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HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1

Summary

Gene Symbol

HUWE1

Organism

Homo sapiens (human)

External Links

NCBI Gene

10075

PubChem

10075

Alliance of Genome Resources

HGNC:30892

JoGo

HUWE1

TogoVar

HUWE1

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Biological rhythms
Chromosomal rearrangement
Cytoplasm
DNA repair
DNA-binding
Differentiation
Disease variant
Intellectual disability
Methylation
Mitochondrion
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transferase
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q7Z6Z7	ARF-binding protein 1 HECT, UBA and WWE domain-containing protein 1 HECT-type E3 ubiquitin transferase HUWE1 Homologous to E6AP carboxyl terminus homologous protein 9 Large structure of UREB1 Mcl-1 ubiquitin ligase E3 Upstream regulatory element-binding protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
protein polyubiquitination	IDA	15989957
base-excision repair	IMP	19713937
base-excision repair	IBA
chromatin remodeling	IEA
ubiquitin-dependent protein catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

protein K48-linked ubiquitination

protein monoubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

protein K48-linked ubiquitination

protein monoubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

protein K48-linked ubiquitination

protein monoubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

protein K48-linked ubiquitination

protein monoubiquitination

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

protein K48-linked ubiquitination

protein monoubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

cellular developmental process [inference]

cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

Golgi organization

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

membrane organization [inference]

membrane fusion

developmental process [inference]

cellular developmental process [inference]

cell differentiation

rhythmic process [inference]

circadian rhythm [inference]

circadian regulation of gene expression

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of mitophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of mitophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signal transduction [inference]

negative regulation of peroxisome proliferator activated receptor signaling pathway

regulation of peroxisome proliferator activated receptor signaling pathway [inference]

negative regulation of peroxisome proliferator activated receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of peroxisome proliferator activated receptor signaling pathway

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein targeting [inference]

regulation of protein targeting to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

regulation of establishment of protein localization to mitochondrion [inference]

regulation of protein targeting to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of peroxisome proliferator activated receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peroxisome proliferator activated receptor signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of peroxisome proliferator activated receptor signaling pathway

negative regulation of developmental process [inference]

negative regulation of mitochondrial fusion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signal transduction [inference]

negative regulation of peroxisome proliferator activated receptor signaling pathway

regulation of peroxisome proliferator activated receptor signaling pathway [inference]

negative regulation of peroxisome proliferator activated receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of peroxisome proliferator activated receptor signaling pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of mitochondrial fusion [inference]

negative regulation of mitochondrial fusion

negative regulation of developmental process [inference]

negative regulation of mitochondrial fusion

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signal transduction [inference]

negative regulation of peroxisome proliferator activated receptor signaling pathway

regulation of peroxisome proliferator activated receptor signaling pathway [inference]

negative regulation of peroxisome proliferator activated receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peroxisome proliferator activated receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of mitophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peroxisome proliferator activated receptor signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of mitochondrion organization [inference]

regulation of mitochondrial fusion [inference]

negative regulation of mitochondrial fusion

positive regulation of mitochondrion organization [inference]

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein targeting [inference]

regulation of protein targeting to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

regulation of establishment of protein localization to mitochondrion [inference]

regulation of protein targeting to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of establishment of protein localization to mitochondrion [inference]

positive regulation of protein targeting to mitochondrion

regulation of cellular response to stress [inference]

regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [inference]

positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IBA
extracellular region	TAS
nucleus	ISS
nucleus	IBA
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

ficolin-1-rich granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
DNA binding	ISS
RNA binding	HDA	22658674
ubiquitin-protein transferase activity	IDA	15989957 19713937
protein binding	IPI	15989956 19713937 20023629 20534529 21507240 21522127 25277244 26496610 28169274 30217973 32814053 33961781 35776542 36631436
ubiquitin-ubiquitin ligase activity	IDA	27746020

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

histone modifying activity [inference]

histone ubiquitin ligase activity

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

E3 ubiquitin-protein ligase huwe1

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
DNA repair
Golgi organization
base-excision repair
protein polyubiquitination
protein ubiquitination
transferase activity

Displaying **all 10** entries
InterPro
E3 ubiquitin ligase, domain of unknown function DUF908
E3 ubiquitin ligase, domain of unknown function DUF913
HECT domain
HECT, E3 ligase catalytic domain
HUWE1, UBA domain
HUWE1/REV1, ubiquitin-binding motif
UBA-like superfamily
Ubiquitin-associated domain
WWE domain superfamily
WWE domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060811	syndromic X-linked intellectual disability Turner type	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements