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aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

Summary

Gene Symbol

AKR1C1

Organism

Pongo abelii (Sumatran orangutan)

External Links

NCBI Gene: 100171658
KEGG Gene ID: pon:100171658
PubChem: 100171658

Annotation

Keyword

Cytoplasm
Lipid metabolism
NADP
Oxidoreductase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5REQ0	20-alpha-hydroxysteroid dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
daunorubicin metabolic process	IEA	30032202
doxorubicin metabolic process	IEA	30032202
prostaglandin metabolic process	IEA	30032202
progesterone metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

secondary metabolic process [inference]

polyketide metabolic process [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

cellular aromatic compound metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

doxorubicin metabolic process

tertiary alcohol metabolic process [inference]

doxorubicin metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

polyketide metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

olefinic compound metabolic process [inference]

progesterone metabolic process

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

glycoside metabolic process [inference]

aminoglycoside antibiotic metabolic process [inference]

daunorubicin metabolic process

doxorubicin metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

doxorubicin metabolic process

tertiary alcohol metabolic process [inference]

doxorubicin metabolic process

cellular process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

cellular aromatic compound metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying **all 4** entries
GO Term	Evidence Code	PMID
androsterone dehydrogenase activity	IEA	30032202
bile acid binding	IEA	30032202
alditol:NADP+ 1-oxidoreductase activity	IEA	30032202
ketosteroid monooxygenase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

ketosteroid monooxygenase activity

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

androsterone dehydrogenase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

aldo-keto reductase (NADP) activity [inference]

alcohol dehydrogenase (NADP+) activity [inference]

alditol:NADP+ 1-oxidoreductase activity

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

androsterone dehydrogenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

ketosteroid monooxygenase activity

binding [inference]

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

bile acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

bile acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

aldo-keto reductase family 1 member C1

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying entries **1 - 10** of 16 in total

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Gene Ontology
alditol
androsterone dehydrogenase activity
bile acid binding
carboxylic acid binding
cellular response to jasmonic acid stimulus
daunorubicin metabolic process
digestion
doxorubicin metabolic process
estradiol 17-beta-dehydrogenase [NAD(P)] activity
ketosteroid monooxygenase activity

Displaying **all 5** entries
InterPro
Aldo-keto reductase family 1 member C
Aldo-keto reductase
Aldo/keto reductase, conserved site
NADP-dependent oxidoreductase domain superfamily
NADP-dependent oxidoreductase domain

Rhea

RHEA:16317

(S)-indan-1-ol + NAD⁺

H⁺ + indan-1-one + NADH

Enzyme

1.1.1.112

PMID

4397102

RHEA:24612

17β-estradiol + NAD⁺

H⁺ + estrone + NADH

Enzyme

1.1.1.62

PMID

RHEA:34779

a 3α-hydroxysteroid + NAD⁺

H⁺ + a 3-oxosteroid + NADH

Enzyme

PMID

RHEA:65220

(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP⁺

H⁺ + catechol + NADPH

Enzyme

1.3.1.20

PMID

RHEA:20377

androsterone + NADP⁺

H⁺ + 5α-androstan-3,17-dione + NADPH

Enzyme

1.1.1.209

PMID

RHEA:15857

(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP⁺

H⁺ + 17α-hydroxyprogesterone + NADPH

Enzyme

1.1.1.149

PMID

RHEA:16729

(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP⁺

H⁺ + catechol + NADPH

Enzyme

1.3.1.20

PMID

RHEA:20381

androsterone + NAD⁺

H⁺ + 5α-androstan-3,17-dione + NADH

Enzyme

1.1.1.209

PMID

RHEA:42004

5α-androstane-3α,17β-diol + NAD⁺

H⁺ + 17β-hydroxy-5α-androstan-3-one + NADH

Enzyme

1.1.1.53

PMID

RHEA:34783

a 3α-hydroxysteroid + NADP⁺

H⁺ + a 3-oxosteroid + NADPH

Enzyme

PMID

RHEA:16321

(S)-indan-1-ol + NADP⁺

H⁺ + indan-1-one + NADPH

Enzyme

1.1.1.112

PMID

RHEA:24616

17β-estradiol + NADP⁺

H⁺ + estrone + NADPH

Enzyme

1.1.1.62

PMID

RHEA:14929

testosterone + NAD⁺

H⁺ + androst-4-ene-3,17-dione + NADH

Enzyme

PMID

RHEA:14981

testosterone + NADP⁺

H⁺ + androst-4-ene-3,17-dione + NADPH

Enzyme

PMID

RHEA:22400

androstan-3α,17β-diol + NAD⁺

H⁺ + NADH + 17β-hydroxyandrostanone

Enzyme

1.1.1.53

PMID

RHEA:16297

5α-androstane-3β,17β-diol + NADP⁺

H⁺ + 17β-hydroxy-5α-androstan-3-one + NADPH

Enzyme

1.1.1.210

PMID

RHEA:15853

(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD⁺

H⁺ + 17α-hydroxyprogesterone + NADH

Enzyme

1.1.1.149

PMID

Ortholog

Displaying entries **1 - 10** of 22 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	1645	9606_1:00298e	HUMAN00099
Homo sapiens	1646	9606_1:0029ae	HUMAN00102
Macaca mulatta	711198		MACMU44830
Macaca mulatta	711440		MACMU44830
Ornithorhynchus anatinus	100085065		ORNAN04476
Nomascus leucogenys	100603603		NOMLE37906
Nomascus leucogenys	100605934		NOMLE36853
Pan troglodytes	100607996	9598_0:002dab
Pan troglodytes	100612191	9598_0:002d3b
Pan paniscus	100986729	9597_0:002c6e	PANPA04252

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements