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hepsin

Summary

Gene Symbol

Organism

Pongo abelii (Sumatran orangutan)

External Links

NCBI Gene: 100173788
PubChem: 100173788

Annotation

Keyword

Disulfide bond
Glycoprotein
Reference proteome
Serine protease
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5R5E8	Transmembrane protease serine 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
proteolysis	IEA	22301074
regulation of cell shape
positive regulation of gene expression
negative regulation of epithelial to mesenchymal transition
positive regulation of plasminogen activation

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly [inference]

basement membrane disassembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly [inference]

basement membrane disassembly

basement membrane organization [inference]

basement membrane disassembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly [inference]

basement membrane disassembly

basement membrane organization [inference]

basement membrane disassembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

detection of mechanical stimulus involved in sensory perception of sound

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

cochlea morphogenesis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

positive regulation by host of viral transcription

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

reflex [inference]

pilomotor reflex

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

response to endogenous stimulus [inference]

response to hormone [inference]

response to thyroid hormone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to thyroid hormone

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of thyroid hormone generation

positive regulation of hormone metabolic process [inference]

positive regulation of thyroid hormone generation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of thyroid hormone generation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of thyroid hormone generation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of thyroid hormone generation [inference]

positive regulation of thyroid hormone generation

regulation of hormone metabolic process [inference]

positive regulation of hormone metabolic process [inference]

positive regulation of thyroid hormone generation

regulation of thyroid hormone generation [inference]

positive regulation of thyroid hormone generation

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of thyroid hormone generation

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of thyroid hormone generation [inference]

positive regulation of thyroid hormone generation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of thyroid hormone generation

positive regulation of hormone metabolic process [inference]

positive regulation of thyroid hormone generation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of thyroid hormone generation

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of hepatocyte proliferation

positive regulation of cell growth

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of thyroid hormone generation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial to mesenchymal transition

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of thyroid hormone generation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of thyroid hormone generation [inference]

positive regulation of thyroid hormone generation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of hepatocyte proliferation

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of hepatocyte proliferation

negative regulation of epithelial cell proliferation

regulation of hepatocyte proliferation [inference]

positive regulation of hepatocyte proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of hepatocyte proliferation

positive regulation of cell growth

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of thyroid hormone generation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial to mesenchymal transition

regulation of biological quality [inference]

regulation of cell shape

regulation of hormone levels [inference]

regulation of hormone metabolic process [inference]

positive regulation of hormone metabolic process [inference]

positive regulation of thyroid hormone generation

regulation of thyroid hormone generation [inference]

positive regulation of thyroid hormone generation

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm
endoplasmic reticulum membrane
plasma membrane
cell-cell junction
cell surface

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

cell body [inference]

neuronal cell body

Displaying **all 3** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IEA	22301074
serine-type peptidase activity
serine-type exopeptidase activity	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

exopeptidase activity [inference]

serine-type exopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

exopeptidase activity [inference]

serine-type exopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Trypsin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity

Displaying **all 6** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site

Ortholog

Displaying entries **1 - 10** of 48 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	3249	HUMAN42588
Mus musculus	15451	MOUSE56206
Rattus norvegicus	29135	RATNO19568
Canis lupus familiaris	484583	CANLF01223
Bos taurus	508148	BOVIN10847
Danio rerio	569259	DANRE09932
Macaca mulatta	707242	MACMU18446
Monodelphis domestica	100015125	MONDO25541
Callithrix jacchus	100401729	CALJA23926
Ailuropoda melanoleuca	100473121	AILME11044

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements