insulin-like growth factor receptor signaling pathway
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
regulation of immune response
Displaying all 4 entries
InterPro
Endonuclease/exonuclease/phosphatase superfamily
Inositol polyphosphate-related phosphatase
SH2 domain superfamily
SH2 domain
KEGG BRITE Database
Orthology
K03084
Name
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
References
Rhea

RHEA:25528

H2O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)
phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate)
Enzyme
PMID
Ortholog
Displaying entries 1 - 10 of 78 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
3635 HUMAN67597
16331 MOUSE28732
54259 RATNO43166
470683 PANTR30064
507329 BOVIN27367
559103 DANRE39121
717832 MACMU05608
100064896 HORSE36454
100092282 ORNAN12145
100219581 TAEGU29981
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025