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phospholipid phosphatase 1

Summary

Gene Symbol

PLPP1

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 100515451
KEGG Gene ID: ssc:100515451
PubChem: 100515451

Annotation

Keyword

Cell membrane
Direct protein sequencing
Glycoprotein
Hydrolase
Lipid metabolism
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 6** entries
UniProt	Protein Name
A0A4X1SM48	Lipid phosphate phosphohydrolase 1 PAP2-alpha Phosphatidate phosphohydrolase type 2a Phosphatidic acid phosphatase 2a
A0A4X1SM51	Lipid phosphate phosphohydrolase 1 PAP2-alpha Phosphatidate phosphohydrolase type 2a Phosphatidic acid phosphatase 2a
A0A4X1SL15	Lipid phosphate phosphohydrolase 1 PAP2-alpha Phosphatidate phosphohydrolase type 2a Phosphatidic acid phosphatase 2a
P60588	Lipid phosphate phosphohydrolase 1 PAP2-alpha Phosphatidate phosphohydrolase type 2a Phosphatidic acid phosphatase 2a
A0A8D0ILX9	Lipid phosphate phosphohydrolase 1 PAP2-alpha Phosphatidate phosphohydrolase type 2a Phosphatidic acid phosphatase 2a
A0A286ZXH9	Lipid phosphate phosphohydrolase 1 PAP2-alpha Phosphatidate phosphohydrolase type 2a Phosphatidic acid phosphatase 2a

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
phospholipid metabolic process	IEA	30032202
sphingosine metabolic process
ceramide metabolic process
signal transduction	IEA	30032202
phospholipid catabolic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

phospholipid catabolic process

dephosphorylation [inference]

phospholipid dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process

phospholipid catabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

phospholipid catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process

phospholipid catabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

phospholipid catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process

phospholipid catabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

phospholipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

cellular process [inference]

signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

phospholipid catabolic process

dephosphorylation [inference]

phospholipid dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process

phospholipid catabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

phospholipid catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane
caveola
membrane
apical plasma membrane
membrane raft

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft

plasma membrane raft [inference]

caveola

Displaying **all 5** entries
GO Term	Evidence Code	PMID
diacylglycerol diphosphate phosphatase activity
phosphatidate phosphatase activity	IEA	30032202
sphingosine-1-phosphate phosphatase activity
lysophosphatidic acid phosphatase activity
ceramide-1-phosphate phosphatase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

lipid phosphatase activity [inference]

lysophosphatidic acid phosphatase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

diacylglycerol diphosphate phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

phosphatidate phosphatase

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
phospholipid dephosphorylation
phospholipid metabolic process

Displaying **all 3** entries
InterPro
Phosphatidate (PA) phosphatase-related
Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
Phosphatidic acid phosphatase type 2/haloperoxidase

KEGG BRITE Database

Orthology

K01080

Name

phosphatidate phosphatase [EC:3.1.3.4]

References

Rhea

RHEA:33155

H₂O + a 1-acyl-sn-glycero-3-phosphate

phosphate + a 1-acyl-sn-glycerol

Enzyme

3.1.3.106

PMID

RHEA:27429

H₂O + a 1,2-diacyl-sn-glycero-3-phosphate

a 1,2-diacyl-sn-glycerol + phosphate

Enzyme

3.1.3.4

PMID

RHEA:36239

H₂O + 1-O-alkyl-2-acyl-sn-glycero-3-phosphate

phosphate + 1-O-alkyl-2-acyl-sn-glycerol

Enzyme

3.1.3.4

RHEA:27449

H₂O + a 1,2-diacyl-sn-glycerol 3-diphosphate

H⁺ + phosphate + a 1,2-diacyl-sn-glycero-3-phosphate

Enzyme

3.6.1.75

PMID

Ortholog

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	8611	HUMAN79177
Mus musculus	19012	MOUSE11548
Rattus norvegicus	64369	RATNO24252
Pan troglodytes	461869	PANTR35551
Danio rerio	569053	DANRE00097
Canis lupus familiaris	607962	CANLF06702
Bos taurus	617172	BOVIN15927
Macaca mulatta	706539	MACMU39688
Oryctolagus cuniculus	100008821	RABIT01982
Monodelphis domestica	100031858	MONDO16861

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Acknowledgements