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Guidelines

MIRAGE

cholesterol 25-hydroxylase

Summary

Gene Symbol

CH25H

Organism

Taeniopygia guttata (zebra finch)

External Links

NCBI Gene: 100222744
KEGG Gene ID: tgu:100222744
PubChem: 100222744

Annotation

Keyword

Monooxygenase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
H0ZDA2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cholesterol metabolic process	IEA	30032202
sterol biosynthetic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
C-4 methylsterol oxidase activity	IEA	30032202
iron ion binding	IEA	22301074
steroid hydroxylase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

steroid hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

C-4 methylsterol oxidase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

C-4 methylsterol oxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cholesterol 25-hydroxylase

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 10** entries
Gene Ontology
C-4 methylsterol oxidase activity
C-5 sterol desaturase activity
cholesterol biosynthetic process via lathosterol
ergosterol biosynthetic process
iron ion binding
lipid biosynthetic process
oxidoreductase activity
sphingolipid biosynthetic process
sphingolipid delta-4 desaturase activity
sphingosine hydroxylase activity

Displaying 1 entry
InterPro
Fatty acid hydroxylase

KEGG BRITE Database

Orthology

K10223

Name

cholesterol 25-hydroxylase [EC:1.14.99.38]

References

9852097

Rhea

O₂ + cholesterol + AH₂

A + H₂O + 25-hydroxycholesterol

Enzyme

1.14.99.38

PMID

Ortholog

Displaying entries **1 - 10** of 67 in total

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Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9023		HUMAN02093
Mus musculus	12642		MOUSE25396
Rattus norvegicus	309527		RATNO15977
Pan troglodytes	450584		PANTR01109
Danio rerio	494109		DANRE03735
Macaca mulatta	694532		MACMU46413
Equus caballus	100062138		HORSE15939
Ornithorhynchus anatinus	100078582		ORNAN17525
Sus scrofa	100157868		PIGXX08103
Salmo salar	100195833		SALSA100343

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025