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ATP binding cassette subfamily B member 6 (LAN blood group)

Summary

Gene Symbol

ABCB6

Organism

Homo sapiens (human)

External Links

NCBI Gene

10058

PubChem

10058

Alliance of Genome Resources

HGNC:47

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Disease variant
Disulfide bond
Dyskeratosis congenita
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Lysosome
Microphthalmia
Mitochondrion outer membrane
Reference proteome
Secreted
Translocase
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NP58	ABC-type heme transporter ABCB6 Mitochondrial ABC transporter 3 P-glycoprotein-related protein Ubiquitously-expressed mammalian ABC half transporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 17** of 17 in total

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GO Term	Evidence Code	PMID
cellular detoxification of cadmium ion	IDA	31053883
melanosome assembly	IDA	29940187

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme metabolic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

pigment metabolic process [inference]

heme metabolic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

pigment biosynthetic process [inference]

heme biosynthetic process [inference]

heme B biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

tetrapyrrole metabolic process

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme metabolic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

tetrapyrrole metabolic process

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme metabolic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

tetrapyrrole metabolic process

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme metabolic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme metabolic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

tetrapyrrole metabolic process

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme metabolic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

tetrapyrrole metabolic process

porphyrin-containing compound metabolic process

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme metabolic process

heme biosynthetic process [inference]

heme B biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process

heme biosynthetic process [inference]

heme B biosynthetic process

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

heme transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

heme transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

pigment granule organization [inference]

melanosome organization [inference]

melanosome assembly

organelle assembly [inference]

melanosome assembly

cellular component assembly [inference]

organelle assembly [inference]

melanosome assembly

cellular detoxification [inference]

cellular detoxification of metal ion [inference]

cellular detoxification of cadmium ion

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

copper ion homeostasis [inference]

intracellular copper ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

copper ion homeostasis [inference]

intracellular copper ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport [inference]

iron ion transmembrane transport [inference]

heme transmembrane transport

iron coordination entity transport [inference]

heme transport

heme transmembrane transport

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

heme transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

heme transmembrane transport

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

heme transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

heme transmembrane transport

organic substance transport [inference]

heme transport

heme transmembrane transport

nitrogen compound transport [inference]

heme transport

heme transmembrane transport

detoxification [inference]

detoxification of inorganic compound [inference]

detoxification of cadmium ion [inference]

cellular detoxification of cadmium ion

cellular detoxification of metal ion [inference]

cellular detoxification of cadmium ion

cellular detoxification [inference]

cellular detoxification of metal ion [inference]

cellular detoxification of cadmium ion

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IEA
nucleoplasm	IDA
mitochondrion	IDA	10837493 18279659 22655043
mitochondrion	IMP	23792964
mitochondrion	HTP	34800366

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

ATP-binding cassette (ABC) transporter complex

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

late endosome membrane [inference]

multivesicular body membrane

endolysosome membrane

pigment granule membrane [inference]

melanosome membrane

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane

lytic vacuole membrane [inference]

lysosomal membrane

endolysosome membrane

endosome membrane [inference]

early endosome membrane

late endosome membrane [inference]

multivesicular body membrane

endolysosome membrane

organelle outer membrane [inference]

mitochondrial outer membrane

pigment granule membrane [inference]

melanosome membrane

envelope [inference]

organelle envelope [inference]

mitochondrial envelope

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
ATP binding	IDA	10837493 27507172
ABC-type heme transporter activity	TAS
ABC-type heme transporter activity	IMP	17006453
ABC-type heme transporter activity	IBA
efflux transmembrane transporter activity	IDA	17661442

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

heme transmembrane transporter activity [inference]

ABC-type heme transporter activity

efflux transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity

ABC-type heme transporter activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

tetrapyrrole binding

heme binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity

ABC-type heme transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATP-binding cassette sub-family B member

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ABC-type transporter activity
ATP binding
intracellular iron ion homeostasis
nucleotide binding

Displaying **all 7** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase
Type 1 protein exporter

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060304	dyschromatosis universalis hereditaria	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10058	Xenbase:XB-GENE-1001119
Mus musculus	74104		MOUSE30799
Rattus norvegicus	140669		RATNO42977
Danio rerio	564067		DANRE17175
Macaca mulatta	702263		MACMU06513
Macaca mulatta	704599		MACMU06513
Xenopus tropicalis	780100	Xenbase:XB-GENE-1001119
Bos taurus	783257		BOVIN24781
Danio rerio	100004801		DANRE45342
Monodelphis domestica	100010684		MONDO32722

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Acknowledgements