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beta-secretase 1

Summary

Gene Symbol

Bace1

Organism

Cavia porcellus (domestic guinea pig)

External Links

NCBI Gene: 100135485
PubChem: 100135485

Annotation

Keyword

Acetylation
Aspartyl protease
Cell membrane
Cell projection
Cytoplasmic vesicle
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Isopeptide bond
Lysosome
Palmitate
Phosphoprotein
Reference proteome
Signal
Transmembrane helix
Ubl conjugation
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q1KLR6	Beta-site amyloid precursor protein cleaving enzyme 1 Memapsin-2 Membrane-associated aspartic protease 2
A0A2C9F1F3	Beta-site amyloid precursor protein cleaving enzyme 1 Memapsin-2 Membrane-associated aspartic protease 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
proteolysis
membrane protein ectodomain proteolysis	IEA	30032202
amyloid-beta metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

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GO Term	Evidence Code	PMID
recycling endosome
early endosome
Golgi apparatus
late endosome
cytoplasmic vesicle membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

membrane microdomain [inference]

membrane raft

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
aspartic-type endopeptidase activity	IEA	22301074 30032202
endopeptidase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

aspartic-type endopeptidase activity

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

aspartic-type endopeptidase activity

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

aspartic

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
aspartic-type endopeptidase activity
proteolysis

Displaying **all 6** entries
InterPro
Aspartic peptidase A1 family
Aspartic peptidase domain superfamily
Aspartic peptidase, active site
Peptidase family A1 domain
Xylanase inhibitor, C-terminal
Xylanase inhibitor, N-terminal

Ortholog

Displaying entries **1 - 10** of **114** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	23621		HUMAN09577
Mus musculus	23821	10090_1:00309f	MOUSE63151
Rattus norvegicus	29392	10116_1:002f6f	RATNO39964
Pan troglodytes	451573		PANTR04425
Bos taurus	614333		BOVIN06520
Macaca mulatta	697694		MACMU09930
Monodelphis domestica	100025518		MONDO25208
Equus caballus	100071137		HORSE39158
Ornithorhynchus anatinus	100079669		ORNAN02614
Oryctolagus cuniculus	100343442		RABIT00578