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isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

Summary

Gene Symbol

IDH3A

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 100157242
KEGG Gene ID: ssc:100157242
PubChem: 100157242

Annotation

Keyword

Acetylation
Direct protein sequencing
Magnesium
Metal-binding
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A480YSS4
A0A8D0ZSH2
P56471	Isocitric dehydrogenase subunit alpha NAD(+)-specific ICDH subunit alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
isocitrate metabolic process	IEA	30032202
tricarboxylic acid cycle	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

primary metabolic process [inference]

tricarboxylic acid cycle

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
mitochondrion	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
NAD binding	IEA	22301074
magnesium ion binding	IEA	22301074
isocitrate dehydrogenase (NAD+) activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

isocitrate dehydrogenase [NAD(P)+] activity [inference]

isocitrate dehydrogenase (NAD+) activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

isocitrate dehydrogenase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
isocitrate dehydrogenase (NAD+) activity
isocitrate metabolic process
magnesium ion binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
tricarboxylic acid cycle

Displaying **all 3** entries
InterPro
Isocitrate dehydrogenase NAD-dependent
Isocitrate/isopropylmalate dehydrogenase, conserved site
Isopropylmalate dehydrogenase-like domain

KEGG BRITE Database

Orthology

K00030

Name

isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]

References

10601238

Rhea

D-threo-isocitrate + NAD⁺

CO₂ + 2-oxoglutarate + NADH

Enzyme

PMID

Ortholog

Displaying entries **1 - 10** of **103** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3419			HUMAN24501
Mus musculus	67834			MOUSE61155
Rattus norvegicus	114096			RATNO41456
Bos taurus	282446	9913_0:003e1f		BOVIN16568
Danio rerio	393926			DANRE27145
Pan troglodytes	453565			PANTR10900
Canis lupus familiaris	479066			CANLF12136
Macaca mulatta	677715			MACMU42784
Monodelphis domestica	100012825			MONDO03977
Equus caballus	100060114			HORSE16905

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024