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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

cadherin 2

Summary

Gene Symbol

CDH2

Organism

Homo sapiens (human)

External Links

NCBI Gene

1000

PubChem

1000

Alliance of Genome Resources

HGNC:1759

JoGo

CDH2

TogoVar

CDH2

Annotation

Keyword

Alternative splicing
Calcium
Cardiomyopathy
Cell adhesion
Cell junction
Cell membrane
Cell projection
Cleavage on pair of basic residues
Disease variant
Glycoprotein
Intellectual disability
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
C9J126	Neural cadherin
P19022	CDw325 Neural cadherin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
cell morphogenesis	IBA
type B pancreatic cell development	ISS
cell-cell junction assembly	ISS
cell-cell junction assembly	IBA
cell adhesion	TAS	2384753

GO Hierarchy

biological process

cellular process [inference]

cell-cell adhesion

cell-cell adhesion mediated by cadherin

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

radial glial cell differentiation

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

neuroepithelial cell differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation

cell development [inference]

epithelial cell development [inference]

columnar/cuboidal epithelial cell development [inference]

glandular epithelial cell development [inference]

type B pancreatic cell development

stem cell development [inference]

neural crest cell development

cell motility [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction organization [inference]

synapse organization [inference]

synapse assembly

multicellular organismal process [inference]

stem cell population maintenance [inference]

neuronal stem cell population maintenance

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

animal organ morphogenesis [inference]

brain morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis

anatomical structure development [inference]

cerebral cortex development

cell development [inference]

epithelial cell development [inference]

columnar/cuboidal epithelial cell development [inference]

glandular epithelial cell development [inference]

type B pancreatic cell development

stem cell development [inference]

neural crest cell development

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

radial glial cell differentiation

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

neuroepithelial cell differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation

cell development [inference]

epithelial cell development [inference]

columnar/cuboidal epithelial cell development [inference]

glandular epithelial cell development [inference]

type B pancreatic cell development

stem cell development [inference]

neural crest cell development

maintenance of cell number [inference]

stem cell population maintenance [inference]

neuronal stem cell population maintenance

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of muscle stretch

response to mechanical stimulus [inference]

response to muscle stretch [inference]

detection of muscle stretch

detection of mechanical stimulus [inference]

detection of muscle stretch

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of muscle stretch

response to mechanical stimulus [inference]

response to muscle stretch [inference]

detection of muscle stretch

detection of mechanical stimulus [inference]

detection of muscle stretch

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of muscle stretch

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of muscle stretch

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

organelle localization [inference]

vesicle localization [inference]

synaptic vesicle localization [inference]

synaptic vesicle clustering

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of synaptic vesicle clustering

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to membrane [inference]

regulation of postsynaptic density protein 95 clustering

regulation of synaptic vesicle clustering [inference]

positive regulation of synaptic vesicle clustering

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of transport [inference]

positive regulation of synaptic vesicle clustering

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cell population proliferation [inference]

regulation of neural precursor cell proliferation [inference]

regulation of oligodendrocyte progenitor proliferation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of postsynaptic density organization [inference]

regulation of postsynaptic density protein 95 clustering

regulation of synapse organization [inference]

regulation of postsynapse organization [inference]

regulation of postsynaptic density organization [inference]

regulation of postsynaptic density protein 95 clustering

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to membrane [inference]

regulation of postsynaptic density protein 95 clustering

Displaying entries **21 - 25** of 33 in total

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GO Term	Evidence Code	PMID
lamellipodium	IDA	24046456
lamellipodium	IBA
cell junction	IDA	28169360
desmosome	ISS
cortical actin cytoskeleton	IDA	24046456

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

catenin complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

sarcolemma

plasma membrane region [inference]

synaptic membrane [inference]

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft

anchoring junction [inference]

cell-cell junction

cell-cell contact zone [inference]

intercalated disc

cell-substrate junction [inference]

focal adhesion

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
RNA binding	IEA
calcium ion binding	ISS
protein binding	IPI	17057644 17098867 17510365 17679699 18948590 21357690 29366904 33961781 35271311 36950384 7650039
beta-catenin binding	TAS	16344550
beta-catenin binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

beta-catenin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

phosphatase binding [inference]

protein phosphatase binding

cell adhesion molecule binding [inference]

cadherin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050431	arrhythmogenic right ventricular cardiomyopathy	Alliance of Genome Resources
DOID:0080948	agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Alliance of Genome Resources
DOID:0080959	arrhythmogenic right ventricular dysplasia 14	Alliance of Genome Resources

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026