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farnesyl-diphosphate farnesyltransferase 1

Summary

Gene Symbol

FDFT1

Organism

Pongo abelii (Sumatran orangutan)

External Links

NCBI Gene: 100173463
KEGG Gene ID: pon:100173463
PubChem: 100173463

Annotation

Keyword

Cholesterol biosynthesis
Endoplasmic reticulum
Isoprene biosynthesis
Magnesium
Metal-binding
Multifunctional enzyme
NAD
NADP
Reference proteome
Transferase
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A2J8X3H0
A0A2J8X3G8
A0A8I5TFJ2	FPP:FPP farnesyltransferase Farnesyl-diphosphate farnesyltransferase
Q5R6U3	FPP:FPP farnesyltransferase Farnesyl-diphosphate farnesyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cholesterol biosynthetic process	IEA	30032202
farnesyl diphosphate metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

farnesyl diphosphate metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

farnesyl diphosphate metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

farnesyl diphosphate metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

farnesyl diphosphate metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

farnesyl diphosphate metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
squalene synthase activity	IEA	30032202
farnesyl-diphosphate farnesyltransferase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

prenyltransferase activity [inference]

farnesyltranstransferase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00801

Name

farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21]

References

Rhea

RHEA:32295

H⁺ + (2E,6E)-farnesyl diphosphate + NADPH

squalene + diphosphate + NADP⁺

Enzyme

2.5.1.21

PMID

RHEA:32299

H⁺ + (2E,6E)-farnesyl diphosphate + NADH

squalene + diphosphate + NAD⁺

Enzyme

2.5.1.21

PMID

Ortholog

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