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Guidelines

MIRAGE

SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3

Summary

Gene Symbol

SPOCK3

Organism

Pongo abelii (Sumatran orangutan)

External Links

NCBI Gene: 100172015
PubChem: 100172015

Annotation

Keyword

Alternative splicing
Calcium
Disulfide bond
Extracellular matrix
Heparan sulfate
Metalloprotease inhibitor
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A2J8VZZ4
Q5RD69	SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
negative regulation of peptidase activity
anatomical structure development	IEA	30032202

GO Hierarchy

biological process

developmental process [inference]

anatomical structure development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular space	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
calcium ion binding	IEA	22301074 30032202
protein binding	IEA	22301074
collagen binding	IEA	30032202
glycosaminoglycan binding
peptidase inhibitor activity

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

collagen binding

extracellular matrix binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Testican-1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
calcium ion binding
collagen binding
extracellular matrix binding

Displaying **all 4** entries
InterPro
EF-hand domain pair
SPARC/Testican, calcium-binding domain
Thyroglobulin type-1 superfamily
Thyroglobulin type-1

Ortholog

Displaying entries **1 - 10** of 52 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	50859		HUMAN78041
Mus musculus	72902		MOUSE58666
Rattus norvegicus	306404		RATNO11260
Pan troglodytes	461594		PANTR34769
Danio rerio	562002		DANRE18370
Macaca mulatta	705964		MACMU37227
Monodelphis domestica	100015522		MONDO28103
Equus caballus	100067749		HORSE27480
Ornithorhynchus anatinus	100075008		ORNAN04333
Sus scrofa	100154805		PIGXX06604

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.2.1

Last updated: April 7, 2025