GlyCosmos Portal

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solute carrier family 7 member 11

Summary

Gene Symbol

SLC7A11

Organism

Pongo abelii (Sumatran orangutan)

External Links

NCBI Gene: 100172659
PubChem: 100172659

Annotation

Keyword

Amino-acid transport
Cell membrane
Cell projection
Disulfide bond
Glycoprotein
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5RAG7	Amino acid transport system xc- Solute carrier family 7 member 11 xCT

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
amino acid transmembrane transport	IEA	30032202
L-cystine transport
L-glutamate transmembrane transport
negative regulation of ferroptosis
L-kynurenine transmembrane transport

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

modified amino acid transport [inference]

L-cystine transport

nitrogen compound transport [inference]

amino acid transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

amide transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

modified amino acid transport [inference]

L-cystine transport

sulfur compound transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane
membrane	IEA	22301074
microvillus membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

microvillus membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
L-amino acid transmembrane transporter activity	IEA	30032202
cystine:glutamate antiporter activity
L-kynurenine transmembrane transporter activity

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

sulfur-containing amino acid secondary active transmembrane transporter activity [inference]

cystine secondary active transmembrane transporter activity [inference]

cystine:glutamate antiporter activity

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity [inference]

cystine:glutamate antiporter activity

neutral L-amino acid transmembrane transporter activity [inference]

neutral L-amino acid secondary active transmembrane transporter activity [inference]

cystine secondary active transmembrane transporter activity [inference]

cystine:glutamate antiporter activity

L-amino acid transmembrane transporter activity

L-glutamate transmembrane transporter activity [inference]

cystine:glutamate antiporter activity

L-kynurenine transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

sulfur-containing amino acid secondary active transmembrane transporter activity [inference]

cystine secondary active transmembrane transporter activity [inference]

cystine:glutamate antiporter activity

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity [inference]

cystine:glutamate antiporter activity

neutral L-amino acid transmembrane transporter activity [inference]

neutral L-amino acid secondary active transmembrane transporter activity [inference]

cystine secondary active transmembrane transporter activity [inference]

cystine:glutamate antiporter activity

L-amino acid transmembrane transporter activity

L-glutamate transmembrane transporter activity [inference]

cystine:glutamate antiporter activity

L-kynurenine transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

neutral L-amino acid secondary active transmembrane transporter activity [inference]

cystine secondary active transmembrane transporter activity [inference]

cystine:glutamate antiporter activity

antiporter activity [inference]

cystine:glutamate antiporter activity

sulfur-containing amino acid secondary active transmembrane transporter activity [inference]

cystine secondary active transmembrane transporter activity [inference]

cystine:glutamate antiporter activity

amide transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity [inference]

cystine:glutamate antiporter activity

modified amino acid transmembrane transporter activity [inference]

cystine secondary active transmembrane transporter activity [inference]

cystine:glutamate antiporter activity

sulfur compound transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

sulfur-containing amino acid secondary active transmembrane transporter activity [inference]

cystine secondary active transmembrane transporter activity [inference]

cystine:glutamate antiporter activity

salt transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity [inference]

cystine:glutamate antiporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

amino acid transporter

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
L-amino acid transmembrane transporter activity

Displaying 1 entry
InterPro
Amino acid/polyamine transporter I

Ortholog

Displaying entries **1 - 10** of 77 in total

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Mus musculus	26570	MOUSE37458
Rattus norvegicus	310392	RATNO25551
Pan troglodytes	471310	PANTR34495
Canis lupus familiaris	483821	CANLF06249
Macaca mulatta	696516	MACMU36267
Ornithorhynchus anatinus	100091177	ORNAN23605
Danio rerio	100151597	DANRE06647
Taeniopygia guttata	100223276	TAEGU23568
Oryctolagus cuniculus	100349263	RABIT05120