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purinergic receptor P2X 3

Summary

Gene Symbol

P2RX3

Organism

Ailuropoda melanoleuca (giant panda)

External Links

NCBI Gene: 100476571
PubChem: 100476571

Annotation

Keyword

ATP-binding
Disulfide bond
Glycoprotein
Ion channel
Receptor
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
D2HK57

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
monoatomic cation transmembrane transport	IEA	22301074
behavioral response to pain
sensory perception of taste
protein homotrimerization
establishment of localization in cell

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

neuromuscular synaptic transmission

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction [inference]

phasic smooth muscle contraction [inference]

peristalsis

urinary tract smooth muscle contraction [inference]

urinary bladder smooth muscle contraction

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of taste

behavior [inference]

behavioral response to pain

response to stimulus [inference]

response to stress [inference]

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to mechanical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

response to chemical [inference]

response to organic substance [inference]

response to carbohydrate

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to ATP

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to ATP

cellular response to ATP

cellular response to organic cyclic compound [inference]

cellular response to ATP

response to organophosphorus [inference]

response to ATP

cellular response to ATP

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to ATP

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

response to oxygen-containing compound [inference]

response to carbohydrate

response to ATP

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

response to salt [inference]

response to ATP

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

monoatomic cation transmembrane transport

calcium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

neuromuscular synaptic transmission

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of biological quality [inference]

regulation of synaptic plasticity

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
hippocampal mossy fiber to CA3 synapse
axon

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

organelle inner membrane [inference]

nuclear inner membrane

nuclear membrane [inference]

nuclear inner membrane

cell junction [inference]

synapse [inference]

Schaffer collateral - CA1 synapse

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

postsynapse

Displaying **all 3** entries
GO Term	Evidence Code	PMID
purinergic nucleotide receptor activity	IEA	22301074
extracellularly ATP-gated monoatomic cation channel activity	IEA	22301074 30032202
ATP binding	IEA	22301074

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ATP-gated ion channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

nucleotide receptor activity [inference]

purinergic nucleotide receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

p2X purinoceptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
calcium ion transmembrane transport
excitatory postsynaptic potential
extracellularly ATP-gated monoatomic cation channel activity
monoatomic ion channel activity
monoatomic ion transport
response to ATP

Displaying **all 2** entries
InterPro
P2X purinoreceptor extracellular domain superfamily
P2X purinoreceptor

Ortholog

Displaying entries **71 - 80** of **103** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Podarcis muralis	114601495		PODMU07162
Salmo trutta	115191875		SALTR31509
Salmo trutta	115202032		SALTR31509
Suricata suricatta	115306485	37032_0:0030ce
Lynx canadensis	115525326	61383_0:002dda
Gadus morhua	115540974		GADMO42285
Sparus aurata	115588055		SPAAU55435
Mustela erminea	116599246	36723_0:002985
Phoca vitulina	116638779	9720_0:0021da
Chelonoidis abingdonii	116827987		CHEAB28613