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sphingosine kinase 2

Summary

Gene Symbol

SPHK2

Organism

Callithrix jacchus (white-tufted-ear marmoset)

External Links

NCBI Gene: 100387720
KEGG Gene ID: cjc:100387720
PubChem: 100387720

Annotation

Keyword

ATP-binding
Kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
U3EXH5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
sphinganine-1-phosphate biosynthetic process	IEA	30032202
sphingosine biosynthetic process	IEA	30032202
positive regulation of apoptotic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

phospholipid metabolic process [inference]

sphinganine-1-phosphate metabolic process [inference]

sphinganine-1-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

sphinganine-1-phosphate biosynthetic process

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA	30032202
intracellular membrane-bounded organelle	IEA	30032202
cytoplasm	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying 1 entry
GO Term	Evidence Code	PMID
D-erythro-sphingosine kinase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

lipid kinase activity [inference]

D-erythro-sphingosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

D-erythro-sphingosine kinase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sphingosine kinase A

Functional Category

G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
D-erythro-sphingosine kinase activity
kinase activity
phosphorylation
sphingosine biosynthetic process

Displaying **all 3** entries
InterPro
Diacylglycerol kinase, catalytic domain
Inorganic polyphosphate/ATP-NAD kinase, N-terminal
NAD kinase/diacylglycerol kinase-like domain superfamily

KEGG BRITE Database

Orthology

K04718

Name

sphingosine kinase [EC:2.7.1.91]

References

Ortholog

Displaying entries **21 - 30** of 67 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Jaculus jaculus	101608680			JACJA24392
Mustela putorius furo	101672769			MUSPF06934
Heterocephalus glaber	101720879			HETGA20946
Ictidomys tridecemlineatus	101972510			ICTTR05971
Chinchilla lanigera	102007376			CHILA24052
Capra hircus	102184187			CAPHI09354
Astyanax mexicanus	103043132			ASTMX09065
Chlorocebus sabaeus	103234983			CHLSB15990
Carlito syrichta	103250049	1868482_0:0009f1		CARSF24828
Ursus maritimus	103657238			URSMA25483

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Last updated: December 9, 2024