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uronyl 2-sulfotransferase

Summary

Gene Symbol

Aliases

2OST

Organism

Homo sapiens (human)

External Links

NCBI Gene

10090

GGDB ID

gg039

HGNC

17223

mRNA

NM_005715

map

6q25.1

Protein

NP_005706

OMIM

610752

KEGG Gene ID

hsa:10090

PubChem

10090

Alliance of Genome Resources

HGNC:17223

Annotation

Keyword

Glycoprotein
Golgi apparatus
Proteomics identification
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y2C2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein sulfation
establishment of cell polarity	IEA
dermatan sulfate biosynthetic process	TAS
dermatan sulfate biosynthetic process	IDA	10187838
regulation of axonogenesis	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein sulfation

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfation [inference]

protein sulfation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein sulfation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein sulfation

macromolecule modification [inference]

protein modification process [inference]

protein sulfation

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

amino disaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein sulfation

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

cellular process [inference]

establishment or maintenance of cell polarity [inference]

establishment of cell polarity

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfation [inference]

protein sulfation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis

regulation of cellular process [inference]

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
membrane	TAS	10187838

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
sulfotransferase activity	TAS
sulfotransferase activity	IBA
chondroitin 2-O-sulfotransferase activity	IDA	10187838 17227754
3'-phosphoadenosine 5'-phosphosulfate binding	IDA	17227754
[dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity	IDA	10187838

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity

chondroitin sulfotransferase activity [inference]

chondroitin 2-O-sulfotransferase activity

[dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

ion binding [inference]

anion binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

sulfur compound binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

2-O-sulfotransferase

Functional Category

G: Carbohydrate transport and metabolism
H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying 1 entry
Gene Ontology
sulfotransferase activity

Displaying **all 3** entries
InterPro
Heparan sulphate 2-O-sulfotransferase
P-loop containing nucleoside triphosphate hydrolase
Sulfotransferase

GlycoGene Database (GGDB)

GGDB ID

gg039

Gene Symbol

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Mus musculus	NP_796361	NM_177387
Rattus norvegicus	XP_341728	XM_341729

KEGG BRITE Database

Orthology

K03193

Name

dermatan/chondrotin sulfate uronyl 2-O-sulfotransferase UST [EC:2.8.2.-]

References

10187838

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1094	attention deficit hyperactivity disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	10090	Xenbase:XB-GENE-6486769
Drosophila melanogaster	40104	FB:FBgn0003089
Mus musculus	338362	ZFIN:ZDB-GENE-041001-163	MOUSE01748
Rattus norvegicus	361450	ZFIN:ZDB-GENE-041001-163	RATNO16446
Canis lupus familiaris	476238		CANLF00192
Bos taurus	535975		BOVIN35953
Danio rerio	557218	ZFIN:ZDB-GENE-041001-163	DANRE19472
Macaca mulatta	697355		MACMU35178
Pan troglodytes	748624		PANTR39267
Monodelphis domestica	100026835		MONDO10646

GlyTouCan

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UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements