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ring finger protein 43

Summary

Gene Symbol

rnf43

Organism

Xenopus tropicalis (tropical clawed frog)

External Links

NCBI Gene

100491274

PubChem

100491274

Alliance of Genome Resources

Xenbase:XB-GENE-952685

Annotation

Keyword

Cell membrane
Developmental protein
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Nucleus
Reference proteome
Signal
Transferase
Transmembrane helix
Ubl conjugation pathway
Wnt signaling pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
P0DPR2	RING finger protein 43 RING-type E3 ubiquitin transferase RNF43

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
ubiquitin-dependent protein catabolic process	IBA
Wnt signaling pathway	IEA
protein ubiquitination	IEA
Wnt receptor catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

catabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process [inference]

Wnt receptor catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

receptor catabolic process [inference]

Wnt receptor catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process [inference]

Wnt receptor catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

receptor catabolic process [inference]

Wnt receptor catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

receptor metabolic process [inference]

receptor catabolic process [inference]

Wnt receptor catabolic process

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

receptor catabolic process [inference]

Wnt receptor catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process [inference]

Wnt receptor catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
nuclear envelope	IEA
endoplasmic reticulum	IEA
endoplasmic reticulum membrane	IEA
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
frizzled binding	IBA
zinc ion binding	IEA
transferase activity	IEA
metal ion binding
ubiquitin protein ligase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

frizzled binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

e3 ubiquitin-protein ligase rnf43

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
Wnt receptor catabolic process
ligase activity
metal ion binding
protein ubiquitination
transferase activity

Displaying **all 3** entries
InterPro
ZNRF-3, ectodomain
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

GlyCosmos Portal v4.5.0

Last updated: April 6, 2026

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