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solute carrier family 19 member 1

Summary

Gene Symbol

Slc19a1

Organism

Cricetulus griseus (Chinese hamster)

External Links

NCBI Gene: 100689407
PubChem: 100689407

Annotation

Keyword

Acetylation
Antiport
Cell membrane
Folate-binding
Glycoprotein
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P42557	Methotrexate uptake protein Plasma membrane folate antiporter SLC19A1 Reduced folate carrier 1 Solute carrier family 19 member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
methotrexate transport	IEA	22301074
folate transmembrane transport	IEA	30032202
cyclic-GMP-AMP transmembrane import across plasma membrane
positive regulation of cGAS/STING signaling pathway
folate import across plasma membrane

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

vitamin transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

import across plasma membrane [inference]

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

localization [inference]

establishment of localization [inference]

transport [inference]

vitamin transport [inference]

folic acid transport [inference]

folate transmembrane transport

folate import across plasma membrane

vitamin transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

transmembrane transport [inference]

vitamin transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

import across plasma membrane [inference]

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport [inference]

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

cyclic-GMP-AMP transmembrane import across plasma membrane

organophosphate ester transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport [inference]

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

modified amino acid transport [inference]

folic acid transport [inference]

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

carbohydrate derivative transport [inference]

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

amide transport [inference]

folic acid transport [inference]

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

modified amino acid transport [inference]

folic acid transport [inference]

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

import into cell [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IEA	22301074 30032202
basolateral plasma membrane	IEA	30032202
apical plasma membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
folic acid binding	IEA	30032202
folate:monoatomic anion antiporter activity	IEA	22301074 30032202
antiporter activity
methotrexate transmembrane transporter activity	IEA	22301074
2',3'-cyclic GMP-AMP binding