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MIRAGE

NUBP iron-sulfur cluster assembly factor 2, cytosolic

Summary

Gene Symbol

NUBP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

10101

PubChem

10101

Alliance of Genome Resources

HGNC:8042

JoGo

NUBP2

TogoVar

NUBP2

Annotation

Keyword

4Fe-4S
ATP-binding
Acetylation
Cilium
Cilium biogenesis/degradation
Cytoskeleton
Direct protein sequencing
Nucleus
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7Z6P0
Q9Y5Y2	Nucleotide-binding protein 2
H3BQR2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
iron-sulfur cluster assembly	IBA
cell projection organization	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

iron-sulfur cluster assembly

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

iron-sulfur cluster assembly

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

metallo-sulfur cluster assembly [inference]

iron-sulfur cluster assembly

cell projection organization

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
nucleus
nucleoplasm	IDA
centriole	IEA
cytosol	IDA
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

microtubule organizing center [inference]

centrosome [inference]

spindle pole centrosome

cytosol

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

centriole

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

centriole

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
nucleotide binding	TAS	10486206
protein binding	IPI	18573874 25416956 32296183 33961781
ATP binding	IEA
metal ion binding	IEA
iron-sulfur cluster binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

metal cluster binding [inference]

iron-sulfur cluster binding

4 iron, 4 sulfur cluster binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular carrier activity [inference]

metallochaperone activity [inference]

ATP-dependent FeS chaperone activity

ATP-dependent activity [inference]

ATP-dependent FeS chaperone activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytosolic Fe-S cluster assembly factor

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
4 iron, 4 sulfur cluster binding
ATP binding
ATP-dependent FeS chaperone activity
iron-sulfur cluster assembly
iron-sulfur cluster binding
metal ion binding
nucleotide binding

Displaying **all 5** entries
InterPro
Cytosolic Fe-S cluster assembly factor NUBP1/Nbp35
Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
Iron-sulfur cluster carrier protein-like, conserved site
Mrp/NBP35 ATP-binding protein
P-loop containing nucleoside triphosphate hydrolase

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025