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potassium two pore domain channel subfamily K member 1

Summary

Gene Symbol

KCNK1

Organism

Pongo abelii (Sumatran orangutan)

External Links

NCBI Gene: 100172055
PubChem: 100172055

Annotation

Keyword

Cell membrane
Cell projection
Cytoplasmic vesicle
Disulfide bond
Endosome
Glycoprotein
Isopeptide bond
Phosphoprotein
Potassium channel
Reference proteome
Synapse
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5RD07

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
glutamate secretion
stabilization of membrane potential	IEA	30032202
sodium ion transmembrane transport
regulation of resting membrane potential
potassium ion transmembrane transport	IEA	22301074 30032202

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

export from cell [inference]

secretion by cell [inference]

glutamate secretion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

secretion [inference]

secretion by cell [inference]

glutamate secretion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

glutamate secretion

amino acid transport [inference]

acidic amino acid transport [inference]

glutamate secretion

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

glutamate secretion

amino acid transport [inference]

acidic amino acid transport [inference]

glutamate secretion

nitrogen compound transport [inference]

amino acid transport [inference]

acidic amino acid transport [inference]

glutamate secretion

amide transport [inference]

glutamate secretion

export from cell [inference]

secretion by cell [inference]

glutamate secretion

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane potential [inference]

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
plasma membrane	IEA	30032202
membrane
apical plasma membrane
dendrite
potassium channel complex

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
potassium channel activity
sodium channel activity
outward rectifier potassium channel activity	IEA	30032202
ligand-gated channel activity
potassium ion leak channel activity	IEA	30032202

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

potassium ion leak channel activity

sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

potassium ion leak channel activity

sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

potassium ion leak channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

potassium ion leak channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

potassium ion leak channel activity

sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

ligand-gated channel activity

narrow pore channel activity [inference]

leak channel activity [inference]

potassium ion leak channel activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity

voltage-gated potassium channel activity [inference]

outward rectifier potassium channel activity

potassium ion leak channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity

binding [inference]

protein binding [inference]

identical protein binding

protein dimerization activity [inference]

protein heterodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Potassium channel

Functional Category

E: Amino acid transport and metabolism
K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
monoatomic ion transport
outward rectifier potassium channel activity
potassium channel activity
potassium ion leak channel activity
stabilization of membrane potential

Displaying **all 2** entries
InterPro
Potassium channel domain
Two pore domain potassium channel

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	3775	HUMAN55239
Mus musculus	16525	MOUSE59649
Rattus norvegicus	59324	RATNO14836
Pan troglodytes	469712	PANTR23953
Bos taurus	505563	BOVIN22285
Danio rerio	561206	DANRE04945
Macaca mulatta	718815	MACMU23152
Oryctolagus cuniculus	100008962	RABIT05619
Monodelphis domestica	100021584	MONDO15430
Equus caballus	100059489	HORSE18252