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FIC domain protein adenylyltransferase

Summary

Gene Symbol

FICD

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 100621588
PubChem: 100621588

Annotation

Keyword

ATP-binding
Membrane
Nucleotidyltransferase
Reference proteome
TPR repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A480X7L8	AMPylator FICD FIC domain-containing protein
A0A8D0M7F3	AMPylator FICD FIC domain-containing protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein adenylylation
response to endoplasmic reticulum stress
regulation of IRE1-mediated unfolded protein response

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

macromolecule modification [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane
membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IEA	22301074
ATP binding
Hsp70 protein binding
protein homodimerization activity
AMPylase activity

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

adenylyltransferase activity [inference]

AMPylase activity

binding [inference]

protein binding

heat shock protein binding [inference]

Hsp70 protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

protein-folding chaperone binding [inference]

Hsp70 protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

adenosine monophosphate-protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
AMPylase activity
ATP binding
nucleotide binding

Displaying **all 4** entries
InterPro
Fido domain-containing protein
Fido domain
Fido-like domain superfamily
Tetratricopeptide-like helical domain superfamily

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025

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