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arachidonate 12-lipoxygenase, 12R type

Summary

Gene Symbol

ALOX12B

Organism

Pongo abelii (Sumatran orangutan)

External Links

NCBI Gene: 100445399
KEGG Gene ID: pon:100445399
PubChem: 100445399

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
arachidonic acid metabolic process	IEA	30032202
linoleic acid metabolic process	IEA	30032202
lipid oxidation	IEA	30032202
hepoxilin biosynthetic process	IEA	30032202
lipoxygenase pathway	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

lipid modification [inference]

lipid oxidation

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

lipid modification [inference]

lipid oxidation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

lipid modification [inference]

lipid oxidation

olefinic compound metabolic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

lipid modification [inference]

lipid oxidation

Displaying 1 entry
GO Term	Evidence Code	PMID
perinuclear region of cytoplasm	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

perinuclear region of cytoplasm

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IEA	22301074
iron ion binding	IEA	22301074
arachidonate 12(S)-lipoxygenase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

arachidonate 12(S)-lipoxygenase activity

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

arachidonate 12(S)-lipoxygenase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Lipoxygenase

Functional Category

P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
metal ion binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
oxidoreductase activity

KEGG BRITE Database

Orthology

K08021

Name

arachidonate 12-lipoxygenase (R-type) [EC:1.13.11.-]

References

12432922

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	242	9606_1:003f8a	HUMAN31610
Mus musculus	11686		MOUSE05465
Rattus norvegicus	287425		RATNO01135
Pan troglodytes	455103	9598_0:0047f9	PANTR14858
Canis lupus familiaris	489486		CANLF15478
Bos taurus	504803		BOVIN12785
Macaca mulatta	721936		MACMU14866
Monodelphis domestica	100013747		MONDO12847
Equus caballus	100062323		HORSE03696
Ornithorhynchus anatinus	100087885		ORNAN32105

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements