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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

nei like DNA glycosylase 2

Summary

Gene Symbol

NEIL2

Organism

Pongo abelii (Sumatran orangutan)

External Links

NCBI Gene: 100172638
PubChem: 100172638

Annotation

Keyword

Acetylation
DNA repair
DNA-binding
Glycosidase
Lyase
Multifunctional enzyme
Nucleus
Phosphoprotein
Reference proteome
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5RAJ7	DNA glycosylase/AP lyase Neil2 DNA-(apurinic or apyrimidinic site) lyase Neil2 Endonuclease VIII-like 2 Nei-like protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
base-excision repair	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

Displaying 1 entry
GO Term	Evidence Code	PMID
nucleus

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
damaged DNA binding	IEA	22301074
DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA	22301074 30032202
zinc ion binding	IEA	22301074
DNA N-glycosylase activity	IEA	22301074 30032202
class I DNA-(apurinic or apyrimidinic site) endonuclease activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA-(apurinic or apyrimidinic site) endonuclease activity

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA N-glycosylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endonuclease 8-like 2

Functional Category

H: Coenzyme transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 12 in total

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Gene Ontology
DNA repair
DNA-(apurinic or apyrimidinic site) endonuclease activity
base-excision repair
catalytic activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
damaged DNA binding
endonuclease activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing N-glycosyl compounds
hydrolase activity

Displaying **all 3** entries
InterPro
DNA glycosylase/AP lyase, H2TH DNA-binding
Formamidopyrimidine-DNA glycosylase, catalytic domain
Small ribosomal subunit protein uS13-like, H2TH

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	252969		HUMAN92494
Rattus norvegicus	305957		RATNO09535
Mus musculus	382913		MOUSE12664
Bos taurus	444987		BOVIN34137
Pan troglodytes	463992		PANTR41979
Canis lupus familiaris	486078		CANLF09929
Macaca mulatta	696647		MACMU43221
Monodelphis domestica	100032683		MONDO04037
Equus caballus	100065246		HORSE27102
Taeniopygia guttata	100226151		TAEGU22153

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025