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legumain

Summary

Gene Symbol

LGMN

Organism

Pongo abelii (Sumatran orangutan)

External Links

NCBI Gene: 100173793
PubChem: 100173793

Annotation

Keyword

Disulfide bond
Glycoprotein
Lysosome
Reference proteome
Signal
Thiol protease
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5R5D9	Asparaginyl endopeptidase Protease, cysteine 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
renal system process
proteolysis
vacuolar protein processing	IEA	30032202
antigen processing and presentation of exogenous peptide antigen via MHC class II
receptor catabolic process

GO Hierarchy

biological process

immune system process [inference]

antigen processing and presentation [inference]

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

vacuolar protein processing

proteolysis involved in protein catabolic process

protein maturation [inference]

protein processing [inference]

vacuolar protein processing

catabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

receptor catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

vacuolar protein processing

proteolysis involved in protein catabolic process

protein maturation [inference]

protein processing [inference]

vacuolar protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

receptor catabolic process

protein metabolic process [inference]

proteolysis

protein processing [inference]

vacuolar protein processing

proteolysis involved in protein catabolic process

protein maturation [inference]

protein processing [inference]

vacuolar protein processing

receptor metabolic process [inference]

receptor catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

vacuolar protein processing

proteolysis involved in protein catabolic process

protein maturation [inference]

protein processing [inference]

vacuolar protein processing

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

receptor catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process

multicellular organismal process [inference]

system process [inference]

renal system process

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

regulation of ERBB signaling pathway [inference]

negative regulation of ERBB signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

regulation of ERBB signaling pathway [inference]

negative regulation of ERBB signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

regulation of ERBB signaling pathway [inference]

negative regulation of ERBB signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
lysosome
lysosomal lumen

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying 1 entry
GO Term	Evidence Code	PMID
cysteine-type endopeptidase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

gpi-anchor transamidase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
GPI-anchor transamidase activity
attachment of GPI anchor to protein
hydrolase activity
proteolysis

Displaying 1 entry
InterPro
Peptidase C13, legumain

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	5641	HUMAN20879
Mus musculus	19141	MOUSE08897
Rattus norvegicus	63865	RATNO36583
Bos taurus	281281	BOVIN16895
Danio rerio	406625	DANRE05242
Pan troglodytes	453118	PANTR09405
Canis lupus familiaris	480232	CANLF17707
Ovis aries	678680	SHEEP07985
Macaca mulatta	703734	MACMU41740
Monodelphis domestica	100016534	MONDO08097