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angiotensin I converting enzyme

Summary

Gene Symbol

Organism

Pan paniscus (pygmy chimpanzee)

External Links

NCBI Gene: 100980711
KEGG Gene ID: pps:100980711
PubChem: 100980711

Annotation

Keyword

Carboxypeptidase
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Signal
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A2R8ZYP1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
proteolysis	IEA	22301074 30032202
positive regulation of systemic arterial blood pressure	IEA	30032202
regulation of systemic arterial blood pressure by renin-angiotensin	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

multicellular organismal process [inference]

system process [inference]

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin

biological regulation [inference]

regulation of biological quality [inference]

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin

positive regulation of blood pressure [inference]

positive regulation of systemic arterial blood pressure

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
peptidyl-dipeptidase activity	IEA	22301074 30032202
metal ion binding
metallopeptidase activity	IEA	22301074 30032202
carboxypeptidase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity

exopeptidase activity [inference]

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity

exopeptidase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

angiotensin-converting enzyme isoform 1 precursor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

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Gene Ontology
amyloid-beta metabolic process
angiotensin-activated signaling pathway
arachidonic acid secretion
bradykinin catabolic process
bradykinin receptor binding
carboxypeptidase activity
cell proliferation in bone marrow
chloride ion binding
exopeptidase activity
heart contraction

Displaying 1 entry
InterPro
Peptidase M2, peptidyl-dipeptidase A

KEGG BRITE Database

Orthology

K01283

Name

peptidyl-dipeptidase A [EC:3.4.15.1]

References

Ortholog

Displaying entries **1 - 10** of 24 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	1636	9606_1:004085
Pan troglodytes	449567	9598_0:0047c7	PANTR15146
Equus caballus	100064801		HORSE04640
Pongo abelii	100453403	9601_0:004392
Nomascus leucogenys	100592115		NOMLE16246
Saimiri boliviensis boliviensis	101052117		SAIBB36499
Gorilla gorilla gorilla	101145787	9595_0:001bfc
Heterocephalus glaber	101701835		HETGA12181
Chinchilla lanigera	102027972		CHILA17794
Macaca fascicularis	102128376		MACFA14505

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements