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Guidelines

MIRAGE

semaphorin 3C

Summary

Gene Symbol

SEMA3C

Organism

Pongo abelii (Sumatran orangutan)

External Links

NCBI Gene: 100171774
PubChem: 100171774

Annotation

Keyword

Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Neurogenesis
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q5RE75
A0A2J8VLI3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
neural crest cell migration	IEA	30032202
somitogenesis
blood vessel remodeling
outflow tract septum morphogenesis
cardiac right ventricle morphogenesis

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

cardiac endothelial to mesenchymal transition

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

somitogenesis

segmentation [inference]

somitogenesis

post-embryonic development

tissue remodeling [inference]

blood vessel remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

cardiac chamber morphogenesis [inference]

cardiac ventricle morphogenesis [inference]

cardiac right ventricle morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

dichotomous subdivision of an epithelial terminal unit [inference]

dichotomous subdivision of terminal units involved in salivary gland branching

cardiac septum morphogenesis [inference]

outflow tract septum morphogenesis

anatomical structure formation involved in morphogenesis [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

neural tube development

muscle tissue development [inference]

striated muscle tissue development [inference]

pulmonary myocardium development

tube development [inference]

neural tube development

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

cardiac endothelial to mesenchymal transition

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [inference]

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [inference]

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular space	IEA	30032202
plasma membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
semaphorin receptor binding	IEA	30032202
chemorepellent activity	IEA	30032202

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

semaphorin receptor binding

receptor ligand activity [inference]

chemorepellent activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

semaphorin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
chemorepellent activity
negative regulation of axon extension involved in axon guidance
neural crest cell migration
positive regulation of cell migration
semaphorin receptor binding
semaphorin-plexin signaling pathway

Displaying **all 5** entries
InterPro
PSI domain
Sema domain superfamily
Sema domain
Semaphorin
WD40/YVTN repeat-like-containing domain superfamily

Ortholog

Displaying entries **21 - 30** of 91 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Cavia porcellus	100730457		CAVPO14296
Cricetulus griseus	100765927		CRIGR13282
Sarcophilus harrisii	100915955		SARHA03040
Otolemur garnettii	100962931		OTOGA17862
Pan paniscus	100984137		PANPA36543
Papio anubis	101019247		PAPAN30491
Saimiri boliviensis boliviensis	101044556		SAIBB02351
Felis catus	101094086		FELCA05329
Ovis aries	101114604		SHEEP15396
Gorilla gorilla gorilla	101126899		GORGO38543

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: February 17, 2025