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Guidelines

MIRAGE

chloride voltage-gated channel 3

Summary

Gene Symbol

Clcn3

Organism

Cavia porcellus (domestic guinea pig)

External Links

NCBI Gene: 100135501
PubChem: 100135501

Annotation

Keyword

ATP-binding
Alternative splicing
Antiport
CBS domain
Cell membrane
Chloride
Endosome
Glycoprotein
Ion transport
Lysosome
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A2C9F1G0
H0UV02
P97274
Q9R279	Chloride channel protein 3 Chloride transporter ClC-3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
chloride transport	IEA	22301074
transmembrane transport	IEA	22301074

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport

inorganic anion transport [inference]

chloride transport

transmembrane transport

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
lysosomal membrane
early endosome	IEA	30032202
late endosome
Golgi apparatus	IEA	30032202
plasma membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
voltage-gated chloride channel activity	IEA	22301074 30032202
ATP binding
antiporter activity
PDZ domain binding

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

monoatomic anion channel activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

monoatomic anion channel activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

binding [inference]

protein binding [inference]

protein domain specific binding [inference]

PDZ domain binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

H(+)/Cl(-) exchange transporter

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
chloride transmembrane transport
chloride transport
monoatomic ion transport
voltage-gated chloride channel activity

Displaying **all 4** entries
InterPro
CBS domain superfamily
CBS domain
Chloride channel, core
Chloride channel, voltage gated

Ortholog

Displaying entries **21 - 30** of **102** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Nomascus leucogenys	100581879		NOMLE33639
Loxodonta africana	100677090		LOXAF08715
Oreochromis niloticus	100709611		ORENI49096
Cricetulus griseus	100759588		CRIGR05250
Sarcophilus harrisii	100914591		SARHA05181
Otolemur garnettii	100946211		OTOGA09558
Pan paniscus	100991399		PANPA31279
Papio anubis	101022664		PAPAN26634
Takifugu rubripes	101062139		TAKRU49454
Felis catus	101092513		FELCA09461

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025