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Guidelines

MIRAGE

cathepsin D

Summary

Gene Symbol

Ctsd

Organism

Cavia porcellus (domestic guinea pig)

External Links

NCBI Gene: 100735735
PubChem: 100735735

Annotation

Keyword

Aspartyl protease
Disulfide bond
Lysosome
Reference proteome
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
H0VCH6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
autophagosome assembly
proteolysis	IEA	22301074 30032202
insulin receptor recycling
lipoprotein catabolic process
positive regulation of apoptotic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process [inference]

lipoprotein metabolic process [inference]

lipoprotein catabolic process

insulin metabolic process [inference]

insulin catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process [inference]

lipoprotein metabolic process [inference]

lipoprotein catabolic process

insulin metabolic process [inference]

insulin catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process [inference]

lipoprotein metabolic process [inference]

lipoprotein catabolic process

insulin metabolic process [inference]

insulin catabolic process

receptor metabolic process [inference]

receptor recycling [inference]

insulin receptor recycling

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process [inference]

lipoprotein metabolic process [inference]

lipoprotein catabolic process

insulin metabolic process [inference]

insulin catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular space
lysosome	IEA	22301074
lysosomal membrane
endosome membrane
endosome lumen

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

membrane microdomain [inference]

membrane raft

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endosome lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying 1 entry
GO Term	Evidence Code	PMID
aspartic-type endopeptidase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

aspartic-type endopeptidase activity

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

aspartic-type endopeptidase activity

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

pregnancy-associated glycoprotein

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
aspartic-type endopeptidase activity
hydrolase activity
proteolysis

Displaying **all 4** entries
InterPro
Aspartic peptidase A1 family
Aspartic peptidase domain superfamily
Aspartic peptidase, active site
Peptidase family A1 domain

Ortholog

Displaying entries **51 - 60** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Cyprinus carpio carpio	109105685		CYPCA67158
Crocodylus porosus	109321190		CROPO08646
Vulpes vulpes	112924136		VULVU17678
Athene cunicularia	113481131		ATHCN18422
Electrophorus electricus	113592030		ELEEL47858
Bos indicus x Bos taurus	113885866		BOBOX00890
Vombatus ursinus	114047772		VOMUR29436
Podarcis muralis	114599332		PODMU08428
Echeneis naucrates	115040724		ECHNA24441
Salmo trutta	115166723		SALTR81309

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025